Chronic myeloid leukaemia is a common malignancy worldwide. We have come a long way from the limited treatment options and survival in this condition. Today, CML is a treatable malignancy with more than 80% patients surviving beyond 10 years after diagnosis, in absence of complications. This presentation deals with the definition, diagnostic criteria of chronic phase, accelerated and blastic phase (MD Anderson cancer centre, International bone marrow transplant registry and the WHO for the latter two) and management (first and second generation tyrosine kinase inhibitors) of this condition. Finally, a stepwise approach to chronic myeloid leukaemia is also presented including the definitive modality of treatment, allogeneic stem cell transplantation.

Common types of fractures include: Stable fracture. The broken ends of the bone line up and are barely out of place. Open, compound fracture. The skin may be pierced by the bone or by a blow that breaks the skin at the time of the fracture. ... Transverse fracture. ... Oblique fracture. ... Comminuted fracture.

An omphalocele is a birth defect in which an infant's intestine or other abdominal organs are outside of the body because of a hole in the belly button (navel) area. The intestines are covered only by a thin layer of tissue and can be easily seen.

Sinusitis means your sinuses are inflamed. The cause can be an infection or another problem. Your sinuses are hollow air spaces within the bones surrounding the nose. They produce mucus, which drains into the nose. If your nose is swollen, this can block the sinuses and cause pain. There are several types of sinusitis, including Acute, which lasts up to 4 weeks Subacute, which lasts 4 to 12 weeks Chronic, which lasts more than 12 weeks and can continue for months or even years Recurrent, with several attacks within a year Acute sinusitis often starts as a cold, which then turns into a bacterial infection. Allergies, nasal problems, and certain diseases can also cause acute and chronic sinusitis. Symptoms of sinusitis can include fever, weakness, fatigue, cough, and congestion. There may also be mucus drainage in the back of the throat, called postnasal drip. Your health care professional diagnoses sinusitis based on your symptoms and an examination of your nose and face. You may also need imaging tests. Treatments include antibiotics, decongestants, and pain relievers. Using heat pads on the inflamed area, saline nasal sprays, and vaporizers can also help.

What is tropical sprue? Tropical sprue is diagnosed when somebody has long-standing GI problems and has visited tropical regions in the past. It's thought to be caused by bacterial overgrowth and often leads to villous atrophy.

Osteochondroma. Osteochondromas (osteocartilaginous exostoses), the most common benign bone tumors, may arise from any bone but tend to occur near the ends of long bones. ... Enchondroma. ... Chondroblastoma. ... Chondromyxofibroma. ... Osteoid osteoma. ... Nonossifying fibroma (fibrous cortical defect) ... Benign giant cell tumor of bone.

Your body's immune system protects you from disease and infection. But if you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake. Autoimmune diseases can affect many parts of the body. No one is sure what causes autoimmune diseases. They do tend to run in families. Women - particularly African-American, Hispanic-American, and Native-American women - have a higher risk for some autoimmune diseases. There are more than 80 types of autoimmune diseases, and some have similar symptoms. This makes it hard for your health care provider to know if you really have one of these diseases, and if so, which one. Getting a diagnosis can be frustrating and stressful. Often, the first symptoms are fatigue, muscle aches and a low fever. The classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling. The diseases may also have flare-ups, when they get worse, and remissions, when symptoms get better or disappear. Treatment depends on the disease, but in most cases one important goal is to reduce inflammation. Sometimes doctors prescribe corticosteroids or other drugs that reduce your immune response.

Early Signs that Cancer is Growing in Your Body

Gastric bypass is surgery that helps you lose weight by changing how your stomach and small intestine handle the food you eat. After the surgery, your stomach will be smaller. You will feel full with less food. The food you eat will no longer go into some parts of your stomach and small intestine that absorb food. Because of this, your body will not get all of the calories from the food you eat.

