Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target guanines. Cisplatin can bond more tightly with nitrogen because nitrogen balances the platinum charge more effectively than chlorine. It is this adduct-induced DNA bend that allows binding of proteins which contain the high mobility group, HMG domain. Once the protein is bound to the DNA, it inserts a wedge-like phenyl group of phenylalanine 37 into the widened minor groove created by the bend. The tightly bound HMG protein causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, Cisplatin can be thought of as a monkey wrench in the DNA repair system. With the HMG protein bound to the DNA, the modified strand is not repaired properly and so the cell dies. The success of Cisplatin depends on its ratio of efficacy between cancerous and healthy cells.

This video, Rheumatoid arthritis is a chronic inflammatory disorder that can affect more than just your joints. In some people, the condition also can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels. An autoimmune disorder, rheumatoid arthritis occurs when your immune system mistakenly attacks your own body's tissues. Unlike the wear-and-tear damage of osteoarthritis, rheumatoid arthritis affects the lining of your joints, causing a painful swelling that can eventually result in bone erosion and joint deformity. The inflammation associated with rheumatoid arthritis is what can damage other parts of the body as well. While new types of medications have improved treatment options dramatically, severe rheumatoid arthritis can still cause physical disabilities.

MUSC Children’s Health offers South Carolina’s only Level 1 Children’s Surgery Center, representing excellence in inpatient surgery at MUSC Shawn Jenkins Children’s Hospital, as well as outpatient surgery at R. Keith Summey Medical Pavilion. These two state-of-the-art facilities are equipped with a team of pediatric board-certified providers utilizing pediatric-specific devices and the most technologically advanced tools.

Antisocial personality disorder (ASPD) is defined by the American Psychiatric Association's Axis II (personality disorders) of the Diagnostic and Statistical Manual (DSM-IV-TR) as "a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood." Antisocial personality disorder is sometimes wrongly referred to as psychopathy or sociopathy. Currently, neither psychopathy nor sociopathy are valid diagnoses described in the Diagnostic and Statistical Manual of Mental Disorders, and the ICD-10 of the World Health Organization also lacks psychopathy as a diagnostic disorder. Psychopathy is normally seen as a subset of the antisocial personality disorder, but Blair believes that the antisocial personality disorder and psychopathy may be separate conditions altogether.

A ventricular septal defect (VSD), a hole in the heart, is a common heart defect that's present at birth (congenital). The hole occurs in the wall that separates the heart's lower chambers (septum) and allows blood to pass from the left to the right side of the heart. The oxygen-rich blood then gets pumped back to the lungs instead of out to the body, causing the heart to work harder. A small ventricular septal defect may cause no problems, and many small VSDs close on their own. Larger VSDs need surgical repair early in life to prevent complications.

TV interview with Dr. Mostafa Yakoot, MD discussing latest researches on herbal drugs

Ventricular fibrillation is a heart rhythm problem that occurs when the heart beats with rapid, erratic electrical impulses. This causes pumping chambers in your heart (the ventricles) to quiver uselessly, instead of pumping blood. Sometimes triggered by a heart attack, ventricular fibrillation causes your blood pressure to plummet, cutting off blood supply to your vital organs. Ventricular fibrillation, an emergency that requires immediate medical attention, causes the person to collapse within seconds. It's the most frequent cause of sudden cardiac death. Emergency treatment includes cardiopulmonary resuscitation (CPR) and shocks to the heart with a device called a defibrillator. Treatments for those at risk of ventricular fibrillation include medications and implantable devices that can restore a normal heart rhythm.

Mommy Makeover plastic surgery in NYC and is a fairly new phenomena. This video, from 5thavenue surgery; http://www.5thavesurgery.com, goes through a case study of a patient getting plastic surgery in NYC. Check out what a Mommy Makeover can do for your body and what Plastic Surgery can do for you.

Force Does It Take To Break A Bone

A good starting point for any scientist in any field is to recognize that there is much we do not know. We do not know, for example, why there is more matter than antimatter in the universe. We do not know very well how the evolution of the dinosaurs filtered out. And, perhaps most surprising of all is that we do not know very well how many organs the human body has or what all its functions are.

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Medical device manufacturers need to find new and innovative ways to explain their products to potential buyers.

