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Usually a sebaceous cyst grows very slowly and doesn't cause pain. However, they can become inflamed or infected, with the overlying skin becoming red, tender, and sore. Sometimes, they occur on a site that is constantly irritated, such as a cyst on your neck that rubs against your collar.
Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is a chronic liver disease resulting from progressive destruction of the bile ducts in the liver – called the intrahepatic bile ducts. Bile produced in your liver travels via these ducts to your small intestine where it aids in the digestion of fat and fat-soluble vitamins (A, D, E and K). When the ducts are destroyed, bile builds up in the liver contributing to inflammation and scarring (fibrosis). Eventually this can lead to cirrhosis and its associated complications, as scar tissue replaces healthy liver tissue and liver function becomes increasingly impaired.