How do you make a working human heart? Scientists can turn stem cells into beating heart cells, but getting them to organize into a 3D heart requires a scaffold. At the Massachusetts General Hospital in Boston, Harald Ott and his team are reusing the scaffold that nature provides. They’re stripping away all the living cells from dead hearts, before filling in the leftover matrix with healthy new cells. In this video, Brendan Maher finds out how the technique could be used to develop parts of the heart, like the aortic root and valve, for transplant.

The bladder is a hollow organ in the lower abdomen (pelvis). It collects and stores urine produced by the kidneys. The bladder is connected to the kidneys by a tube from each kidney called a ureter. When the bladder reaches its capacity of urine, the bladder wall contracts, although adults have voluntary control over the timing of this contraction. At the same time, a urinary control muscle (sphincter) in the urethra relaxes. The urine is then expelled from the bladder. The urine flows through a narrow tube called the urethra and leaves the body. This process is called urination, or micturition.

How to approach histology for Human Anatomy students. Using a key will help get you through it! Add some penguin fairy dust will help too!

Please note: I mis-spoke and said "striated" instead of "stratified epithelium" a couple of times... apologies!

There are lots of histology keys out there, but the one I showed in the video is here: http://www.penguinprof.com/upl....oads/8/4/3/1/8431323

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Tissue in the human body:

Epithelial: Is made of cells arranged in a continuous sheet with one or more layers, has apical & basal surfaces.

A basement membrane is the attachment between the basal surface of the cell & the underlying connective tissue.

Two types of epithelial tissues: (1) Covering & lining epithelia and (2) Glandular Epithelium.

The number of cell layers & the shape of the cells in the top layer can classify epithelium.

Simple Epithelium - one cell layer
Stratified epithelium - two or more cell layers
Pseudostratified Columnar Epithelium - When cells of an epithelial tissue are all anchored to the basement Membrane but not all cells reach the apical surface.
Glandular Epithelium -- (1) Endocrine: Release hormones directly into the blood stream and (2) Exocrine - Secrete into ducts.


Connective: contains many different cell types including: fibroblasts, macrophages, mast cells, and adipocytes. Connective Tissue Matrix is made of two materials: ground substance - proteins and polysaccharides, fiber -- reticular, collagen and elastic.

Classification of Connective Tissue:
Loose Connective - fibers & many cell types in gelatinous matrix, found in skin, & surrounding blood vessels, nerves, and organs.
Dense Connective - Bundles of parallel collagen fibers& fibroblasts, found in tendons& ligaments.
Cartilage - Cartilage is made of collagen & elastin fibers embedded in a matrix glycoprotein & cells called chondrocytes, which was found in small spaces.
Cartilage has three subtypes:
Hyaline cartilage -- Weakest, most abundant type, Found at end of long bones, & structures like the ear and nose,
Elastic cartilage- maintains shape, branching elastic fibers distinguish it from hyaline and
Fibrous Cartilage - Strongest type, has dense collagen & little matrix, found in pelvis, skull & vertebral discs.


Muscle: is divided into 3 categories, skeletal, cardiac and smooth.
Skeletal Muscle -- voluntary, striated, striations perpendicular to the muscle fibers and it is mainly found attached to bones.
Cardiac Muscle -- involuntary, striated, branched and has intercalated discs
Smooth Muscle -- involuntary, nonstriated, spindle shaped and is found in blood vessels & the GI tract.


Nervous: Consists of only two cell types in the central nervous system (CNS) & peripheral nervous system (PNS):
Neurons - Cells that convert stimuli into electrical impulses to the brain, and Neuroglia -- supportive cells.
Neurons -- are made up of cell body, axon and dendrites. There are 3 types of neurons:
Motor Neuron -- carry impulses from CNS to muscles and glands,
Interneuron - interpret input from sensory neurons and end responses to motor neurons
Sensory Neuron -- receive information from environment and transmit to CNS.
Neuroglia -- is made up of astrocytes, oligodendrocytes, ependymal cells and microglia in the CNS, and schwann cells and satellite cells in the PNS.

Women's College Hospital is revolutionizing the way knee-replacement surgery is done. It is starting to provide the procedure as an ambulatory service. Patients can go home from hospital four hours after having the surgery. In some other hospitals knee replacement surgery patients have to stay as long as 4 days.

Read an excerpt from Theresa Boyle's story:
It’s been less than four hours since Greg Nemez underwent knee-replacement surgery and the 56-year-old Mississauga man is already on his way home from hospital.

This past Monday, he became the fifth patient at Toronto’s Women’s College Hospital to undergo the outpatient procedure, which normally requires a hospital stay of two or three days.

“I’m happy ... You have that freedom of movement from before. It’s like wow,” he said on the elevator as he was leaving the hospital.

After years of being unable to hold his leg straight, the real-estate agent can finally do so. A 20-year-old football injury had left him with severe arthritis and pain.

Read the full story:
https://www.thestar.com/news/g....ta/2018/04/11/he-got

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Because the continuous supply of glucose is stopped after birth, the neonate develops hypoglycemia because of insufficient substrate. Stimulation of fetal insulin release by maternal hyperglycemia during labor significantly increases the risk of early hypoglycemia in these infants.