Pancreatic Auto Islet Transplantation is a procedure used to maintain insulin production and secretion in patients with chronic pancreatitis that are undergoing a total pancreatectomy, or removal of the entire pancreas. When all other medical therapies fail to control the pain, removal of the pancreas may be an option; however it can leave a person diabetic, which means that the body can no longer control blood sugar levels, and will require intensive testing of blood sugar and injections of insulin. The pancreas is an organ, located in the upper abdominal cavity, behind the stomach, liver and colon. Within the pancreas, specialized clusters of cells known as islets produce insulin, which maintain healthy blood sugar levels. The pancreas also produces enzymes to help digest food. In order to alleviate pain and maintain insulin production, the pancreas is removed from the body, processed and the islets are harvested. Once the pancreas is removed, it is placed in a solution and put into a machine where the pancreas is digested. The islets are then infused into the patient’s liver. Within a short time, the islets are expected to start producing insulin. In 80% of patients, the pain from pancreatitis is relieved by a total pancreatectomy. Over time, some patients may be diabetic and will need to take insulin to maintain healthy blood sugar levels. All patients will take pancreatic enzymes to help digest food after surgery.

Uncontrolled high blood pressure can lead to stroke by damaging and weakening your brain's blood vessels, causing them to narrow, rupture or leak. High blood pressure can also cause blood clots to form in the arteries leading to your brain, blocking blood flow and potentially causing a stroke. Dementia.

Ovarian teratoma is a type of germ cell tumour. Germ cell tumours are cancers that begin in egg cells in women or sperm cells in men. There are 2 main types of ovarian teratoma. Mature teratoma, which is benign. Immature teratoma, which is cancerous.

Nephritis and Nephrotic Syndrome

What factors should I consider when deciding whether to have surgery? The following factors should be considered when deciding whether to have surgery: Your age—If you have surgery at a young age, there is a chance that prolapse will recur and may possibly require additional treatment. If you have surgery at an older age, general health issues and any prior surgery may affect the type of surgery that you have. Your childbearing plans—Ideally, women who plan to have children (or more children) should postpone surgery until their families are complete to avoid the risk of prolapse happening again after corrective surgery. Health conditions—Any surgical procedure carries some risk, such as infection, bleeding, blood clots in the legs, and problems related to anesthesia. Surgery may carry more risks if you have a medical condition, such as diabetes, heart disease, or breathing problems, or if you smoke or are obese. New problems—Surgery also may cause new problems, such as pain during sex, pelvic pain, or urinary incontinence.

Cardioversion is a medical procedure by which an abnormally fast heart rate (tachycardia) or cardiac arrhythmia is converted to a normal rhythm using electricity or drugs. Synchronized electrical cardioversion uses a therapeutic dose of electric current to the heart at a specific moment in the cardiac cycle.

Cigarette contain tobacco that is very harmful but vaporizers does not contain tobacco. ... The most basic difference between vaping and cigarette usage is that cigarettes require combustion. You need fire to light a cigarette. On the other hand, vaping requires electricity and creates vapor.

Electrical cardioversion is a procedure in which an electric current is used to reset the heart's rhythm back to its regular pattern (normal sinus rhythm). The low-voltage electric current enters the body through metal paddles or patches applied to the chest wall.

The pain is your feet trying to tell you something!

Since the first replant more than 50 years ago, thousands of severed body parts have been reattached, preserving the quality of life for thousands of patients through improved function and appearance that the void remaining after amputation cannot provide. Ronald Malt performed the first replantation on May 23, 1962 at Massachusetts General Hospital on a 12-year-old boy who had his right arm amputated in a train accident. [1, 2] This amputation occurred at the level of the humeral neck.

Reduction techniques can vary in terms of required force, time, equipment, and staff. [7] No single reduction method is successful in every instance; therefore, the clinician should be familiar with several reduction techniques. Techniques commonly used to reduce anterior shoulder dislocations include the following [35, 36, 37, 38, 39] : Stimson maneuver Scapular manipulation External rotation Milch technique Spaso technique Traction-countertraction