If you’re considering an epidural to help manage the pain of childbirth, you’re not alone. More than 60 percent of women delivering at hospitals elect for an epidural during labor. And with good reason: An epidural is considered one of the safest methods of pain control, with just one in 3,000 pregnancies experiencing serious complications. It’s also good for you, since you’ll remain awake and alert during the birth, as well as for your baby, since the drugs will barely reach your bloodstream (so they can’t get into hers).

Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target guanines. Cisplatin can bond more tightly with nitrogen because nitrogen balances the platinum charge more effectively than chlorine. It is this adduct-induced DNA bend that allows binding of proteins which contain the high mobility group, HMG domain. Once the protein is bound to the DNA, it inserts a wedge-like phenyl group of phenylalanine 37 into the widened minor groove created by the bend. The tightly bound HMG protein causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, Cisplatin can be thought of as a monkey wrench in the DNA repair system. With the HMG protein bound to the DNA, the modified strand is not repaired properly and so the cell dies. The success of Cisplatin depends on its ratio of efficacy between cancerous and healthy cells.

This video shows the heart transplant surgery

HYSTERECTOMY RECOVERY: ALL PROCEDURES ARE NOT CREATED EQUAL Too often, women are only given the option of an open hysterectomy for conditions like large fibroids or an enlarged uterus. Surgical techniques have evolved in the last decade, but across the United States, the number of women still having open hysterectomy procedures is unnecessarily staggering. Robotic procedures are becoming more common as hospitals invest nearly $2 million in the machine. While the robot does allow surgeons who are not necessarily trained in laparoscopic procedures to perform a more minimally invasive surgery, tools cannot replace skill. There is no added benefit to the patient and the surgery can cost on average up to $2,000 more than other laparoscopic options, and in some cases much higher.

Colon - Polypectomy, Saline lift, Adenomas

TV interview with Dr. Mostafa Yakoot, MD discussing latest researches on herbal drugs

According to a Danish study , frequent sex may help prevent pre-eclampsia. Researchers believe it's because of a protein found in sperm that can regulate the body's immune system. Yet because the cause of preeclampsia is unknown, it's important to keep your prenatal visits and talk to your doctor about your risk.

1. What is hemodialysis?
2. Why do you do hemodialysis?
3. How does hemodialysis remove body waste?
4. What are the symptoms and side effects of hemodialysis?
5. How should I eat food when I do hemodialysis?
6. What are some precautions for patients during hemodialysis?


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A laparoscope is a small, thin tube that is put into your body through a tiny cut made just below your navel. Your surgeon can then see your gallbladder on a television screen and do the surgery with tools inserted in three other small cuts made in the right upper part of your abdomen. Your gallbladder is then taken out through one of the incisions.

Neglected elbow dislocations are seen in patients hailing from Africa and Asia. A Nigerian patient with this condition was successfully treated by open reduction and external fixator application

If you’re like me, you probably hook your chest tube up to a Pleur-Evac, put it on the ground, then back away slowly. Who knows what goes on in that mysterious bubbling white box? Hopefully this will post shed some light. Isn’t this just a container for stuff that comes out of the chest? Why does it look so complicated? It’s complicated because the detection/collection of air and fluid require different setups. Most commercial models also allow you to hook the drainage system to wall suction, so you can quickly evacuate the pleural space. This requires its own setup. Because of the need to juggle air, fluid and suction, the most common commercial system includes 3 distinct chambers. If you were to simplify the device, or build one out of spare bottles and tubes, it might look like this:

The heart weighs between 7 and 15 ounces (200 to 425 grams) and is a little larger than the size of your fist. By the end of a long life, a person's heart may have beat (expanded and contracted) more than 3.5 billion times. In fact, each day, the average heart beats 100,000 times, pumping about 2,000 gallons. Your heart is located between your lungs in the middle of your chest, behind and slightly to the left of your breastbone (sternum). A double-layered membrane called the pericardium surrounds your heart like a sac. The outer layer of the pericardium surrounds the roots of your heart's major blood vessels and is attached by ligaments to your spinal column, diaphragm, and other parts of your body. The inner layer of the pericardium is attached to the heart muscle. A coating of fluid separates the two layers of membrane, letting the heart move as it beats. Your heart has 4 chambers. The upper chambers are called the left and right atria, and the lower chambers are called the left and right ventricles. A wall of muscle called the septum separates the left and right atria and the left and right ventricles. The left ventricle is the largest and strongest chamber in your heart. The left ventricle's chamber walls are only about a half-inch thick, but they have enough force to push blood through the aortic valve and into your body.

Can a Vaccine Give Me the Disease It’s Supposed to Protect Me Against?

⁣Endovascular Coiling of Unruptured Ophthalmic Artery Aneurysm

For open hernia repair surgery, a single long incision is made in the groin. If the hernia is bulging out of the abdominal wall (a direct hernia), the bulge is pushed back into place. If the hernia is going down the inguinal canal (indirect), the hernia sac is either pushed back or tied off and removed.

A positive Speed's test result is usually thought to suggest inflammation or lesions related to the biceps/labral complex. The specificity, sensitivity, and positive and negative predictive values are determined for the Speed's test.

Pediatric Surgery Day Unit (PSDU)
Welcome to Harley Street state-of-the-art Pediatric Surgery Day Unit! We are thrilled to have the opportunity to provide exceptional care and support for our young patients and their families. At our unit, we understand the unique needs and concerns associated with pediatric surgery, and we strive to create a safe and comforting environment for everyone involved.

Compassionate Care by Dedicated Professionals
Lead by Consultant Pediatric Surgeon, Dr. Niall Martin Jones, we will ensure your baby is looked after to the highest possible standards. Our dedicated team and support staff is committed to delivering the highest quality of care. All procedures are performed with local anesthetic and sucrose for comfort. Usually, your baby is so comfortable that she/he will be asleep by the end of the treatment.

Advanced Technology and Safety Measures
Patient safety is our utmost priority. We have implemented rigorous infection control measures to ensure a sterile environment. Our operating rooms are equipped with advanced technology and monitoring systems to ensure the highest standards of safety and precision during surgery. Our anesthesiologists are experienced in administering anesthesia to children, ensuring a smooth and comfortable experience.

learn more https://www.hsmc.ae/our-clinic....s/pediatric-surgery-
#pediatricsurgery #pediatrics #childhealthcare

Chronic angina is a prevalent manifestation of cardiovascular disease and is most commonly due to insufficient oxygen supply from fixed epicardial lesions in the coronary arteries.

Preventing Perineal Tears HD