Top videos

Mechanism of Cisplatin Anti-Cancer Drug
Mechanism of Cisplatin Anti-Cancer Drug Scott Stevens 16,996 Views • 3 years ago

Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target guanines. Cisplatin can bond more tightly with nitrogen because nitrogen balances the platinum charge more effectively than chlorine. It is this adduct-induced DNA bend that allows binding of proteins which contain the high mobility group, HMG domain. Once the protein is bound to the DNA, it inserts a wedge-like phenyl group of phenylalanine 37 into the widened minor groove created by the bend. The tightly bound HMG protein causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, Cisplatin can be thought of as a monkey wrench in the DNA repair system. With the HMG protein bound to the DNA, the modified strand is not repaired properly and so the cell dies. The success of Cisplatin depends on its ratio of efficacy between cancerous and healthy cells.

First Aid: Snake Bite
First Aid: Snake Bite samer kareem 3,409 Views • 3 years ago

Move the person beyond striking distance of the snake. Have the person lie down with wound below the heart. Keep the person calm and at rest, remaining as still as possible to keep venom from spreading. Cover the wound with loose, sterile bandage

USMLE Step 2 CS - Diabetes Mellitus
USMLE Step 2 CS - Diabetes Mellitus usmle tutoring 10,350 Views • 3 years ago

USMLE Step 2 CS - Diabetes Mellitus This is just preview video. To get full access please visit our website : www.usmletutoring.com

Loyola Neonatal Exam Part 1
Loyola Neonatal Exam Part 1 Loyola Medicine 22,211 Views • 3 years ago

A video from Loyola medical school, Chicago showing full neonatal medical examination Part 1

Inside Al Roker’s Road To Recovery After Knee Replacement | TODAY
Inside Al Roker’s Road To Recovery After Knee Replacement | TODAY Surgeon 119 Views • 3 years ago

TODAY’s Al Roker is back at work, less than two weeks after knee replacement surgery. Al reveals the rigorous course of physical therapy that helped get him back on his feet so quickly. He says the procedure has improved radically since his first knee replacement 15 years ago.
» Subscribe to TODAY: http://on.today.com/SubscribeToTODAY
» Watch the latest from TODAY: http://bit.ly/LatestTODAY

About: TODAY brings you the latest headlines and expert tips on money, health and parenting. We wake up every morning to give you and your family all you need to start your day. If it matters to you, it matters to us. We are in the people business. Subscribe to our channel for exclusive TODAY archival footage & our original web series.

Connect with TODAY Online!
Visit TODAY's Website: http://on.today.com/ReadTODAY
Find TODAY on Facebook: http://on.today.com/LikeTODAY
Follow TODAY on Twitter: http://on.today.com/FollowTODAY
Follow TODAY on Google+: http://on.today.com/PlusTODAY
Follow TODAY on Instagram: http://on.today.com/InstaTODAY
Follow TODAY on Pinterest: http://on.today.com/PinTODAY

Inside Al Roker’s Road To Recovery After Knee Replacement | TODAY

How to Heal Throat Ulcers From Acid Reflux
How to Heal Throat Ulcers From Acid Reflux samer kareem 4,087 Views • 3 years ago

10 Facts About ORGASMS
10 Facts About ORGASMS samer kareem 9,113 Views • 3 years ago

An orgasm is a feeling of intense sexual pleasure that happens during sexual activity. It's sometimes called "coming" or "climaxing". Both men and women have orgasms.

Rheumatoid Arthritis Treatment
Rheumatoid Arthritis Treatment samer kareem 2,020 Views • 3 years ago

This video, Rheumatoid arthritis is a chronic inflammatory disorder that can affect more than just your joints. In some people, the condition also can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels. An autoimmune disorder, rheumatoid arthritis occurs when your immune system mistakenly attacks your own body's tissues. Unlike the wear-and-tear damage of osteoarthritis, rheumatoid arthritis affects the lining of your joints, causing a painful swelling that can eventually result in bone erosion and joint deformity. The inflammation associated with rheumatoid arthritis is what can damage other parts of the body as well. While new types of medications have improved treatment options dramatically, severe rheumatoid arthritis can still cause physical disabilities.

Patty Jackson WDAS  Interviews Co-Founders of The Fibroids Project (FibroidsProject.com)
Patty Jackson WDAS Interviews Co-Founders of The Fibroids Project (FibroidsProject.com) Nimmy Sagar 6,998 Views • 3 years ago

Patty Jackson WDAS Interviews Renee Brown & Nnamdi G. Osuagwu, Co-Founders of The Fibroids Project (FibroidsProject.com).

