Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target guanines. Cisplatin can bond more tightly with nitrogen because nitrogen balances the platinum charge more effectively than chlorine. It is this adduct-induced DNA bend that allows binding of proteins which contain the high mobility group, HMG domain. Once the protein is bound to the DNA, it inserts a wedge-like phenyl group of phenylalanine 37 into the widened minor groove created by the bend. The tightly bound HMG protein causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, Cisplatin can be thought of as a monkey wrench in the DNA repair system. With the HMG protein bound to the DNA, the modified strand is not repaired properly and so the cell dies. The success of Cisplatin depends on its ratio of efficacy between cancerous and healthy cells.

: Frederick Lang, M.D., and Jeffrey Weinberg, M.D., neurosurgeons at MD Anderson Cancer Center, answer frequently asked questions about what to expect when you’re having brain tumor surgery.

Learn more about the MD Anderson Brain and Spine Center: www.mdanderson.org/brainandspine

Request an appointment at MD Anderson by calling 1-877-632-6789 or online: https://my.mdanderson.org/RequestAppointment

Watch that video to know the Difference Between White and Clear Sperm

Renal artery stenosis is a narrowing of arteries that carry blood to one or both of the kidneys. Most often seen in older people with atherosclerosis (hardening of the arteries), renal artery stenosis can worsen over time and often leads to hypertension (high blood pressure) and kidney damage.

A video showing the repair of episiotomy

Hemorrhoidectomy Operation Video

Tears Of Abortion - Story of an aborted baby,

Midline Episiotomy

A video showing breast examination after breast implants

UPMC liver surgeons are among the most experienced in the world in performing minimally invasive liver surgery. Most patients benefit from less trauma and pain, minimal scarring, a shorter hospital stay, and faster recovery than from traditional surgery.
To learn more, please visit https://www.upmc.com/services/....liver-cancer/treatme

Colorectal cancer (also known as colon cancer, rectal cancer or bowel cancer) is the development of cancer in the colon or rectum (parts of the large intestine). It is due to the abnormal growth of cells that have the ability to invade or spread to other parts of the body. People with HNPCC tend to develop colon cancer before age 50. Familial adenomatous polyposis (FAP). FAP is a rare disorder that causes you to develop thousands of polyps in the lining of your colon and rectum. People with untreated FAP have a greatly increased risk of developing colon cancer before age 40.

The is a time lapse video animation of a complicated ear infection with a ruptured eardrum causing drainage with eventual healing. The video also shows why a period of hearing loss and clogged/muffled ear sensation may occur.

What is vascular access? What are the different types of accesses for hemodialysis? Does vascular access require surgery? Adina Voiculescu, M.D., FASDIN, General and Interventional Nephrologist at Brigham and Women's Hospital and Assistant Professor at Harvard Medical School, discusses the different types of vascular access, such as AV fistulas and AV grafts, and how to stay healthy while on hemodialysis.

Subscribe Link: https://www.youtube.com/channe....l/UCYrLjATd88gPwIKnt

0:00 - Intro
0:29 - Peritoneal dialysis & Hemodialysis
0:44 - Types of access to perform dialysis
1:48 - Recommendations

About Mass General Brigham:
Mass General Brigham combines the strength of two world-class academic medical centers, five nationally ranked specialty hospitals, 11 community hospitals, and dozens of health centers. Our doctors and researchers accelerate medical breakthroughs and drive innovations in patient care. They are leaders in medical education, serving as Harvard Medical School faculty and training the next generation of physicians. Mass General Brigham’s mission is to deliver the best, affordable health care to patients everywhere. Together, we transform the health of our communities and beyond.

#MassGeneralBrigham #MGB #Hemodialysis

Visit Mass General Brigham: https://www.massgeneralbrigham.org/

Find us on social:
Twitter: https://twitter.com/MassGenBrigham
Instagram: https://www.instagram.com/massgeneralbrigham/
Facebook: https://www.facebook.com/MassGeneralBrigham/
LinkedIn: https://www.linkedin.com/compa....ny/mass-general-brig

Mass General Brigham:
https://www.youtube.com/massgeneralbrigham

Hemodialysis: Types of Accesses for Kidney Dialysis and How to Stay Healthy | Mass General Brigham
https://youtu.be/_bxLpudpqnc

Robot-Assisted Laparoscopic Rectal resection for Endometriosis.Operation performed by D.Vitobello, director of divisione of Gynaecology, and G.Baldazzi,director of Surgical department. Abano Terme Hospital Padova (Italy)

this video shows how the adult circumcision is easy by the alisklamp

How Male to Female Sex Gender Reassignment Surgery Really Works

In patients age ;::25, HPV DNA testing is the preferred next step in management if the initial cytology shows ASC-US. In this method, samples are collected for both cytology and reflex HPV DNA. If cytology results are positive, HPV DNA testing is performed. If cytology results are negative, the sample for HPV DNA is discarded. HPV DNA testing along with Pap smear at 3 years is recommended if initial cytology shows ASC-US but HPV DNA testing is negative

Ganglion cysts are noncancerous lumps that most commonly develop along the tendons or joints of your wrists or hands. They also may occur in the ankles and feet. Ganglion cysts are typically round or oval and are filled with a jellylike fluid. Small ganglion cysts can be pea-sized, while larger ones can be around an inch (2.5 centimeters) in diameter. Ganglion cysts can be painful if they press on a nearby nerve. Their location can sometimes interfere with joint movement. If your ganglion cyst is causing you problems, your doctor may suggest trying to drain the cyst with a needle. Removing the cyst surgically also is an option. But if you have no symptoms, no treatment is necessary. In many cases, the cysts go away on their own.

Pediatric surgeons at Texas Children’s Hospital West Campus perform general surgical procedures such as circumcisions, removal of foreign objects, hernia repair, and suturing of minor lacerations. While more complex surgeries take place at the Texas Children’s Main Campus, pre-operative and follow-up outpatient care for those procedures is available at the West Campus.

Everything about Texas Children’s Hospital West Campus is dedicated to the health and wellness of children. As greater Houston's first suburban hospital designed exclusively for children, we offer the expert care you've come to trust from Texas Children's Hospital coupled with a location that's convenient and accessible for area families. Our facility is located just off the westbound feeder road of the Katy Freeway (at I-10 and Barker Cypress).

For more information about Texas Children's Hospital West Campus, visit http://www.texaschildrens.org/....Locate/In-the-Commun

Meet Dr. Allen Milewicz, chief of community surgery at Texas Children's West Campus
https://www.youtube.com/watch?v=uMoCdipuKfA&index=16&list=PLiN68C9rloPBD-E9ChWhVy73h7V3SEMlm

Ankylosing spondylitis is an inflammatory disease that, over time, can cause some of the vertebrae in your spine to fuse. This fusing makes the spine less flexible and can result in a hunched-forward posture. If ribs are affected, it can be difficult to breathe deeply. Ankylosing spondylitis affects men more often than women. Signs and symptoms typically begin in early adulthood. Inflammation also can occur in other parts of your body — most commonly, your eyes. There is no cure for ankylosing spondylitis, but treatments can lessen your symptoms and possibly slow progression of the disease.