The vast majority of glucocorticoid activity in most mammals is from cortisol, also known as hydrocortisone. Corticosterone, the major glucocorticoid in rodents, is another glucocorticoid. Cortisol binds to the glucocorticoid receptor in the cytoplasm and the hormone-receptor complex is then translocated into the nucleus, where it binds to its DNA response element and modulates transcription from a battery of genes, leading to changes in the cell's phenotype. Only about 10% of circulating cortisol is free. The remaining majority circulates bound to plasma proteins, particularly corticosteroid-binding globulin (transcortin). This protein binding likely decreases the metabolic clearance rate of glucocorticoids and, because the bound steroid is not biologically active, tends to act as a buffer and blunt wild fluctuations in cortisol concentration.

Cervical Mucus

How to Check Cervical Mucus

Bioprosthetic valves used in heart valve replacement generally offer functional properties that are more similar to those of native valves.

This was a Nasogastric Intubation that went very wrong. The tube went up into the brain, causing severe damage, instead of going down through the throat.

Surgical repair of a coexisting ruptured sinus of Valsalva into the RV along with closure of a VSD

Overbite is a type or malocclusion or an overjet. A lot of people don’t realize that they have an overbite, as they believe their condition is not serious enough to obtain dental attention. This could also for the reason that other cases of overbites are so minor to be noticeable. However, others have serious overbite condition that can make the person’s top jaw look much larger or the bottom jaw significantly smaller. But one thing to remember, overbite can actually cause some dental problems. This condition can change the structure of your face and affect the way you talk. The most popular form of overbite correction is orthodontic treatment. Your dentist will fix the overbite with the help of rubber bands and dental braces to pull the upper teeth back. Tooth extraction may be suggested if overcrowding complicates the overbite so as to provide room for your front teeth. In extreme conditions, overbite surgery may be needed to place your jaw backwards or forwards. Furthermore, if severe overbite is not corrected during adulthood, the teeth may continue to shift and trigger dental issues such as gum disease.

This medical 3D animation exhibit shows the left brachial plexus during birth and shoulder dystocia. Anatomy: symphysis pubis, uterus, sacrum, coccyx and fetus. "McRoberts Position". An episiotomy is cut. Brachial Plexus stretch injury. Retraction of head (turtle sign). Suprapubic pressure, gentle traction. To view our medical library of exhibits,

This animated video is an informative video that provides information regarding Upper Gastro-intestinal Endoscopy. An upper GI endoscopy procedure allows your doctor to view the mucus lining of the upper portion of your gastro-intestinal tract. This includes your oesophagus, stomach and duodenum. Upper endoscopy is used to evaluate symptoms of persistent upper abdominal pain, nausea, vomiting, bleeding, or difficulty in swallowing. The procedure is performed using an endoscope which is a long thin flexible tube a light and a tiny video camera attached to the end. The camera transmits the image to a monitor. Uncomplicated upper endoscopy takes 10-20 minutes, your doctor will gently insert the endoscope through your mouth and then slowly and carefully move it down your oesophagus until it reaches your stomach. An endoscopy for stomach may also be necessary in some cases.

An animated description of the use of a cannulated Herbert screw for surgical treatment of scaphoid fractures.

Most people with TS are not significantly impaired by their symptoms and therefore do not require treatment with medication. However, several medications are available to control TS symptoms that interfere with functioning. Except in more severe cases when tics are sometimes painful, the main reasons for medication are to improve appearance and lessen embarrassing social interactions. As with all medications, there are possible side effects that should be monitored carefully by the physician. Patients should always be included in the decision to take medication, as they are the best judge of how disruptive the symptoms are to them. Early diagnosis and treatment are crucial to help the person with TS cope with his or her condition. Often, people make fun of a person with TS. Parents of children with TS also may find it difficult to cope with their child's behavior. When people with TS are diagnosed correctly and treated for the condition early, they can learn to cope with their disorder and accept that they are ok and normal.

Bartter syndrome, originally described by Bartter and colleagues in 1962, [1] represents a set of closely related, autosomal recessive renal tubular disorders characterized by hypokalemia, hypochloremia, metabolic alkalosis, and hyperreninemia with normal blood pressure. The underlying renal abnormality results in excessive urinary losses of sodium, chloride, and potassium.

In Reye's syndrome, a child's blood sugar level typically drops while the levels of ammonia and acidity in his or her blood rise. At the same time, the liver may swell and develop fatty deposits. Swelling may also occur in the brain, which can cause seizures, convulsions or loss of consciousness. The signs and symptoms of Reye's syndrome typically appear about three to five days after the onset of a viral infection, such as the flu (influenza) or chickenpox, or an upper respiratory infection, such as a cold

The brain is the most complex organ in our body. It controls everything we do, from simple things such as breathing, to complex things such as co-ordinating our movements. The brain stores our memories, allows us to think and speak, and controls how we behave

Therapeutic anticoagulation is recommended for all women with acute VTE; prophylactic anticoagulation is recommended for women at risk, such as those with a past history of thrombosis or thrombophilia or with a mechanical heart valve. The preferred anticoagulants during pregnancy are the heparin compounds.

These air sacs make up most of the lung tissue. Lung diseases affecting the alveoli include: Pneumonia: An infection of the alveoli, usually by bacteria. Tuberculosis: A slowly progressive pneumonia caused by the bacteria Mycobacterium tuberculosis. Chronic respiratory diseases are chronic diseases of the airways and other structures of the lung. Some of the most common are: asthma, chronic obstructive pulmonary disease, occupational lung diseases and pulmonary hypertension.

The famous question: Can I get LASIK surgery to correct my vision?

Primary spontaneous pneumothorax is an abnormal accumulation of air in the space between the lungs and the chest cavity (called the pleural space) that can result in the partial or complete collapse of a lung. This type of pneumothorax is described as primary because it occurs in the absence of lung disease such as emphysema. Spontaneous means the pneumothorax was not caused by an injury such as a rib fracture. Primary spontaneous pneumothorax is likely due to the formation of small sacs of air (blebs) in lung tissue that rupture, causing air to leak into the pleural space. Air in the pleural space creates pressure on the lung and can lead to its collapse. A person with this condition may feel chest pain on the side of the collapsed lung and shortness of breath.

In Deep Vein Thrombosis, blood clot is able to reach the heart and from there it transport to the arteries of the lungs, where it may stuck in the...

Baby Mucus Removal - Is This Right Way???