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Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. Consequently, the peripheral blood cell profile shows an increased number of granulocytes and their immature precursors, including occasional blast cells.
CML is one of the few cancers known to be caused by a single, specific genetic mutation. More than 90% of cases result from a cytogenetic aberration known as the Philadelphia chromosome (see Pathophysiology).
CML progresses through 3 phases: chronic, accelerated, and blast. In the chronic phase of disease, mature cells proliferate; in the accelerated phase, additional cytogenetic abnormalities occur; in the blast phase, immature cells rapidly proliferate.[1] Approximately 85% of patients are diagnosed in the chronic phase and then progress to the accelerated and blast phases after 3-5 years. The diagnosis of CML is based on the histopathologic findings in the peripheral blood and the Philadelphia chromosome in bone marrow cells (see Workup).
CML accounts for 20% of all leukemias affecting adults. It typically affects middle-aged individuals. Uncommonly, the disease occurs in younger individuals. Younger patients may present with a more aggressive form of CML, such as in accelerated phase or blast crisis. Uncommonly, CML may appear as a disease of new onset in elderly individuals.
The goals of treatment are to achieve hematologic, cytogenetic, and molecular remission. Although a variety of medications have been used in CML, including myelosuppressive agents and interferon alfa, the tyrosine kinase inhibitor imatinib mesylate is currently the agent of choice, and other drugs in this category are playing increasingly important roles. However, allogeneic bone marrow transplantation is currently the only proven cure for CML.
http://www.landging.com/skeletal-system-animation-aci-surgery.html
Designed for medical research organization, this skeletal system animation demonstrates the new concept of ACI (autologous chondrocyte implantation) surgery procedure.
http://www.landging.com/plane-animation.html
420 seconds 3d plane animation, designed for Expo 2010 Shanghai Aviation Pavilion.
http://www.landging.com/accident-animation-slip-and-fall.html
This accident animation demonstrates injuries caused by slip and fall.
http://www.landging.com/animated-city.html
420 seconds 3d animation which is developed for Expo 2010 Shanghai Aviation Pavilion and demonstrates an animated city.
http://www.landging.com/expo2010_case_2.html
Airplane perspective animation, 3d aviation animation, developed for Expo 2010 Shanghai Aviation Pavilion.
http://www.landging.com/underbalanced-drilling.html
This Underbalanced Drilling Animation demonstrates new oil drilling technology.
http://www.landging.com/well-test-animation.html
This well test animation demonstrates new oil drilling technology.
http://www.landging.com/through-tubing.html
This through-tubing perforation animation demonstrates new oil drilling technology.
http://www.landging.com/wireline-logging.html
This wireline logging animation demonstrates new oil drilling technology.
http://www.landging.com/annulus_pressure_responsive.html
This annulus pressure responsive (APR) animation demonstrates new oil drilling technology.
http://www.landging.com/accident-animation-workers-compensation-lifting-box.html
This lifting box accident animation demonstrates the injury covered by workers compensation program.
http://www.landging.com/accident-animation-workers-compensation-falling-stuff.html
This falling stuff accident animation demonstrates the injury covered by workers compensation program.