Acetaminophen and ibuprofen are both good medicines, and both provide the same basic relief from fever and pain, even though they have different chemical structures and side effects

Has your dentist or endodontist told you that you need root canal treatment? If so, you're not alone. Millions of teeth are treated and saved each year with root canal, or endodontic, treatment. Remember, root canal treatment doesn't cause pain, it relieves it. Watch our videos below to learn more! Inside the tooth, under the white enamel and a hard layer called the dentin, is a soft tissue called the pulp. The pulp contains blood vessels, nerves and connective tissue, and helps to grow the root of your tooth during development. In a fully developed tooth, the tooth can survive without the pulp because the tooth continues to be nourished by the tissues surrounding it.

stop gunshot wound bleeding in 15 seconds

20 Reasons to Drink Lemon Water

A central venous catheter, also called a central line, is a long, thin, flexible tube used to give medicines, fluids, nutrients, or blood products over a long period of time, usually several weeks or more. A catheter is often inserted in the arm or chest through the skin into a large vein.

The uterus, or womb, is an important female reproductive organ. It is the place where a baby grows when a women is pregnant. There are different types of uterine cancer. The most common type starts in the endometrium, the lining of the uterus. This type of cancer is sometimes called endometrial cancer. The symptoms of uterine cancer include Unusual vaginal bleeding or discharge Trouble urinating Pelvic pain Pain during intercourse Uterine cancer usually occurs after menopause. Being obese and taking estrogen-alone hormone replacement therapy (also called menopausal hormone therapy) also increase your risk. Treatment varies depending on your overall health, how advanced the cancer is and whether hormones affect its growth. Treatment is usually a hysterectomy, which is surgery to remove the uterus. The ovaries and fallopian tubes are also removed. Other options include hormone therapy and radiation.

Do you need to do a parasite cleanse? Probably... I hear from so many people suffering from symptoms of parasites - severe bloating, cramps, constipation, diarrhoea. A big problem in getting to the bottom of this (pun intended) is that the mainstream medical system really doesn’t have a way to detect, or even find most forms of parasites. They give you drugs for the symptoms, but essentially the parasites aren’t removed during that process.

procedure is usually done in the hospital or outpatient surgical center under general anesthesia (while you are asleep and pain-free). The procedure is performed in the following way: The surgeon makes a small cut (incision) below the belly button (navel). A needle or tube is inserted into the incision. Carbon dioxide gas is passed into the abdomen through the needle or tube. The gas helps expand the area, giving the surgeon more room to work, and helping the surgeon see the organs more clearly. A tube is placed through the cut in your abdomen. A tiny video camera (laparoscope) goes through this tube and is used to see the inside of your pelvis and abdomen. More small cuts may be made if other instruments are needed to get a better view of certain organs. If you are having gynecologic laparoscopy, dye may be injected into your cervix area so the surgeon can view your fallopian tubes. After the exam, the gas, laparoscope, and instruments are removed, and the cuts are closed. You will have bandages over those areas.

Neck Examination - Cervical Spine Assessment - Clinical Skills - Dr Gill

Compose a new pain within athletes is cervical spine discomfort, thankfully in the vast majority of cases when the neck is examined the cause of the neck pain is found to be muscular.

However, pain can also refer from the neck to the arm, in which case it is important to be able to assess for cervical radiculopathy prior to gaining more information which may indicate an MRI is needed

We assess for radiculopathy by doing Spurling's test, an often overlooked part of the neck examination, but it should be included for completeness and reassurance of the patient - not forgetting the athlete or not, neck pain can be a considerable source of distress, so it's vital to be able to get information from the neck examination which allows you to safely reassure a patient when appropriate, or comment that neck exam found evidence that needs further investigation

#DRGill #neck #asmr

Multiple myeloma is a cancer formed by malignant plasma cells. Normal plasma cells are found in the bone marrow and are an important part of the immune system. The immune system is made up of several types of cells that work together to fight infections and other diseases. Lymphocytes (lymph cells) are the main cell type of the immune system. The major types of lymphocytes are T cells and B cells.

What does the placenta do? The placenta is an organ that develops in your uterus during pregnancy. This structure provides oxygen and nutrients to your growing baby and removes waste products from your baby's blood. The placenta attaches to the wall of your uterus, and your baby's umbilical cord arises from it. In most pregnancies, the placenta attaches at the top or side of the uterus.

Heart sounds are the noises generated by the beating heart and the resultant flow of blood through it. Specifically, the sounds reflect the turbulence created when the heart valves snap shut. In cardiac auscultation, an examiner may use a stethoscope to listen for these unique and distinct sounds that provide important auditory data regarding the condition of the heart. In healthy adults, there are two normal heart sounds often described as a lub and a dub (or dup), that occur in sequence with each heartbeat. These are the first heart sound (S1) and second heart sound (S2), produced by the closing of the atrioventricular valves and semilunar valves, respectively. In addition to these normal sounds, a variety of other sounds may be present including heart murmurs, adventitious sounds, and gallop rhythms S3 and S4.

It can treat spider veins and tiny varicose veins just under the skin's surface. ... (If you have poor blood circulation feeding these tiny veins, the larger "feeder" vein must first be treated with surgery, endovenous laser or radiofrequency treatment, or sclerotherapy.) Endovenous laser treatment.

In most cases, your body's immune system defeats an HPV infection before it creates warts. When warts do appear, they vary in appearance depending on which variety of HPV is involved: Genital warts. These appear as flat lesions, small cauliflower-like bumps or tiny stem-like protrusions. In women, genital warts appear mostly on the vulva but can also occur near the anus, on the cervix or in the vagina. In men, genital warts appear on the penis and scrotum or around the anus. Genital warts rarely cause discomfort or pain, though they may itch. Common warts. Common warts appear as rough, raised bumps and usually occur on the hands, fingers or elbows. In most cases, common warts are simply unsightly, but they can also be painful or susceptible to injury or bleeding.

Mini-invasive surgical repair of a ruptured Achilles tendon