Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication. The mechanism involved in its activity against rheumatoid arthritis is not known.

This medical animation illustrates how acute myeloid leukemia (AML), the most common type of cancer in adults, develops in the blood and bone marrow. The narrator also discusses the symptoms of AML and AML treatment options.

Hip dysplasia is the medical term for a hip socket that doesn't fully cover the ball portion of the upper thighbone. This allows the hip joint to become partially or completely dislocated

The surgical procedure uses your own fat, so it is the most natural way to augment your buttocks. Over the last few years, the buttocks have received more press coverage than ever before. People of all ages and body types are having the Brazilian Butt Lift procedure.

A deep cut on the palm side of your fingers, hand, wrist, or forearm can damage your flexor tendons, which are the tissues that help control movement in your hand. A flexor tendon injury can make it impossible to bend your fingers or thumb.

The "great arteries" in this anomaly refer to the aorta and the pulmonary artery, the two major arteries carrying blood away from the heart. In cases of transposition of the great arteries, these vessels arise from the wrong ventricle. They are "transposed" from their normal position so that the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. Other heart defects may occur along with transposition of the great arteries. About 25 percent of children with transposition will also have a ventricular septal defect (VSD) . In nearly a third, the branching pattern of the coronary arteries as they leave the transposed aorta is unusual. Infants may also have narrowing below the pulmonary valve that blocks blood flow from the left ventricle to the lungs.

Dr. Kathryn Baerman is a Board Certified General Surgeon specializing in Women's Health and Breast Care. She shares with us that in women, hernias present differently than in men. If you are experiencing groin pain, it may be a hernia.

To visit Dr. Baerman in Apex, Chapel Hill, or Durham, North Carolina, call 919-281-1699 to schedule an appointment with her at EmergeOrtho.

Jaw surgery, also known as orthognathic (or-thog-NATH-ik) surgery, corrects irregularities of the jaw bones and realigns the jaws and teeth to improve the way they work. Making these corrections may also improve your facial appearance. Jaw surgery may be a corrective option if you have jaw problems that can't be resolved with orthodontics alone. In most cases, you also have braces on your teeth before surgery and during recovery after surgery until healing and alignment are complete. Your orthodontist can work with your oral and jaw and face (maxillofacial) surgeon to determine your treatment plan.

Alcohol septal ablation (ASA, TASH, Sigwart procedure) is a percutaneous, minimally-invasive treatment performed by an interventional cardiologist to relieve symptoms and improve functional status in severely symptomatic patients with hypertrophic cardiomyopathy (HCM) who meet strict clinical, anatomic and physiologic ...

“Endo” is the Greek word for “inside” and “odont” is Greek for “tooth.” Endodontic treatment treats the inside of the tooth. Root canal treatment is one type of endodontic treatment. To understand endodontic treatment, it helps to know something about the anatomy of the tooth. Inside the tooth, under the white enamel and a hard layer called the dentin, is a soft tissue called the pulp. The pulp contains blood vessels, nerves, and connective tissue and creates the surrounding hard tissues of the tooth during development.

There’s a strange, mysterious world inside us, an alien-looking environment that turns the food we eat into nutrients that keep us alive. Michael Mosley swallows a camera to take a closer look.

Echo Therapeutics Symphony tCGM Continuous Glucose Monitor

Inserting the Enlite Sensor with insulin pump

Pediatric orthopedic surgeons at Columbia are using a new device with magnetic technology that avoids the need for multiple spine-lengthening surgeries to correct early-onset scoliosis, a severe curvature of the spine in young children. In April 2014, Michael Vitale, MD, the Ana Lucia Professor of Pediatric Orthopedic Surgery at CUMC and 1995 graduate of P&S, performed the first procedure in the New York area, using the device to treat a 5-year-old boy. When braces and casts cannot control scoliosis in young children, surgeons turn to growing rods, which help correct the curve while allowing the spine to grow. When spinal maturity is near, the rods are removed and a spinal fusion can be performed. But during years of treatment with growing rods, patients must undergo surgery every six months to lengthen the rods to keep up with the patients’ growth. A patient may undergo eight to 10 procedures, which are costly and result in lost time for parents at work and children at school. The new device—MAGEC (MAGnetic Expansion Control) rods—contains a mechanism inside the growing rods that allows surgeons to lengthen the rods with a handheld external magnet, without surgery.

Nystagmus is a condition of involuntary (or voluntary, in rare cases) eye movement, acquired in infancy or later in life, that may result in reduced or limited vision. Due to the involuntary movement of the eye, it has been called "dancing eyes"

Symptoms of blood clots in specific body locations are as follows: Symptoms of blood clots in legs (deep vein thrombosis (DVT) are pain, redness, and swelling. Symptoms of an arterial blood clot in a limb (leg or arm) include pain, pale color, and coolness to the touch. and the leg is cool and pale.

Spermicide is a birth control method that contains chemicals that stop sperm from moving. Spermicides are available in different forms, including creams, film, foams, gels, and suppositories. Spermicide can be used alone, or it can be used with other birth control methods to make them more effective. It is always used with the diaphragm and cervical cap.

Lots of people wonder: does the pull out method work to prevent pregnancy? Pull out method effectiveness depends on whether or not you do it correctly. Learn more about pulling out in this video.

#lasik #eyesurgery #BusinessInsiderIndia #lasereyesurgery

Business Insider's Michelle Yan has been nearsighted since she was 9 years old. After laser eye surgery, she has 20/20. She walks us through the pre-surgery steps, the actual surgery which the doctor referred to as a spa for eyes, as well as the recovery process.

Don't miss the suggestions and recommendations she has for all those who are planning to undergo laser eye surgery for themselves, towards the end.

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What It's Like To Get Laser Eye Surgery

How to examine a patient's wrist if you suspect a scaphoid fracture: by Cape Town Emergency Medicine