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Aplastic anemia is a hematopoietic disorder caused due to T lymphocyte mediated destruction of stem cells resulting in pancytopenia with a cellular bone marrow and normal cell cytogenetics. The causes of aplastic anaemia may be inherited or acquired. The causes and the diagnostic approach, along with spectrum of severity of this disorder is discussed in this presentation. A detailed discussion of the management options, along with pharmacological therapy and supportive therapy in these cases is also discussed. The treatment options include, in addition to a stem cell transplant, anti-thymocyte globulin, cyclosporine, methyprednisolone and eltrombopag (for patients who have failed treatment on combined modality therapy with ATG and cyclosporine)
-Intrapartum antibiotic prophylaxis for mothers colonized with group B Streptococcus can prevent early-onset neonatal disease. Adequate prophylaxis consists of ampicillin, penicillin, or cefazolin for ;::4 hours before delivery. Regardless of intrapartum treatment, all high-risk infants must be observed for ;::49 hours. A complete blood count with differential and blood culture are indicated if the infant is preterm <37 weeks or was exposed to prolonged rupture of membranes.>18 hrs.
A deep cut on the palm side of your fingers, hand, wrist, or forearm can damage your flexor tendons, which are the tissues that help control movement in your hand. A flexor tendon injury can make it impossible to bend your fingers or thumb.
The most popular and one of the principal stains in histology is hematoxylin and eosin stain. It gives us an overview of the tissue and its structure. Hematoxylin binds with basophilic structures – for example DNA and RNA. So we can observe nuclei stained in blue or purple color. Eosin binds to acidophilic substances such as positively charged amino acid side chains. So as the result cytoplasm is pink or orange. All samples in laboratory are stained with H&E. There are several different types of hematoxylins and eosins used in histology which will give us different results.
In this video you will see, how we stain slides with different types of hematoxylins and eosins. Finally, we will compare the results.
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Haemorrhoids is one of the most common problems seen in surgical OPD. Open haemorrhoidectomy has remained the gold standard for a long time with a high post-operative morbidity. The quest for a better understanding of the pathology of haemorrhoids resulted in the evolvement of stapler haemorrhoidopexy. Our aim is to study the efficacy of stapler haemorrhoidopexy with regards to role of immediate post-operative morbidity. A prospective study of 50 patients (n = 50) with the second- and third-degree symptomatic haemorrhoids was done. The mean age of the patients was 44.1 years. Fourteen patients had co-morbid conditions. The average duration of the operation was 29 min. Patients with the second-degree haemorrhoids had higher rate of complication. The complication rate was 32%. Three patients had urinary retention. Two patients had minor bleeding, and one patient experienced transient discharge. The mean analgesic requirement was 2.4 tramadol, 50 mg injections. Ten patients had significant post-operative pain. Average length of hospital stay was 2.7 days. There were no symptomatic recurrences till date.
Although most women have had enough experience to know how to pleasure a man in the bedroom, but you can be sure that are several girls who would be virgins when you first take them to bed. Though most Indian men actually prefer to make love with a virgin. There are also numerous men who dislike the idea due to the pressure of making love to someone with no experience. So if you happen to be dating a virgin then there are a few important things that you should always keep in mind when you take her to bed. Though you have made love to different women before, you need to understand that this one being a virgin will know little or nothing about what is expected of her in bed. Because she will be anxious and nervous, you have to be all the more careful to ensure that she gets to enjoy her first time with you. Kiss her Whether you are doing it with a virgin or someone with a record that would put Pam Anderson to shame, you should take your time to make love to her just with your lips. Use your lips with passion, and kiss her parts that other guys tend to ignore. Kiss her lips, her hips, her shoulders, her hands, nuzzle her ears - parts which aren’t necessary sexual. Give your girl a hand Okay this one may look straight out of a B-grade south Indian movie, but starting off with a sensual full body massage is an excellent way of warming her up. So use some nice aromatic oils like lavender or Yang-Yang to massage her body. If you are more experienced, you would be aware the various erogenous zones of a woman’s body. Start with the nape of her neck and slowly work your way down to her back, gently knead her breasts and play with her nipples, gently flick at them and manipulate them to erection. Get her to lie on her stomach and massage her inner thighs. Lovingly caress her buttocks and move your hands close to her valley of pleasure. She might be too shy to tell you, but her ultimate pleasure point would be dying for your attention. Gently, stroke her outer lips or the labia. Whatever, apprehensions or fears she may have had about sex will all disappear once your finger start creating magic in her nether regions. Never criticise her Remember, she has never felt a man’s body before, which essentially means that when she tries to explore your body you may not necessarily enjoy it. So let her hold your penis and fondle it, let her lick and nibble you and tickle you body. You may not find her amateurish attentions very arousing but don’t make her feel like an amateur in bed. If she does something right let her know how much you are enjoying it. Guide her fingers to your pleasure points and tell her what you would like a girl to do in bed. Being the more experienced partner you should be like her loving mentor, and teach her the intricacies of pleasuring a man. Make her touch herself While she may or may not have masturbated before, by getting her to touch herself you would be able to make her feel the unknown. Tell her how badly you want to see her masturbate. The idea is open her to own sexuality. Its time to penetrate When you think that she is finally ready to be penetrated, enter her as gently as possible. Also make sure that she is producing enough lubrication to facilitate the act. Keep your strokes slow and shallow and avoid pushing too deep during your first few strokes. If you are able to make her feel comfortable and safe, any pain that she may experience in the beginning will soon disappear, and be replaced by moans of ecstasy. The first time can be nerve racking for most men. Just remember how nervous you were when you had sex for the first time. So when your take your virginal girlfriend to bed for first time makes the experience as pleasurable for her as possible.