Top videos
The hepatitis E virus, responsible for major epidemics of viral hepatitis in subtropical and tropical countries, was cloned only 7 years ago.1 Hepatitis E was found to belong to the family of Caliciviridae, which includes the Norwalk virus—a common cause of gastroenteritis in humans—and consists of a single, plus-strand RNA genome of approximately 7.2 kb without an envelope (Fig. 1). The virus contains at least three open reading frames encoding viral proteins against which antibodies are made on exposure. These antibodies, especially those against the capsid protein derived from the second open reading frame2 and a protein of unknown function derived from the third open reading frame, are detected by currently available serologic assays. Retrospective studies on stored sera of past epidemics of viral hepatitis in Mexico, Africa, Afghanistan, Pakistan, India, Bangladesh, Burma, Nepal, and Borneo have revealed that all were caused by strains of hepatitis E. In addition, hepatitis E was found to be responsible for the hepatitis epidemic in the southern part of Xinjiang, China, in which 120,000 persons became infected between September 1986 and April 1988.3 Hepatitis E predominantly affects young adults (15 to 40 years old). The symptoms of hepatitis E are similar to those of hepatitis A. Frequently, a prodrome consisting of anorexia, nausea, low-grade fever, and right upper abdominal pain is present 3 to 7 days before jaundice develops. Aminotransferase levels peak (usually between 1,000 and 2,000 U/L) near the onset of symptoms; bilirubin levels (10 to 20 mg/dL) peak later. Jaundice usually resolves after 1 to 2 weeks. In about 10% of cases, the disease is fulminant—especially in pregnant women, among whom mortality rates as high as 20% due to hemorrhagic and thrombotic complications have been reported. No evidence has suggested that hepatitis E can cause chronic infection. Transmission is by the fecal-oral route, predominantly through fecally contaminated drinking water supplies. In addition, however, preliminary reports have suggested transmission of the hepatitis E virus through blood transfusions. Volunteer studies confirmed the presence of the virus in serum and feces before and during clinical disease.4 The virus is shed into feces approximately 1 week before symptoms develop. The incubation period varies from 2 to 9 weeks (mean duration, approximately 45 days). Until now, a few reports had described symptomatic hepatitis E acquired in Europe;5, 6 all patients with symptomatic hepatitis E in the United States were travelers returning from Mexico, Africa, or the Far East, in whom hepatitis E developed after their return home.7 In this issue of the Mayo Clinic Proceedings (pages 1133 to 1136), Kwo and associates describe a case of hepatitis E in a man who had not left the United States during the previous 10 years. Specific serologic tests for hepatitis E virus IgG (enzyme immunoassays and a fluorescent antibody blocking assay) and IgM8 (US strain-specific enzyme-linked immunosorbent assay with use of synthetic polypeptides deduced from the viral genome, as shown in Figure 1), developed at Abbott Laboratories (IgG and IgM) as well as at the Centers for Disease Control and Prevention (IgG), were used to prove that the patient indeed had acute hepatitis E. Researchers at Abbott Laboratories have prepared a report that describes most of the viral genome in this patient (Fig. I).8 Their results are interesting because this strain from the United States differs considerably from hepatitis E strains isolated in Mexico, Burma, Pakistan, or China. Furthermore, the sequence of the US strain is highly homologous (98% and 94% homology at the amino acid level to the second and third open reading frames, respectively) to a recently isolated hepatitis E strain from American swine.9 This finding suggests that, in the United States, hepatitis E is a zoonosis with the swine population as one of its hosts. This relationship would confirm earlier studies in Asia, where swine were also found to carry variants of the hepatitis E virus.10 Why are these two recent discoveries important for medicine in the United States? First, other sporadic, locally acquired cases of acute hepatitis may be caused by hepatitis E. Second, these back-to-back discoveries strongly suggest that a common natural host for hepatitis E is present in countries with more moderate climates. Because swine do not seem to experience any symptoms associated with infection and because symptoms in humans can be minor or absent, we now may also have an explanation for the 1 to 2% of positive hepatitis E serologic results in blood donors in the United States,11 Netherlands,12 and Italy,6 countries with large swine staples. Clearly, more research needs to be done to confirm this hypothesis. Third, in countries with more moderate climates, hepatitis E may often result in a subclinical infection. Is this variation in manifestation due to less virulent strains, and do sequence variations determine virulence? Fourth, swine may be used as an animal model for study of the disease as well as vaccine development.
