Ca2+ binds with the membrane of the synaptic vesicles, which causes the vesicles to break and release the neurotransmitter into the synaptic cleft. After the neurotransmitters are released, they diffuse across the synaptic cleft and interact with receptors on the postsynaptic membrane. When the action potential reaches the presynaptic terminal, it provokes the release of a small quantity of neurotransmitter molecules, which bind to chemical receptor molecules located in the membrane of another neuron, the postsynaptic neuron, on the opposite side of the synaptic cleft.

How revolutionizing advancements helps patients with metastatic melanoma kick start the body’s immune system to increase survival.

How to approach histology for Human Anatomy students. Using a key will help get you through it! Add some penguin fairy dust will help too!

Please note: I mis-spoke and said "striated" instead of "stratified epithelium" a couple of times... apologies!

There are lots of histology keys out there, but the one I showed in the video is here: http://www.penguinprof.com/upl....oads/8/4/3/1/8431323

Want more?
Subscribe: http://www.youtube.com/user/ThePenguinProf
FB Page: https://www.facebook.com/ThePenguinProf
Twitter: https://twitter.com/penguinprof
Web: http://www.penguinprof.com/


---------------------------------------------------------------------------------------------------
Details:

Tissue in the human body:

Epithelial: Is made of cells arranged in a continuous sheet with one or more layers, has apical & basal surfaces.

A basement membrane is the attachment between the basal surface of the cell & the underlying connective tissue.

Two types of epithelial tissues: (1) Covering & lining epithelia and (2) Glandular Epithelium.

The number of cell layers & the shape of the cells in the top layer can classify epithelium.

Simple Epithelium - one cell layer
Stratified epithelium - two or more cell layers
Pseudostratified Columnar Epithelium - When cells of an epithelial tissue are all anchored to the basement Membrane but not all cells reach the apical surface.
Glandular Epithelium -- (1) Endocrine: Release hormones directly into the blood stream and (2) Exocrine - Secrete into ducts.


Connective: contains many different cell types including: fibroblasts, macrophages, mast cells, and adipocytes. Connective Tissue Matrix is made of two materials: ground substance - proteins and polysaccharides, fiber -- reticular, collagen and elastic.

Classification of Connective Tissue:
Loose Connective - fibers & many cell types in gelatinous matrix, found in skin, & surrounding blood vessels, nerves, and organs.
Dense Connective - Bundles of parallel collagen fibers& fibroblasts, found in tendons& ligaments.
Cartilage - Cartilage is made of collagen & elastin fibers embedded in a matrix glycoprotein & cells called chondrocytes, which was found in small spaces.
Cartilage has three subtypes:
Hyaline cartilage -- Weakest, most abundant type, Found at end of long bones, & structures like the ear and nose,
Elastic cartilage- maintains shape, branching elastic fibers distinguish it from hyaline and
Fibrous Cartilage - Strongest type, has dense collagen & little matrix, found in pelvis, skull & vertebral discs.


Muscle: is divided into 3 categories, skeletal, cardiac and smooth.
Skeletal Muscle -- voluntary, striated, striations perpendicular to the muscle fibers and it is mainly found attached to bones.
Cardiac Muscle -- involuntary, striated, branched and has intercalated discs
Smooth Muscle -- involuntary, nonstriated, spindle shaped and is found in blood vessels & the GI tract.


Nervous: Consists of only two cell types in the central nervous system (CNS) & peripheral nervous system (PNS):
Neurons - Cells that convert stimuli into electrical impulses to the brain, and Neuroglia -- supportive cells.
Neurons -- are made up of cell body, axon and dendrites. There are 3 types of neurons:
Motor Neuron -- carry impulses from CNS to muscles and glands,
Interneuron - interpret input from sensory neurons and end responses to motor neurons
Sensory Neuron -- receive information from environment and transmit to CNS.
Neuroglia -- is made up of astrocytes, oligodendrocytes, ependymal cells and microglia in the CNS, and schwann cells and satellite cells in the PNS.

Dr. Arthur Handal explains the differences patients can expect when their surgeon chooses to use either a needle or a cannula to inject facial fillers.

Red eyes usually are caused by allergy, eye fatigue, over-wearing contact lenses or common eye infections such as pink eye (conjunctivitis). However, redness of the eye sometimes can signal a more serious eye condition or disease, such as uveitis or glaucoma.

Menstrual cramps (dysmenorrhea) are throbbing or cramping pains in the lower abdomen. ... Menstrual cramps may be caused by identifiable problems, such as endometriosis or uterine fibroids. Treating any underlying cause is key to reducing the pain

IV cannulation is a skill that has scared a lot of student nurses and even professionals. Perhaps it’s because IV insertion is an invasive procedure, and nurses are too worried that they might hurt their patients. Or maybe it’s because they are just clueless about IV therapy do’s and don’ts–things that one can only fully understand through constant practice.

The da Vinci® Surgical System provides surgeons with an alternative to both traditional open surgery and conventional laparoscopy, putting a surgeon's hands at the controls of a state-of-the-art robotic platform. Our surgeons can perform even the most complex and delicate procedures through very small incisions with unmatched precision.

