Transjugular intrahepatic portosystemic shunt or transjugular intrahepatic portosystemic stent shunting (commonly abbreviated as TIPS or TIPSS) is an artificial channel within the liver that establishes communication between the inflow portal vein and the outflow hepatic vein.

Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target guanines. Cisplatin can bond more tightly with nitrogen because nitrogen balances the platinum charge more effectively than chlorine. It is this adduct-induced DNA bend that allows binding of proteins which contain the high mobility group, HMG domain. Once the protein is bound to the DNA, it inserts a wedge-like phenyl group of phenylalanine 37 into the widened minor groove created by the bend. The tightly bound HMG protein causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, Cisplatin can be thought of as a monkey wrench in the DNA repair system. With the HMG protein bound to the DNA, the modified strand is not repaired properly and so the cell dies. The success of Cisplatin depends on its ratio of efficacy between cancerous and healthy cells.

Watch that Full Human Body Decay Process Video

Watch that Medical Abortion Surgical Procedure

Watch that Full Human Dead Body Decomposing Video

Watch that video of the Worlds largest Face Abscess Draining

We are looking for 5 patients with knee pain who want to get significantly better in the next 30 days. Click this link to let me know you're interested and learn more.

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One of the most common knee injuries in contact and collision sports is a medial collateral ligament (MCL) injury. This is a ligament on the medial (side closest to the midline) side of your knee that provides stability against side-to-side stress to the knee. You might injure it by cutting maneuvers in sports like soccer or hockey. You can also suffer an MCL injury if another player hits you on the outside of your knee.

Please note: I don't respond to questions and requests for specific medical advice left in the comments to my videos. I receive too many to keep up (several hundred per week), and legally I can't offer specific medical advice to people who aren't my patients (see below). If you want to ask a question about a specific injury you have, leave it in the comments below, and I might answer it in an upcoming Ask Dr. Geier video. If you need more detailed information on your injury, go to my Resources page: https://www.drdavidgeier.com/resources/

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Unlike tears of the ACL, MCL injuries most often heal without surgery. You might need to wear a hinged knee brace for 2-6 weeks. The length of time you miss from sports or exercise varies depending on the location and severity of the injury.

In this video, I share my thoughts on the nature of an MCL injury, the diagnosis, the treatment options and return to sports.

Please remember, while I appreciate your questions, I cannot and will not offer specific medical advice by email, online, on my show, or in the comments at the end of these posts. My responses are meant to provide general medical information and education. Please consult your physician or health care provider for your specific medical concerns.

INDICATIONS Administration of agents into the central vasculature Central circulation and intracardiac access Maintenance of venous access Hemodialysis and plasmapheresis

Our General Surgery team treats hernia patients on a daily basis. In fact, you could consider them to be hernia experts. We sat down with one of those experts, Dr. Heater Dunlap, to talk about the common signs and symptoms of hernias and to answer the question of when to see a doctor.

Transradial Cardiac Catheterization

Dr. Mohan Rao, Senior General & Laparoscopic consultant at Apollo Spectra Hospitals, MRC Nagar explains How can one self-examination of Hernia be done

Ischemic colitis occurs when blood flow to part of the large intestine (colon) is reduced, usually due to narrowed or blocked blood vessels (arteries). The diminished blood flow doesn't provide enough oxygen for the cells in your digestive system. Ischemic colitis can cause pain and may damage your colon. Any part of the colon can be affected, but ischemic colitis usually causes pain on the left side of the belly area (abdomen). The condition can be misdiagnosed because it can easily be confused with other digestive problems. Ischemic colitis may heal on its own. But you may need medication to treat ischemic colitis or prevent infection, or you may need surgery if your colon has been damaged. Symptoms ShareTweet Oct. 13, 2015 References Products and Services Newsletter: Mayo Clinic Health Letter See also Abdominal pain Colonoscopy Color Blue Detects Colon Cancer CT scan CT scans: Are they safe? Diarrhea Ultrasound Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship PolicyOpportunitiesAd Choices Mayo Clinic Store Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. NEW! – The Mayo Clinic Diet, Second Edition Treatment Strategies for Arthritis Mayo Clinic on Better Hearing and Balance Keeping your bones healthy and strong The Mayo Clinic Diet Online Ads by Swoop Psoriasis Treatment www.informationaboutpsoriasis.com Explore a Treatment Option for Moderate to Severe Plaque Psoriasis Immune Biomarker PD-L1 - Discover the Science iobiomarkers.bmsinformation.com Understanding Assay Results for PD-L1 is Crucial for Treatment Decisions. Biomarker PD-L1 Information - Easy to Download Resources iobiomarkers.bmsinformation.com Explore the Role of PD-L1 in Immuno-Oncology & the Evolving Biomarker Landscape.

Carpal Tunnel Syndrome Self Test

Our results in this study of MIPO treated with conventional plates are comparable to the results of the femoral shaft fractures treated with intramedullary nailing. The technique can be used for all femoral shaft fractures. Although the biomechanics of the plate fixation are less stable compared to the intamedullary nail, the mechanical stability is stable enough for bone healing. Healing was rapid, and postoperative care was simplified. The two major complications were malalignment and screw breakage. We recommend using at least three separated screws in each fragment to prevent stress on the screw and screw breakage. Intraoperative limb length, axial alignment, and rotation must be carefully assessed to prevent malalignment. The limitations of our study include lack of a comparison group, retrospective data collection, and no randomisation in outcome evaluation

External jugular vein cannulation is an integral part of modern medicine and is practiced in virtually every health care setting. Venous access allows sampling of blood, as well as administration of fluids, medications, parenteral nutrition, chemotherapy, and blood products. [1] This topic describes placement of an intravenous (IV) catheter into the external jugular vein. A similar technique can be used for placement of IV catheters at different anatomic sites.

This video: Polycythemia vera (pol-e-sigh-THEE-me-uh VEER-uh) is a slow-growing type of blood cancer in which your bone marrow makes too many red blood cells. Polycythemia vera may also result in production of too many of the other types of blood cells — white blood cells and platelets. These excess cells thicken your blood and cause complications, such as such as a risk of blood clots or bleeding. Polycythemia vera isn't common. It usually develops slowly, and you may have it for years without noticing signs or symptoms. Often, polycythemia vera is found during a blood test done for some other reason. Without treatment, polycythemia vera can be life-threatening. However, with proper medical care, many people experience few problems related to this disease. Over time, there's a risk of progressing to more-serious blood cancers, such as myelofibrosis or acute leukemia.

Cervical artificial disc replacement using the BRYAN Disc, a trusted product of Medtronic. Spine care offices are located in New Jersey, New York, and Florida. Are you experiencing neck pain? Do you think you may have a herniate disc? Learn more about our doctors' 97% success rate for performing BRYAN disc replacement:

Femoroacetabular impingement (FAI) is a condition in which extra bone grows along one or both of the bones that form the hip joint — giving the bones an irregular shape. Because they do not fit together perfectly, the bones rub against each other during movement. Over time this friction can damage the joint, causing pain and limiting activity.

The spleen is one of the most overlooked organs. Rarely does it get attention unless there is some kind of accident or trauma. However, I find spleen dysfunction to be very prevalent. This video talks about some of the symptoms.

Endovascular Aneurysm Repair Endovascular aneurysm repair (or endovascular aortic repair) (EVAR) is a type of endovascular surgery used to treat pathology of the aorta, most commonly an abdominal aortic aneurysm (AAA).