Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target guanines. Cisplatin can bond more tightly with nitrogen because nitrogen balances the platinum charge more effectively than chlorine. It is this adduct-induced DNA bend that allows binding of proteins which contain the high mobility group, HMG domain. Once the protein is bound to the DNA, it inserts a wedge-like phenyl group of phenylalanine 37 into the widened minor groove created by the bend. The tightly bound HMG protein causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, Cisplatin can be thought of as a monkey wrench in the DNA repair system. With the HMG protein bound to the DNA, the modified strand is not repaired properly and so the cell dies. The success of Cisplatin depends on its ratio of efficacy between cancerous and healthy cells.

Move the person beyond striking distance of the snake. Have the person lie down with wound below the heart. Keep the person calm and at rest, remaining as still as possible to keep venom from spreading. Cover the wound with loose, sterile bandage

USMLE Step 2 CS - Diabetes Mellitus This is just preview video. To get full access please visit our website : www.usmletutoring.com

A video from Loyola medical school, Chicago showing full neonatal medical examination Part 1

TODAY’s Al Roker is back at work, less than two weeks after knee replacement surgery. Al reveals the rigorous course of physical therapy that helped get him back on his feet so quickly. He says the procedure has improved radically since his first knee replacement 15 years ago.
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Inside Al Roker’s Road To Recovery After Knee Replacement | TODAY

An orgasm is a feeling of intense sexual pleasure that happens during sexual activity. It's sometimes called "coming" or "climaxing". Both men and women have orgasms.

This video, Rheumatoid arthritis is a chronic inflammatory disorder that can affect more than just your joints. In some people, the condition also can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels. An autoimmune disorder, rheumatoid arthritis occurs when your immune system mistakenly attacks your own body's tissues. Unlike the wear-and-tear damage of osteoarthritis, rheumatoid arthritis affects the lining of your joints, causing a painful swelling that can eventually result in bone erosion and joint deformity. The inflammation associated with rheumatoid arthritis is what can damage other parts of the body as well. While new types of medications have improved treatment options dramatically, severe rheumatoid arthritis can still cause physical disabilities.

Patty Jackson WDAS Interviews Renee Brown & Nnamdi G. Osuagwu, Co-Founders of The Fibroids Project (FibroidsProject.com).

Early Signs that Cancer is Growing in Your Body

Pediatric Surgery Day Unit (PSDU)
Welcome to Harley Street state-of-the-art Pediatric Surgery Day Unit! We are thrilled to have the opportunity to provide exceptional care and support for our young patients and their families. At our unit, we understand the unique needs and concerns associated with pediatric surgery, and we strive to create a safe and comforting environment for everyone involved.

Compassionate Care by Dedicated Professionals
Lead by Consultant Pediatric Surgeon, Dr. Niall Martin Jones, we will ensure your baby is looked after to the highest possible standards. Our dedicated team and support staff is committed to delivering the highest quality of care. All procedures are performed with local anesthetic and sucrose for comfort. Usually, your baby is so comfortable that she/he will be asleep by the end of the treatment.

Advanced Technology and Safety Measures
Patient safety is our utmost priority. We have implemented rigorous infection control measures to ensure a sterile environment. Our operating rooms are equipped with advanced technology and monitoring systems to ensure the highest standards of safety and precision during surgery. Our anesthesiologists are experienced in administering anesthesia to children, ensuring a smooth and comfortable experience.

learn more https://www.hsmc.ae/our-clinic....s/pediatric-surgery-
#pediatricsurgery #pediatrics #childhealthcare

If you’re like me, you probably hook your chest tube up to a Pleur-Evac, put it on the ground, then back away slowly. Who knows what goes on in that mysterious bubbling white box? Hopefully this will post shed some light. Isn’t this just a container for stuff that comes out of the chest? Why does it look so complicated? It’s complicated because the detection/collection of air and fluid require different setups. Most commercial models also allow you to hook the drainage system to wall suction, so you can quickly evacuate the pleural space. This requires its own setup. Because of the need to juggle air, fluid and suction, the most common commercial system includes 3 distinct chambers. If you were to simplify the device, or build one out of spare bottles and tubes, it might look like this:

A video showing the phases of normal wound healing

LASIK is one of the most popular elective surgeries in the United States with 95% of patients walking away satisfied with their vision, according to one FDA study. But like with any surgery, there are risks.

Beating heart or "off pump" coronary artery surgery is the latest revolution in the management coronary disease. It is being embraced world-wide by increasing numbers of surgeons. Many of the advantages are subtle but reduced mortality, stroke, and bleeding as well as earlier discharge are well-established benefits. A cardiac stabiliser is mandatory for this surgery, most are single use only and very expensive, this one is multiple use and is saving many healthcare dollars

atrial septal defect (ASD) is a hole in the wall between the two upper chambers of your heart (atria). The condition is present from birth (congenital). Small atrial septal defects may close on their own during infancy or early childhood. Large and long-standing atrial septal defects can damage your heart and lungs. Small defects may never cause a problem and may be found incidentally. An adult who has had an undetected atrial septal defect for decades may have a shortened life span from heart failure or high blood pressure that affects the arteries in the lungs (pulmonary hypertension). Surgery may be necessary to repair atrial septal defects to prevent complications

A video showing how to suture the uterus during ceseran section

Teeth digital X-Ray

In your first few months of pregnancy, hormones flood your body. Your baby is still tiny but already your body is changing. Your breasts start to swell and may feel tender. Tiredness, nausea and frequent trips to the loo are common pregnancy symptoms.

Chronic angina is a prevalent manifestation of cardiovascular disease and is most commonly due to insufficient oxygen supply from fixed epicardial lesions in the coronary arteries.