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Ascending Sensory Pathways
Ascending Sensory Pathways Doctor 8,930 Views • 3 years ago

A tutorial showing ascending sensory pathways

Cell Organelles in 3D
Cell Organelles in 3D DrPhil 8,928 Views • 3 years ago

Cell Organelles in 3D

Part 2: Translational Neuroscience of Excessive Daytime Sleepiness (EDS), Fatigue and Hype
Part 2: Translational Neuroscience of Excessive Daytime Sleepiness (EDS), Fatigue and Hype Mohammad Torabi Nami 8,926 Views • 3 years ago

Sleepiness, tiredness and fatigue are complaints which must be thoroughly analyzed to eliminate blur and ambiguity.
Physiological sleepiness (“sleep pressure”) increases while being awake and additionally underlies the circadian rhythm with a lower threshold to fall asleep during night time.
Excessive daytime sleepiness (EDS) is considered normal only after sleep deprivation. Clinically, EDS manifests by frequents daytime napping and/or reduced alertness with automatic behavior or - in its extreme form - in recurrent attacks of sudden, uncontrollable compulsion to sleep also in inappropriate situations (= “sleep attacks”).
EDS is “objectively” addressed by measuring the mean sleep latency to four to five nap opportunities throughout the day using the multiple sleep latency test (MSLT) or the maintenance of wakefulness test (MWT).
EDS denotes both, a ready entrance into sleep as well as difficulty in staying awake during daytime or accordingly in inappropriate situations. These two partially independent aspects of EDS are separately assessed by the “passive” MSLT and the “active” MWT respectively.
For that reason the MSLT and MWT only weakly correlate with each other when tested over a broad range of patients with EDS. It is important to keep in mind, that these tests are importantly influenced by a great variety of factors such as mood, anxiety, and motivation.
“Vigilance” comprises wakefulness, alertness and attention and therefore is more than just the reciprocal to sleepiness. Cognitive performance tasks such as Steer Clear Reaction Time Test (SCRTT) or driving simulators require the complete integrity of vigilance to achieve normal results. Hypersomnia is usually broadly defined as the combination of abnormally prolonged night-time sleep (regularly >10 h) with EDS during ≥1 months.
On the other hand, the term hypersomnia has also been used in a narrower scene for the isolated abnormality of a prolonged night-time sleep need (>10 h). “Tiredness”, also in colloquial language often used for sleepiness, in a broader sense also describes the feeling of lack of energy, motivation and initiative.

These patients seek rest rather than sleep. They often cannot fall asleep when given the opportunity in spite of feeling tired, and hence, in an MSLT, do not show an abnormally short sleep latency. Furthermore, tiredness (and fatigue) as opposed to sleepiness has a mental (“central”) and physiological (bodily or “peripheral”) component, which the patients can readily distinguish. Patients with insomnia, mild sleep apnea syndrome, or depression rather suffer from mental tiredness than sleepiness during the day.
The simple subjective self-assessment using the Epworth Sleepiness Scale (ESS) quite reliably differentiates between sleepiness and mental tiredness (without sleepiness), which makes it a widely used test. The term “fatigue” is also heterogeneously used.
In physiology the “fatigue” implied a “time on task performance decrement” to describe decreasing muscle force during a sustained physical effort. In clinical medicine one distinguishes physical (“peripheral”) from mental (“central”) fatigue and the term usually denotes a chronic and more abnormal situation than tiredness.
In a broad sense “fatigue” implies a deficiency in coping satisfactorily with mental and physical work load. The chronic fatigue syndrome entails both mental as well as a physical fatigue (so called “leaden paralysis” of limbs). Depressive states are often associated with insomnia and fatigue, but there are also cases with hypersomnia rather than insomnia ( non organic hypersomnia , “atypical depression” or “hypersomnolent depression”)
Sometimes these patients have a tendency to spend much of the day lying in the bed without actually sleeping (so called clinophilia). The basic and clinical aspects of fatigu

HIV Prevention in Africa
HIV Prevention in Africa Liz L 8,914 Views • 3 years ago

Doctor Amneris Luque talks about HIV Prevention in Africa. STDdatings .com was created to help people to learn HIV / AIDS prevention, share medical treatments, find trusted people to talk, get help and advice.

Anti Aging Diet
Anti Aging Diet Alicia Berger 8,910 Views • 3 years ago

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Gall bladder Stone Removed
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Your body needs bile, but if it has too much cholesterol in it, that makes gallstones more likely. It can also happen if your gallbladder can't empty properly. Pigment stones are more common in people with certain medical conditions, such as cirrhosis (a liver disease) or blood diseases such as sickle cell anemia.

How to do an Insulin Injection
How to do an Insulin Injection samer kareem 8,909 Views • 3 years ago

Insert the needle into the rubber stopper of the insulin bottle. Push the plunger down to inject air into the bottle (this allows the insulin to be drawn more easily). Leave the needle in the bottle. Turn the bottle and syringe upside-down.

Scaphoid Fracture Screw Fixation
Scaphoid Fracture Screw Fixation samer kareem 8,907 Views • 3 years ago

An animated description of the use of a cannulated Herbert screw for surgical treatment of scaphoid fractures.

New Drugs Improve Osteoporosis Treatment
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Preparing Kidney for Transplant
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Laparoscopic inguinal hernia repair
Laparoscopic inguinal hernia repair mohamed al emadi 8,902 Views • 3 years ago

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Baby Kicks during Pregnancy
Baby Kicks during Pregnancy samer kareem 8,900 Views • 3 years ago

Are you a first time would be mom? If yes, then you must be very excited to feel the first movement and kick from your baby. It is undoubtedly the most exciting experience for many expecting moms. It is an indication that there is a little angel growing inside you. There are interesting facts about baby kicks during pregnancy that you need to know.

Injecting Insulin Techniques
Injecting Insulin Techniques Harvard_Student 8,899 Views • 3 years ago

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Phlebotomy Steps
Phlebotomy Steps M_Nabil 8,898 Views • 3 years ago

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The sun and your skin
The sun and your skin News Canada 8,897 Views • 3 years ago

Skin cancer is the most common of all cancer types, accounting for an estimated one third of all new cases. It’s important to take the right steps to ensure proper protection and adopt good sun care habits no matter what your age or stage in life.

fingerprints and sweat glands
fingerprints and sweat glands samer kareem 8,894 Views • 3 years ago

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H1N1 Flu and Antiviral Drugs
H1N1 Flu and Antiviral Drugs Doctor 8,881 Views • 3 years ago

This podcast discusses the use of antiviral drugs for treating and preventing the H1N1 flu virus.

Sectioned Heart
Sectioned Heart samer kareem 8,876 Views • 3 years ago

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Austin Tummy Tuck Surgeons
Austin Tummy Tuck Surgeons Tuesday Wilson 8,866 Views • 3 years ago

Shannon, who recently underwent gastric bypass surgery, discusses her hopes and aspirations for life after her upcoming abdominoplasty surgery in Austin. Abdominoplasty, more commonly known as tummy tuck surgery, is a procedure which removes excess skin from the midsection and tightens the abdominal muscles for a more sculpted, leaner appearance. Please visit http://www.personique.com/tummy-tuckabdominoplasty.php to learn more about abdominoplasty in Austin.

Histology of Bone Marrow Smear
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