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Part 2: Translational Neuroscience of Excessive Daytime Sleepiness (EDS), Fatigue and Hype
Part 2: Translational Neuroscience of Excessive Daytime Sleepiness (EDS), Fatigue and Hype Mohammad Torabi Nami 8,883 Views • 2 years ago

Sleepiness, tiredness and fatigue are complaints which must be thoroughly analyzed to eliminate blur and ambiguity.
Physiological sleepiness (“sleep pressure”) increases while being awake and additionally underlies the circadian rhythm with a lower threshold to fall asleep during night time.
Excessive daytime sleepiness (EDS) is considered normal only after sleep deprivation. Clinically, EDS manifests by frequents daytime napping and/or reduced alertness with automatic behavior or - in its extreme form - in recurrent attacks of sudden, uncontrollable compulsion to sleep also in inappropriate situations (= “sleep attacks”).
EDS is “objectively” addressed by measuring the mean sleep latency to four to five nap opportunities throughout the day using the multiple sleep latency test (MSLT) or the maintenance of wakefulness test (MWT).
EDS denotes both, a ready entrance into sleep as well as difficulty in staying awake during daytime or accordingly in inappropriate situations. These two partially independent aspects of EDS are separately assessed by the “passive” MSLT and the “active” MWT respectively.
For that reason the MSLT and MWT only weakly correlate with each other when tested over a broad range of patients with EDS. It is important to keep in mind, that these tests are importantly influenced by a great variety of factors such as mood, anxiety, and motivation.
“Vigilance” comprises wakefulness, alertness and attention and therefore is more than just the reciprocal to sleepiness. Cognitive performance tasks such as Steer Clear Reaction Time Test (SCRTT) or driving simulators require the complete integrity of vigilance to achieve normal results. Hypersomnia is usually broadly defined as the combination of abnormally prolonged night-time sleep (regularly >10 h) with EDS during ≥1 months.
On the other hand, the term hypersomnia has also been used in a narrower scene for the isolated abnormality of a prolonged night-time sleep need (>10 h). “Tiredness”, also in colloquial language often used for sleepiness, in a broader sense also describes the feeling of lack of energy, motivation and initiative.

These patients seek rest rather than sleep. They often cannot fall asleep when given the opportunity in spite of feeling tired, and hence, in an MSLT, do not show an abnormally short sleep latency. Furthermore, tiredness (and fatigue) as opposed to sleepiness has a mental (“central”) and physiological (bodily or “peripheral”) component, which the patients can readily distinguish. Patients with insomnia, mild sleep apnea syndrome, or depression rather suffer from mental tiredness than sleepiness during the day.
The simple subjective self-assessment using the Epworth Sleepiness Scale (ESS) quite reliably differentiates between sleepiness and mental tiredness (without sleepiness), which makes it a widely used test. The term “fatigue” is also heterogeneously used.
In physiology the “fatigue” implied a “time on task performance decrement” to describe decreasing muscle force during a sustained physical effort. In clinical medicine one distinguishes physical (“peripheral”) from mental (“central”) fatigue and the term usually denotes a chronic and more abnormal situation than tiredness.
In a broad sense “fatigue” implies a deficiency in coping satisfactorily with mental and physical work load. The chronic fatigue syndrome entails both mental as well as a physical fatigue (so called “leaden paralysis” of limbs). Depressive states are often associated with insomnia and fatigue, but there are also cases with hypersomnia rather than insomnia ( non organic hypersomnia , “atypical depression” or “hypersomnolent depression”)
Sometimes these patients have a tendency to spend much of the day lying in the bed without actually sleeping (so called clinophilia). The basic and clinical aspects of fatigu

Sports Medicine Animation / Yoga
Sports Medicine Animation / Yoga Landging 5,505 Views • 2 years ago

http://www.landging.com/accident-animation-sports-injury-yoga.html
This accident animation demonstrates sports injury in yoga practice.

digital ulcer examination part III
digital ulcer examination part III rzahora 5,950 Views • 2 years ago

How to diagnose digital ulceration in out patient clinic.part III

Tubal Ligation Procedure surgery
Tubal Ligation Procedure surgery maronesc 11,919 Views • 2 years ago

bilateral tubal ligation as modified Pomeroy technique during a C-Section

Suffering from Sleeplessness?
Suffering from Sleeplessness? Info4YourLife 4,204 Views • 2 years ago

Having trouble achieving a good night’s sleep? A few easy tips for your daily routine can help you get the rest you need.