It can be difficult for potential buyers to understand how a medical device works, and even more difficult to visualize how it would be used in a clinical setting.

Medical animation videos are the perfect way to showcase your medical devices.

They are engaging, easy to understand, and help potential buyers see how your product would fit into their workflow.

Jump to the video you like:
8. Pharming Healthcare 0:09
7. ThermoFisher Scientific 2:46
6. Fibrogen 5:49
5. OrthAlign 9:29
4. Edwards LifeSciences 11:34
3. Edwards LifeSciences 12:51
2. Edwards LifeSciences 13:43
1. Edwards LifeSciences 18:14

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2. Healthcare Product Explainer Video for Edwards Lifesciences: https://on.b2w.tv/3OSdMDb
3. Healthcare Commercial Video for Coopervision: https://on.b2w.tv/45muvpf
4. Healthcare Marketing Video for OrthAlign: https://on.b2w.tv/3P8KBgD
5. Healthcare Video Marketing with The Video-First Approach: https://on.b2w.tv/3LiNDfW
6. 12 Best Brand Archetypes for Healthcare Videos: https://on.b2w.tv/3EIQ0Vu

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2. 5 Animated Healthcare Commercial Videos: https://on.b2w.tv/47IgpAd
3. 11 Animated Healthcare Explainer Videos: https://on.b2w.tv/3Zd7fYM
4. How Long Does It Take To Make an Healthcare Explainer Video: https://on.b2w.tv/45nasak
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A very simplified method giving information about cystic fibrosis

Colon - Polypectomy, Saline lift, Adenomas

Labyrinthitis is a mild, often self-limited condition characterized by vertigo, tinnitus, nausea, and a loss of balance. The disorder often follows a viral illness (eg, influenza). Labyrinthitis may also be caused by trauma, bacterial infection, allergies, benign tumors, and certain medications .

Progressive multifocalleukoencephalopathy is a demyelinating illness of the central nervous system that typically occurs in immunosuppressed patients, especially those with AIDS. It is caused by reactivation of the polyomavirus JC (JC virus) and presents with neurologic deficits including hemiparesis, gait ataxia, visual symptoms, and altered mental status. It is not seen in non-immunosuppressed patients, and fever is not typical

Prompt treatment to break up the clot greatly reduces the risk of death. This can be done with blood thinners and drugs or procedures. Compression stockings and physical activity can help prevent clots from forming in the first place.

An estimated 12,500 spinal cord injuries occur in the U.S. every year, leaving the injured people, their friends, and their family, to cope with the aftermath of the catastrophe. For many, navigating the challenges of the health care system can feel a bit like going to medical school. Suddenly you're learning a veritable cornucopia of new terms, and may be spending endless hours Googling spinal cord anatomy to fill in the gaps in your knowledge. An educated patient is better equipped to advocate for his or her needs and interests. An education in spinal cord anatomy helps you understand what your doctor is saying, ask intelligent questions, and detect medical errors before they endanger your health.

دكتور مصطفى ياقوت فى حوار على القناة الفضائية المصرية عن الطب البديل و الطب الفرعونى فى علاج الأرق
TV interview with Dr. Mostafa Yakoot about Alternative medicine

Acute kidney injury is common entity in medical practice. The present definition is based on a serum creatinine rise of more 0.3 mg/dl in 48 hours or less, a 50% increase from the baseline over a period of 07 days or a urine output of less than 0.5 ml/kg/hour for more than 06 hours. The main causes of acute kidney injury may be classified into pre renal, intrinsic or post renal causes. Rapid diagnosis and prompt treatment is essential to prevent mortality or morbidity. This presentation discusses in detail the causes of all three mechanisms, pre-renal, post renal and intrinsic.

Dr. Leo Maguire, a Mayo Clinic ophthalmologist, explains how laser-assisted in situ keratomileusis (LASIK) eye surgery can correct common vision problems.

This interview originally aired Jan. 26, 2019.

To learn more about LASIK surgery, visit: https://www.mayoclinic.org/tests-procedures/lasik-eye-surgery/about/pac-20384774?mc_id=us&utm_source=newsnetwork&utm_medium=l&utm_content=content&utm_campaign=mayoclinic&geo=national&placementsite=enterprise&cauid=100721&_ga=2.112234244.1227307149.1547427243-1780934405.1469629163