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Osteoarthritis is a degenerative joint disease that is caused by the chronic breakdown and eventual loss of cartilage within the joints. As the cartilage wears away, the bones that meet at the joint begin to rub against each other. This can cause extreme pain and can severely reduce movement and flexibility of the joint. Growths of bone, called bone spurs, can also form around the edges of the joint and cause pain. Joint swelling can also occur if the synovial membrane lining the joint becomes irritated, producing excess fluid that collects inside the joint. What Causes Osteoarthritis? More than half of the population age 65 or older have osteoarthritis in at least one joint. Osteoarthritis usually results from injury to a joint or from wear and tear over time. Heredity, lack of use, and being overweight also contribute to the development of osteoarthritis. Treating Osteoarthritis Treatment can include weight loss, physiotherapy, and medication. If the condition becomes severe and mobility is greatly reduced, hip replacement surgery may be necessary.
Classical PKU is an autosomal recessive disorder, caused by mutations in both alleles of the gene for phenylalanine hydroxylase (PAH), found on chromosome 12. In the body, phenylalanine hydroxylase converts the amino acid phenylalanine to tyrosine, another amino acid.