Breast Expanders 
Breast Expanders  tom albert 4,570 Views • 2 years ago

AirXpanders Inc. designs, manufactures and distributes the revolutionary AeroFormTM Patient Controlled Tissue Expander. A first for women who choose reconstructive surgery following a mastectomy, the AeroForm tissue expander does not use intrusive and painful saline injections via syringe needles. The AeroForm patient controlled tissue expander utilizes a needle-free inflation system via a patient-controlled handheld device, which releases specified amounts of air in the form of carbon dioxide

Open vs. Closed Rhinoplasty Boca Raton FL - Dr Arthur G Handal, MD
Open vs. Closed Rhinoplasty Boca Raton FL - Dr Arthur G Handal, MD Arthur Handal 3,052 Views • 2 years ago

Dr. Arthur Handal explains both an open and closed approach to a Rhinoplasty and which is more effective, in his opinion.

QuickLift Mini Facelift vs Full Facelift, Boca Raton Florida
QuickLift Mini Facelift vs Full Facelift, Boca Raton Florida Arthur Handal 2,888 Views • 2 years ago

Dr. Arthur Handal explains how and why your surgeon might suggest less or more than the procedure you originally planned for.

Hymenoplasty / Hymen Repair Surgery Delhi
Hymenoplasty / Hymen Repair Surgery Delhi Dr Narendra Kaushik 6,374 Views • 2 years ago

Best and 100% Successful Hymen Repair Surgery in Delhi with Latest Ultrafine Hymen repair Technology. 100% successful , Secure and Private. for more information visit: http://www.olmeccosmeticsurgery.com/best-hymenoplasty-surgery-india-delhi/

Common health concerns for seniors
Common health concerns for seniors Home Care Assistance South Jersey 2,887 Views • 2 years ago

Health disorders are part of life when you are getting older , Some problems are life-threatening, while others lower the quality of life. The good news is that these Health disorders can be managed effectively.
homecareassistancesouthjersey.com

Amputation of the Index Finger
Amputation of the Index Finger Surgeon 25,307 Views • 2 years ago

An amputation is the removal of an extremity or appendage from the body. Amputations in the upper extremity can occur as a result of trauma, or they can be performed in the treatment of congenital or acquired conditions. Although successful replantation represents a technical triumph to the surgeon, the patient's best interests should direct the treatment of amputations. The goals involved in the treatment of amputations of the upper extremity include the following : Preservation of functional length Durable coverage Preservation of useful sensibility Prevention of symptomatic neuromas Prevention of adjacent joint contractures Early return to work Early prosthetic fitting These goals apply differently to different levels of amputation. Treatment of amputations can be challenging and rewarding. It is imperative that the surgeon treat the patient with the ultimate goal of optimizing function and rehabilitation and not become absorbed in the enthusiasm of the technical challenge of the replantation, which could result in poorer outcome and greater financial cost due to lost wages, hospitalization, and therapy.

Management of Shoulder Dystocia
Management of Shoulder Dystocia Scott 44,726 Views • 2 years ago

Shoulder dystocia is a specific case of obstructed labour whereby after the delivery of the head, the anterior shoulder of the infant cannot pass below, or requires significant manipulation to pass below, the pubic symphysis. It is diagnosed when the shoulders fail to deliver shortly after the fetal head. Shoulder dystocia is an obstetric emergency, and fetal demise can occur if the infant is not delivered, due to compression of the umbilical cord within the birth canal. It occurs in approximately 0.3-1% of vaginal births. Contemporary management of shoulder dystocia requires a calm operator and a well-thought-out plan of action. It is imperative that if not already present, help is summoned immediately after shoulder dystocia is recognized. This help may include additional nursing staff, an anesthesiologist, a pediatrician or neonatologist and an additional obstetrician or midwife. Future coordination may demonstrate that rapid response teams are best suited to attend to this emergency.