Symptoms of depression in women include: Persistent sad, anxious, or "empty" mood. Loss of interest or pleasure in activities, including sex. Restlessness, irritability, or excessive crying. Feelings of guilt, worthlessness, helplessness, hopelessness, pessimism. Sleeping too much or too little, early-morning awakening.

A pancreas transplant is a surgical procedure to place a healthy pancreas from a deceased donor into a person whose pancreas no longer functions properly. Your pancreas is an organ that lies behind the lower part of your stomach. One of its main functions is to make insulin, a hormone that regulates the absorption of sugar (glucose) into your cells. If your pancreas doesn't make enough insulin, blood sugar levels can rise to unhealthy levels, resulting in type 1 diabetes. Most pancreas transplants are done to treat type 1 diabetes. A pancreas transplant offers a potential cure for this condition. But it is typically reserved for those with serious diabetes complications, because the side effects of a pancreas transplant are significant. In some cases, pancreas transplants may also treat type 2 diabetes. Rarely, pancreas transplants may be used in the treatment of pancreatic, bile duct or other cancers. A pancreas transplant is often done in conjunction with a kidney transplant in people whose kidneys have been

The term subclavian steal describes retrograde blood flow in the vertebral artery associated with proximal ipsilateral subclavian artery stenosis or occlusion, usually in the setting of subclavian artery occlusion or stenosis proximal to the origin of the vertebral artery. Alternatively, innominate artery disease has also been associated with retrograde flow in the ipsilateral vertebral artery, particularly where the subclavian artery origin is involved. Subclavian steal is frequently asymptomatic and may be discovered incidentally on ultrasound or angiographic examination for other indications, or it may be prompted by a clinical examination finding of reduced unilateral upper limb pulse or blood pressure. In some cases, patients may develop upper limb ischemic symptoms due to reduced arterial flow in the setting of subclavian artery occlusion, or they may develop neurologic symptoms due to posterior circulation ischemia associated with exercise of the ipsilateral arm.[1] Treatment has traditionally consisted of open subclavian artery revascularization, typically via carotid-subclavian bypass or subclavian artery transposition, which are generally durable procedures. Newer, less invasive options include endovascular intervention with recanalization as appropriate and angioplasty and stenting if required. The clinical relevance of subclavian steal was described in 1961 by Reivich, Holling and Roberts; however, the recognition of retrograde vertebral artery flow dates back another 100 years to Harrison and Smyth. Some papers, including a previous version of this article, advocate restricting the term subclavian steal to patients with neurologic symptoms only, but this is incorrect in view of the substantial literature using this term to describe the hemodynamic scenario of retrograde vertebral flow and proximal subclavian artery disease.

Cervical cancer occurs when abnormal cells on the cervix camera.gif grow out of control. The cervix is the lower part of the uterus that opens into the vagina. Cervical cancer can often be successfully treated when it's found early. It is usually found at a very early stage through a Pap test.

Watch that Ectopic Baby Medical Abortion Surgery

Care for Your Knee After Knee Replacement Surgery
In this video, Dr. Mark Hammerberg, provides details on two important activities to help during recovery from knee replacement surgery.

Denver Health's Orthopedics department offers many different types of treatments to help you, including surgical and non-surgical options. To find out if surgery is right for you, visit DenverHealth.org/Orthopedics or call 303-602-1590 to make an appointment.

Overweight does not necessarily equal unhealthy. There are actually plenty of overweight people who are in excellent health (1). Conversely, many normal weight people have the metabolic problems associated with obesity (2). That’s because the fat under the skin is actually not that big of a problem (at least not from a health standpoint, it’s more of a cosmetic problem). It’s the fat in the abdominal cavity, the belly fat, that causes the biggest issues (3). If you have a lot of excess fat around your waistline, even if you’re not very heavy, then you should take some steps to get rid of it. Belly fat is usually estimated by measuring the circumference around your waist. This can easily be done at home with a simple tape measure. Anything above 40 inches (102 cm) in men and 35 inches (88 cm) in women, is known as abdominal obesity. There are actually a few proven strategies that have been shown to target the fat in the belly area more than other areas of the body.

James Slover, MD, and Ivan Madrid, MD, describe the benefits of knee replacement surgery, the differences in partial and total knee replacement, and how the procedures are performed at NYU Langone.

Learn more about Dr. Slover: http://nyulangone.org/doctors/....1851355564/james-d-s

Learn more about Dr. Madrid: http://nyulangone.org/doctors/....1912940107/ivan-madr

To learn more about joint replacement surgery at NYU Langone, visit: http://nyulangone.org/location....s/center-for-musculo

How Bone Fractures Are Repaired

Tracheal Deviation Technique

Septoplasty (SEP-toe-plas-tee) is a surgical procedure to correct a deviated septum — a displacement of the bone and cartilage that divides your two nostrils. During septoplasty, your nasal septum is straightened and repositioned in the middle of your nose.