Early Signs that Cancer is Growing in Your Body
Early Signs that Cancer is Growing in Your Body samer kareem 19,525 Views • 3 years ago

Early Signs that Cancer is Growing in Your Body

Your baby is in safe hands with Dr. Niall Jones Pediatric Surgeon
Your baby is in safe hands with Dr. Niall Jones Pediatric Surgeon Surgeon 91 Views • 3 years ago

Pediatric Surgery Day Unit (PSDU)
Welcome to Harley Street state-of-the-art Pediatric Surgery Day Unit! We are thrilled to have the opportunity to provide exceptional care and support for our young patients and their families. At our unit, we understand the unique needs and concerns associated with pediatric surgery, and we strive to create a safe and comforting environment for everyone involved.

Compassionate Care by Dedicated Professionals
Lead by Consultant Pediatric Surgeon, Dr. Niall Martin Jones, we will ensure your baby is looked after to the highest possible standards. Our dedicated team and support staff is committed to delivering the highest quality of care. All procedures are performed with local anesthetic and sucrose for comfort. Usually, your baby is so comfortable that she/he will be asleep by the end of the treatment.

Advanced Technology and Safety Measures
Patient safety is our utmost priority. We have implemented rigorous infection control measures to ensure a sterile environment. Our operating rooms are equipped with advanced technology and monitoring systems to ensure the highest standards of safety and precision during surgery. Our anesthesiologists are experienced in administering anesthesia to children, ensuring a smooth and comfortable experience.

learn more https://www.hsmc.ae/our-clinic....s/pediatric-surgery-
#pediatricsurgery #pediatrics #childhealthcare

Chest Tube Drainage System
Chest Tube Drainage System samer kareem 3,380 Views • 3 years ago

If you’re like me, you probably hook your chest tube up to a Pleur-Evac, put it on the ground, then back away slowly. Who knows what goes on in that mysterious bubbling white box? Hopefully this will post shed some light. Isn’t this just a container for stuff that comes out of the chest? Why does it look so complicated? It’s complicated because the detection/collection of air and fluid require different setups. Most commercial models also allow you to hook the drainage system to wall suction, so you can quickly evacuate the pleural space. This requires its own setup. Because of the need to juggle air, fluid and suction, the most common commercial system includes 3 distinct chambers. If you were to simplify the device, or build one out of spare bottles and tubes, it might look like this:

Wound Healing Phases
Wound Healing Phases Mohamed 21,332 Views • 3 years ago

A video showing the phases of normal wound healing

Before you have LASIK, ask these questions
Before you have LASIK, ask these questions Mohamed Ibrahim 103 Views • 3 years ago

LASIK is one of the most popular elective surgeries in the United States with 95% of patients walking away satisfied with their vision, according to one FDA study. But like with any surgery, there are risks.

beating heart surgery
beating heart surgery Mohamed Ibrahim 36,575 Views • 3 years ago

Beating heart or "off pump" coronary artery surgery is the latest revolution in the management coronary disease. It is being embraced world-wide by increasing numbers of surgeons. Many of the advantages are subtle but reduced mortality, stroke, and bleeding as well as earlier discharge are well-established benefits. A cardiac stabiliser is mandatory for this surgery, most are single use only and very expensive, this one is multiple use and is saving many healthcare dollars

Atrial Septal Defect
Atrial Septal Defect samer kareem 7,531 Views • 3 years ago

atrial septal defect (ASD) is a hole in the wall between the two upper chambers of your heart (atria). The condition is present from birth (congenital). Small atrial septal defects may close on their own during infancy or early childhood. Large and long-standing atrial septal defects can damage your heart and lungs. Small defects may never cause a problem and may be found incidentally. An adult who has had an undetected atrial septal defect for decades may have a shortened life span from heart failure or high blood pressure that affects the arteries in the lungs (pulmonary hypertension). Surgery may be necessary to repair atrial septal defects to prevent complications

Suturing of Uterus
Suturing of Uterus DrHouse 15,144 Views • 3 years ago

A video showing how to suture the uterus during ceseran section

Teeth digital X-Ray
Teeth digital X-Ray Dentist 13,100 Views • 3 years ago

Teeth digital X-Ray

How your body changes in pregnancy
How your body changes in pregnancy samer kareem 13,958 Views • 3 years ago

In your first few months of pregnancy, hormones flood your body. Your baby is still tiny but already your body is changing. Your breasts start to swell and may feel tender. Tiredness, nausea and frequent trips to the loo are common pregnancy symptoms.

Chronic Angina
Chronic Angina samer kareem 7,756 Views • 3 years ago

Chronic angina is a prevalent manifestation of cardiovascular disease and is most commonly due to insufficient oxygen supply from fixed epicardial lesions in the coronary arteries.

Showing 156 out of 373