First Bilateral Hand Transplant in a Child: Zion's Story
First Bilateral Hand Transplant in a Child: Zion's Story Surgeon 3,100 Views • 2 years ago

Surgeons at The Children’s Hospital of Philadelphia were the first to perform a bilateral hand transplant on a child. Our research and work in this groundbreaking field of medicine led us to establish the Hand Transplantation Program. Combining the expertise of the Penn Transplant Institute and the Hospital’s Division of Plastic and Reconstructive Surgery and Division of Orthopedics, the program aims to improve quality of life for children who may benefit from this procedure.

Fifth Disease
Fifth Disease samer kareem 7,314 Views • 2 years ago

Fifth disease is a mild rash illness caused by parvovirus B19. This disease, also called erythema infectiosum, got its name because it was fifth in a list of historical classifications of common skin rash illnesses in children. It is more common in children than adults. A person usually gets sick with fifth disease within 4 to 14 days after getting infected with parvovirus B19.

Treatment and Management of Type 2 Diabetes
Treatment and Management of Type 2 Diabetes samer kareem 2,071 Views • 2 years ago

protecting the body from damage caused by hyperglycemia cannot be overstated. In the United States, 57.9% of diabetic patients have one or more diabetes complications, and 14.3% have three or more.1 Strict glycemic control is the primary method of reducing the development and progression of microvascular complications, such as retinopathy, nephropathy, and neuropathy. Aggressive treatment of dyslipidemia and hypertension decreases macrovascular complications.2-4 Glycemic Control There are two primary techniques available for physicians to assess the quality of a patient’s glycemic control: self-monitoring of blood glucose (SMBG) and interval measurement of hemoglobin A1c (HbA1c).

CROUP
CROUP samer kareem 1,636 Views • 2 years ago

Croup refers to an infection of the upper airway, which obstructs breathing and causes a characteristic barking cough. The cough and other symptoms of croup are the result of swelling around the vocal cords (larynx), windpipe (trachea) and bronchial tubes (bronchi). When a cough forces air through this narrowed passage, the swollen vocal cords produce a noise similar to a seal barking. Likewise, taking a breath often produces a high-pitched whistling sound (stridor). Croup typically occurs in younger children. Croup usually isn't serious and most cases can be treated at home.

Top 10 Shocking Before And After Drug Use Photos
Top 10 Shocking Before And After Drug Use Photos samer kareem 1,577 Views • 2 years ago

Top 10 Shocking Before And After Drug Use Photos

Leg Ulcers
Leg Ulcers samer kareem 1,916 Views • 2 years ago

A leg ulcer is simply a break in the skin of the leg, which allows air and bacteria to get into the underlying tissue. This is usually caused by an injury, often a minor one that breaks the skin. In most people such an injury will heal up without difficulty within a week or two. However, when there is an underlying problem the skin does not heal and the area of breakdown can increase in size. This is a chronic leg ulcer.

Priapism
Priapism samer kareem 4,044 Views • 2 years ago

Priapism is a prolonged erection of the penis. The persistent erection continues hours beyond or isn't caused by sexual stimulation. Priapism is usually painful. Although priapism is an uncommon condition overall, it occurs commonly in certain groups, such as people who have sickle cell anemia. Prompt treatment for priapism is usually needed to prevent tissue damage that could result in the inability to get or maintain an erection (erectile dysfunction). Priapism is most common in men in their 30s.

Nipple Sensation After Breast Augmentation
Nipple Sensation After Breast Augmentation samer kareem 1,936 Views • 2 years ago

Nipple Sensation After Breast Augmentation

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