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This is a diabetic foot ulcer. The patient reportedly went on vacation and noticed this ulcer upon their return. Debridement (removal of damaged tissue) to the level of healthy bleeding tissue is medically necessary as damaged tissue acts an impediment to wound healing. Due to their diabetic neuropathy, they did not feel any pain or indication that a wound was forming. This ulcer appeared to have penetrated to the level of subcutaneous tissue or even fascia, but turned out to be much deeper than that. These are serious wounds and are the beginnings of what lead to foot and leg amputations if they are not treated promptly by your healthcare provider, AKA Podiatrist.
Stress-related mucosal disease (SRMD) is an acute, erosive gastritis representing conditions ranging from stress-related injury to stress ulcers (1, 2). Stress-related injury is superficial mucosal damage that presents primarily as erosions, whereas stress ulcers are deep, focal mucosal damage penetrating the submucosa with high risk for gastrointestinal bleeding (2, 3). Mucosal damage has been reported to occur during the first 24 hours of hospital admission in 75% to 100% of intensive care unit (ICU) patients (4, 5). Clinically important gastrointestinal bleeding can cause hemodynamic instability and increase the need for red blood cell transfusions (1). Significant bleeding may also increase the length of stay in the ICU and mortality (1).
A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: https://kikoxp.com/posts/5084 (dermpath) & https://kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology)
Topics discussed:
Epidermis:
Layers of epidermis: 0:10
Melanocytes vs Keratinocytes: 5:16
Langerhans cells: 10:10 & 33:30 & 57:30
Dermis:
Papillary and reticular dermis: 11:50
Three types of white empty spaces on a slide: vessels, glands/ducts/cysts, or artifact: 15:25
Blood vessels & nerves: 18:24 & 48:50 & 58:59
Arrector pili & other dermal smooth muscle: 20:00
Adnexal:
Sebaceous gland: 21:10
Hair follicle 23:14
Eccrine sweat glands and ducts 24:45 & 50:00
Gland/duct vs blood vessel 27:20 & 48:50
Apocrine glands: this video https://kikoxp.com/posts/7837 (at 12:30)
Acrosyringium: this video https://kikoxp.com/posts/7837 (at 10:00)
Three types of pink bundles: smooth muscle, nerve, dense connective tissue: 27:50
Acral skin (palm sole) with contact dermatitis 29:37
Parakeratosis 30:00
Perivascular lymphocytes 30:40
Eosinophils vs neutrophils 31:20
Spongiosis with desmosome keratinocyte spines 32:10
Spongiotic vesicles with Langerhans cells 33:30
Normal acral skin (palm & sole) with stratum lucidum 34:20
Normal glomus body/apparatus (canal of Sucquet-Hoyer) 35:40
Nerve 36:46 & 51:50
Adipose tissue (white fat cells) in subcutis with Lochkern 37:55
Normal scalp skin with large anagen hair follicles: 39:30
Hair follicle anatomy (bulb/matrix, inner root sheath, outer root sheath, hair shaft, isthmus, infundibulum): 40:55 (labeled images):
https://kikoxp.com/posts/3661 & https://kikoxp.com/posts/7899
Pacinian corpuscle 50:40
Meissner corpuscle 1:02:28
Dense regular connective tissue (Fascia/Tendon/Ligament) vs Smooth Muscle 53:00
Basic Normal Skin Immunohistochemistry:
-cytokeratin in epidermis: 55:33
-S100 in melanocytes and Langerhans cells and adipocytes: 57:30
-Desmin in smooth muscle (arrector pili and blood vessels): 58:59
-CD31 in endothelial cells of blood vessels: 59:33
-SOX-10 in melanocytes: 1:00:40
Digit/Finger/Toe histology (amputation for subungual acral melanoma) 1:04:10 & 1:08:30
-bone 1:05:40
-glomus body 1:05:15
-tendon/ligament 1:06:10
-artery 1:06:58
-fingernail/toenail 1:08:54
-acrosyringium 1:10:45
Solar elastosis (what wrinkles look like microscopically!) 1:11:50
Other videos you might like:
Tendon vs Nerve Histology Made Simple with the Ramen Noodle Sign (of Fulton) video: https://kikoxp.com/posts/4466
Melanocytes vs Keratinocytes made easy video: https://kikoxp.com/posts/3802
Blood Vessel vs Gland vs Artifact Made Easy video: https://kikoxp.com/posts/4808
The basic normal structures of the skin discussed and described by a dermatopathologist. This material is intended for use by medical students, junior pathology or dermatology residents, or for anyone else studying normal human histology. Special thanks to two of my medical students at UAMS for helping make this video possible. Miki Lindsey convinced me that I really needed to sit down and record this video. Akash Patel took time to edit the video and make it ready for YouTube. My sincere thanks to both of them for helping me overcome procrastination.
