Neurotransmitter 3D Animation
on Tuesday, December 21, 2010




Neurotransmitters are endogenous chemicals which transmit signals from a neuron to a target cell across a synapse. Neurotransmitters are packaged into synaptic vesicles clustered beneath the membrane on the presynaptic side of a synapse, and are released into the synaptic cleft, where they bind to receptors in the membrane on the postsynaptic side of the synapse. Release of neurotransmitters usually follows arrival of an action potential at the synapse, but may also follow graded electrical potentials. Low level "baseline" release also occurs without electrical stimulation. Neurotransmitters are synthesized from plentiful and simple precursors, such as amino acids, which are readily available from the diet and which require only a small number of biosynthetic steps to convert. The chemical identity of neurotransmitters is often difficult to determine experimentally. For example, it is easy using an electron microscope to recognize vesicles on the presynaptic side of a synapse, but it may not be easy to determine directly what chemical is packed into them. The difficulties led to many historical controversies over whether a given chemical was or was not clearly established as a transmitter. In an effort to give some structure to the arguments, neurochemists worked out a set of experimentally tractable rules. According to the prevailing beliefs of the 1960s, a chemical can be classified as a neurotransmitter if it meets the following conditions: * There are precursors and/or synthesis enzymes located in the presynaptic side of the synapse. * The chemical is present in the presynaptic element. * It is available in sufficient quantity in the presynaptic neuron to affect the postsynaptic neuron; * There are postsynaptic receptors and the chemical is able to bind to them. * A biochemical mechanism for inactivation is present. There are many different ways to classify neurotransmitters. Dividing them into amino acids, peptides, and monoamines is sufficient for some classification purposes. Major neurotransmitters: * Amino acids: glutamate, aspartate, D-serine, γ-aminobutyric acid (GABA), glycine * Monoamines and other biogenic amines: dopamine (DA), norepinephrine (noradrenaline; NE, NA), epinephrine (adrenaline), histamine, serotonin (SE, 5-HT), melatonin * Others: acetylcholine (ACh), adenosine, anandamide, nitric oxide, etc. In addition, over 50 neuroactive peptides have been found, and new ones are discovered regularly. Many of these are "co-released" along with a small-molecule transmitter, but in some cases a peptide is the primary transmitter at a synapse. β-endorphin is a relatively well known example of a peptide neurotransmitter; it engages in highly specific interactions with opioid receptors in the central nervous system. Single ions, such as synaptically released zinc, are also considered neurotransmitters by some[by whom?], as are some gaseous molecules such as nitric oxide (NO) and carbon monoxide (CO). These are not classical neurotransmitters by the strictest definition, however, because although they have all been shown experimentally to be released by presynaptic terminals in an activity-dependent way, they are not packaged into vesicles. By far the most prevalent transmitter is glutamate, which is excitatory at well over 90% of the synapses in the human brain. The next most prevalent is GABA, which is inhibitory at more than 90% of the synapses that do not use glutamate. Even though other transmitters are used in far fewer synapses, they may be very important functionally—the great majority of psychoactive drugs exert their effects by altering the actions of some neurotransmitter systems, often acting through transmitters other than glutamate or GABA. Addictive drugs such as cocaine and amphetamine exert their effects primarily on the dop

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A very funny video showing the other non-bright side of being a doctor

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A video showing the procedure of Tubular Diskectomy of a herniated disk. Uploaded on MedicalVideos.us.Discussing the management of Sciatica.

Basic well-male examination of the genitals and digital rectal exam.

A 3D video clip showing anatomy and physiology of the heart

32 year old Dede Kosawa, also known as 'Tree Man', is one of the world's most extraordinary people. He lives in a remote village in Indonesia with his two children, trying to care for them. Dede, a former fisherman, has an incredible skin condition: he has root like structures growing out of his body - branches that can grow up to 5cm a year and which protrude from his hands and feet, and welts covering his whole body.
He is known locally as ‘Tree Man’ and his condition has baffled local doctors for 20 years. In an attempt to earn a living to support his family, he is part of a circus troupe, displaying his 'Tree Man' limbs along with others afflicted with skin deformities in ‘freak’ shows.
Dr Anthony Gaspari, a world expert in skin conditions from the University of Maryland travels to Indonesia to attempt to diagnose 'Tree Man' Dede’s mysterious condition. He takes skin samples for biopsies back in the USA. What will he discover?
We go on an intimate journey with the extraordinary 'Tree Man' Dede, as he tries to eek out a living in a circus troupe to support his family, and as he is given medical help by Dr Gaspari. The identification and possible cure of his condition, could change his whole life.
Half way across the world, in Romania, farmer Ion Toader is discovered to have a similar extraordinary ‘Tree Man’ condition, with growths all over his hands. He has not been able to drive a tractor for five years. A Romanian surgeon offers to give him an operation to remove his growths.
Will it be successful, and how will it change Ion’s life?

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Revision knee replacement is peformed by Dr.Venkatachalam for lack of mobility. Infection. aseptic loosening are frequent causes requiring a revision. Madras Joint replacement center performs primary and revision knee replacements in a super specialty hospital in Chennai, India. Dr.Venkatachalam, the chief orthopedic surgeon is UK board certified.

Learn how to do a self exam for skin cancer

A video discussing the treatment of Acne with LASER

a video discussing the tattoo removal using LASRER

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دكتور مصطفى ياقوت محاضرة القدم السكرى A lecture presented by Dr. Mostafa Yakoot to the Annual Congress of the Vascular Surgery, Alexandria 10/2009. Based on the original article published in JWC by: Yakoot M, Abdelatif M, Etman M.

After 11 years of my work on my new migraine surgery, I start to do migraine surgery in all 4 principal places - places # 1 (STA) both sides, and places # 3 - Occipital artery also from both sides. You can see my first patients; he had bifrontal migraine headaches and daily chronic headaches in occipital area and the top of the head. On 30 September I sutured the occipital artery from both sides, and on 2 October I sutured STA in places # 1 from both sides. www.alisultaneh.8m.com

Migraine patients and who have any kinds of vascular headaches as (tension, cluster, travel, computer, headaches) can stop the headache within only one minute if he does Dr. Sultaneh pressure points procedure in the correct way.
If migraine headache in the front he must close the artery in place # 1 as you can see. If the headaches in the back of the head he must close the artery in places # 3. When the artery is closed all the headache will stop. After this you have to see my video (How to do migraine devices): www.alisultaneh.8m.com or www.migrainesurgery.4t.com

Discectomy back surgery for removal of a disc by LASER

Simple surgery under a local anesthesia can help cluster headaches patients:
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simple surgery can make basilar migraine patients free of his migraine headache and all accompanied symptoms.
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