Endoscopic resection of a large right concha bullosa.

Multiple sclerosis (MS) is a disease of the central nervous system estimated to affect 2.3 million people worldwide. It is a chronic disease in which the immune system abnormally attacks the insulation and support around the nerve cells (myelin sheath) in the brain, spinal cord and optic nerves, causing inflammation and consequent damage. MS is a leading cause of non-traumatic disability in young people, usually striking between 20 and 40 years of age. There is no cure for MS, but research continues to better understand and treat the disease.

The vast majority of glucocorticoid activity in most mammals is from cortisol, also known as hydrocortisone. Corticosterone, the major glucocorticoid in rodents, is another glucocorticoid. Cortisol binds to the glucocorticoid receptor in the cytoplasm and the hormone-receptor complex is then translocated into the nucleus, where it binds to its DNA response element and modulates transcription from a battery of genes, leading to changes in the cell's phenotype. Only about 10% of circulating cortisol is free. The remaining majority circulates bound to plasma proteins, particularly corticosteroid-binding globulin (transcortin). This protein binding likely decreases the metabolic clearance rate of glucocorticoids and, because the bound steroid is not biologically active, tends to act as a buffer and blunt wild fluctuations in cortisol concentration.

An animation showing the general principle of Radiofrequency Ablation of Hepatocellular carcinoma HCC.

A new promising technique in saving the lives of patients with cancer of the esophagus. It is minimally invasive and the recovery time is quicker than ever. H. Lee Moffitt Cancer Center

Watch that Ectopic Baby Medical Abortion Surgery

The procedure of Suprapubic Cystostomy

A surgeon creates an arteriovenous fistula by making a connection between an artery (which carries blood away from the heart) and a vein (which carries blood back to the heart). This artificial connection allows the vein to become larger and for the walls of the vein to thicken, a process termed maturation. A mature fistula makes it easier for the vein to be punctured repeatedly for dialysis. Maturation typically takes three to six months to occur, but in rare cases, can take up to a year. This makes advance planning for an arteriovenous fistula important. When a patient is felt to be approximately a year away from requiring dialysis, the patient should be referred for evaluation for possible creation of an arteriovenous fistula.

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An animated video showing an MRI of the brain

Ovarian pregnancy: an unusual location of ectopic pregnancy

Knee replacement involves replacing a knee joint that has been damaged or worn away, usually by arthritis or injury. Find out more here: http://bit.ly/MAdfmE

The content is intended for general information only and does not replace the need for personal advice from a qualified health professional.

Care for Your Knee After Knee Replacement Surgery
In this video, Dr. Mark Hammerberg, provides details on two important activities to help during recovery from knee replacement surgery.

Denver Health's Orthopedics department offers many different types of treatments to help you, including surgical and non-surgical options. To find out if surgery is right for you, visit DenverHealth.org/Orthopedics or call 303-602-1590 to make an appointment.

Knee replacement involves replacing a knee joint that has been damaged or worn away, usually by arthritis or injury. Find out more here: https://www.bupa.co.uk/health-....information/knee-cli

This surgical procedure helps children defeat bone cancer.

Watch that video of Unbelievable Mutations and Medical Condition Photos

Anatomy of The Peritoneal Cavity

Dizziness is a word that is often used to describe two different feelings. It is important to know exactly what you mean when you say "I feel dizzy," because it can help you and your doctor narrow down the list of possible problems. Lightheadedness is a feeling that you are about to faint or "pass out." Although you may feel dizzy, you do not feel as though you or your surroundings are moving. Lightheadedness often goes away or improves when you lie down. If lightheadedness gets worse, it can lead to a feeling of almost fainting or a fainting spell (syncope). You may sometimes feel nauseated or vomit when you are lightheaded. Vertigo is a feeling that you or your surroundings are moving when there is no actual movement. You may feel as though you are off balance, spinning, whirling, falling, or tilting. When you have severe vertigo, you may feel very nauseated or vomit. You may have trouble walking or standing, and you may lose your balance and fall.

Expand Section. Pulmonary edema is often caused by congestive heart failure. When the heart is not able to pump efficiently, blood can back up into the veins that take blood through the lungs. As the pressure in these blood vessels increases, fluid is pushed into the air spaces (alveoli) in the lungs.