Huge thanks to Abigail Cline, a medical student at Medical College of Georgia, for volunteering to type a transcript of this ENTIRE video (over 14,000 words!) so that I could provide closed caption subtitles for those with hearing impairments and for those who may need assistance in understanding spoken English (particularly given how quickly I speak!). You can access a text version of her transcript of my video here: https://kikoxp.com/posts/5390
Correction - I made a mistake in the video. I said that sebaceous gland secretions are turned into smelly substances by bacteria and that this makes body odor. That is incorrect. That is actually true of APOCRINE gland secretions not sebaceous secretions.
Also, in the past I used "keratinocyte" and "squamous cell" interchangeably (this is because in dermatopathology, we see and talk about squamous cell carcinomas all the time, and those tumors are composed of keratinocytes). But technically, in normal skin histology, "squamous cell" refers only to the flattened keratinocytes in the superficial epidermis. Thankfully, a histology PhD colleague pointed this out to me and corrected my lazy nomenclature!
Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: http://bit.ly/2Te2haB
This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.
Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.
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Histological features and cellular biology of exocrine glands. This video is a part of our Histology Video Course (https://youtube.com/playlist?l....ist=PLnr1l7WuQdDynxT
Additional YouTube Content
Biochemistry videos: https://youtube.com/playlist?l....ist=PLnr1l7WuQdDzCUC
Anatomy Videos: https://youtube.com/playlist?l....ist=PLnr1l7WuQdDz2dK
DaVinci Cases Videos: https://youtube.com/playlist?l....ist=PLnr1l7WuQdDyJUl
The DaVinci Hour Podcast: https://youtube.com/playlist?l....ist=PLnr1l7WuQdDwSm9
DaVinci Academy Website: https://www.dviacademy.com/
An ectopic pregnancy (EP) is a condition in which a fertilized egg settles and grows in any location other than the inner lining of the uterus. The vast majority of ectopic pregnancies are so-called tubal pregnancies and occur in the Fallopian tube.
© 2023 Elsevier. All rights reserved. Histologically the cervix is different from the rest of the uterus and also has a mucosa that doesn’t shed during menstruation.
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Bone marrow examination refers to the pathologic analysis of samples of bone marrow obtained by bone marrow biopsy (often called a trephine biopsy) and bone marrow aspiration. Bone marrow examination is used in the diagnosis of a number of conditions, including leukemia, multiple myeloma, anemia, and pancytopenia. The bone marrow produces the cellular elements of the blood, including platelets, red blood cells and white blood cells. While much information can be gleaned by testing the blood itself (drawn from a vein by phlebotomy), it is sometimes necessary to examine the source of the blood cells in the bone marrow to obtain more information on hematopoiesis; this is the role of bone marrow aspiration and biopsy.
Olympus has extended the value of its award-winning combined surgical energy device, THUNDERBEAT, to open surgical procedures. Watch Dr. Francois Blaudeau master use of THUNDERBEAT Open Extended Jaw (OEJ) in a total abdominal hysterectomy.
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How to Improve Sexual Health or Stamina part 4 All Solution of Male Disorder Male Infertility Diagnostic and Treatment Re-Slim Care Latest Technology in Pakistan Dr. Aslam Naveed is a well known sexologist in Pakistan. He has treated more than 1 Lac patients since last 30 years of clinical Practice in sexology, he knows how to help the people facing sexual disorders. Contact: 02134965050, 03432821919 www.sexologistpakistan.com https://www.facebook.com/menssexcareclinic/ https://youtu.be/_fRbtwWtLoE Part 1 https://youtu.be/S17bCnwCLuI Part 2 https://youtu.be/CPAXxkdz7mM Part 3 https://youtu.be/YlsdBZJ4prg Part 4 https://youtu.be/fylxbK4azvs Part 5 https://youtu.be/Zb8TcdgJ7Io Part 6 https://youtu.be/0wbDDNAwsmo Part 7 https://youtu.be/gHDmwfsMgTw Part 8 https://youtu.be/IasXoRKUlV4 Part 9 ADDRESS: Men’s Care Modern Hospital, Opposite, Safari Park, University Road, Karachi, Pakistan.
In this video, Dr Dhaval Patel, the best brain & spine surgeon in Surat South Gujarat, is performing Brain Hemorrhage Surgery. The Brain Hemorrhage Surgery was successfully done by the best neurosurgeon Dr Dhaval Patel in the midnight in Surat, South Gujarat.
Dr Dhaval Patel is the best and experienced brain & spine surgeon in Adajan, Vesu, Parvat Patiya, Surat, South Gujarat. Dr Dhaval is the expert of treatments and surgery for brain problems and spine problems.
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Dr. Dhaval Patel is an excellent neurosurgeon in Surat, South Gujarat. He is a Brain and Spine Surgeon; he is a reputable Neurosurgeon in Surat, South Gujarat. He has been practicing for the past five years. Till now, he has done 2500+ minor and major surgeries.
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Specialist in Brain & Spine Surgery
M.S.DNB (Neurosurgery - New Delhi)
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Surat Neuro Clinic Majura Gate, Ring Road, Surat.
Unity Hospital Parvat Patiya, Surat
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