Harper University Hospital has been accredited as a Bariatric Center of Excellence by the American Society of Bariatric Surgeons. By employing laparoscopy, this bariatric procedure is minimally invasive and results in quicker recovery time, as well as less scarring. ~ Detroit Medical Center
A fractured rib is usually a result of a fall or accident. Prolonged coughing and sports with repetitive movement, such as golf, also can cause a rib fracture. Symptoms include pain when taking a deep breath, pressing on the injured area, or bending or twisting the body. In most cases, fractured ribs usually heal on their own in one or two months. Pain relievers can make it easier to breathe deeply.
After Sammyra’s knee injury, Marvin Smith, MD, orthopaedic surgeon at Memorial Sports Medicine Center, helped her get back on the volleyball court and playing pain free. Following a thorough examination, meniscus surgery and rehabilitation got Sammyra back to playing with her college team within two months. Learn more about how Memorial Sports Medicine Center helps athletes move forward at MHS.net/SportsMedicine.
To learn more about Dr. Smith, visit his physician profile page at: https://www.mhs.net/physicians/s/smith-marvin-k
Click here to get 2 free filet mignons and $15 off your first ButcherBox: https://butcherbox.com/doctormike
Includes FREE Shipping. Be sure to enter your email to access the deal. Thanks to ButcherBox for sponsoring this video.
I’ll teach you how to become to media’s go-to expert in your field. Enroll in The Professional’s Media Academy now: https://www.professionalsmediaacademy.com
Listen to my podcast, @DoctorMikeCheckup here:
YouTube: https://go.doctormikemedia.com..../youtube/channel/The
Spotify: https://go.doctormikemedia.com..../spotify/CheckUpSpot
Apple Podcasts: https://go.doctormikemedia.com..../applepodcast/AppleP
Survivor is coming up on its 43rd season this fall (whaaat??), and with all that reality TV goodness in the can already I knew there would be some medical moments to react to. Turns out, I was right, in that there have been a bunch of ailments on the show over the years! These injuries span the entire length of the whole series, so if you're a long time Survivor and Jeff Probst fan, this one is for you!
I LOVE reading your comments and take your suggestions seriously. If there’s a subject you want me to discuss or something you’d like for me to react to, leave a comment down below. Many of my videos have been born out of suggestions directly from you, so don’t hold back!
-Doctor Mike Varshavski
Help us continue the fight against medical misinformation and change the world through charity by becoming a Doctor Mike Resident on Patreon where every month I donate 100% of the proceeds to the charity, organization, or cause of your choice! Residents get access to bonus content, an exclusive discord community, and many other perks for just $10 a month. Become a Resident today:
https://www.patreon.com/doctormike
Please SUBSCRIBE for new videos every Wednesday afternoon and Sunday morning! https://goo.gl/87kYq6
Let’s connect:
IG https://goo.gl/41ZS7w - Doctor Mike
Reddit https://www.reddit.com/r/DoctorMike/
Twitter https://goo.gl/kzmGs5 - Real Doctor Mike
Facebook https://goo.gl/QH4nJS - Real Doctor Mike
Contact Email: DoctorMikeMedia@Gmail.com
Executive Producer: Doctor Mike
Production Director and Editor: Dan Owens
Managing Editor and Producer: Sam Bowers
Editor and Designer: Caroline Weigum
* Select photos/videos provided by Getty Images *
** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional **
ormal sperm densities range from 15 million to greater than 200 million sperm per milliliter of semen. You are considered to have a low sperm count if you have fewer than 15 million sperm per milliliter or less than 39 million sperm total per ejaculate.
The journey of egg and sperm. There are a lot of casualties (deaths) among the sperm as they swim toward the egg. First, many get lost in the maze of a woman's uterus where they also have to contend with acidic vaginal secretions.
How to Use a Menstrual Cup Fold and hold. Always start by washing your hands. ... Insert and ensure. As with tampons, gently insert the folded cup into your vagina, tilting it back to the base of your spine. ... Use it up to twelve hours. ... Remove and empty. ... Re-insert.