There are 3 genetic types of FHH based on chromosome location. FHH type 1 accounts for 65% of cases and is due to inactivating mutations in the CASR gene, localized to 3q21.1. This gene encodes the calcium-sensing receptor (CaSR). Loss of CaSR function results in a reduction in the sensitivity of parathyroid and renal cells to calcium levels so hypercalcemia is perceived as normal. The other 35% have either a mutation GNA11 (19p13.3) seen in FHH type 2 or AP2S1 (19q13.2-q13.3) seen in FHH type 3 (see these terms) or in genes not yet discovered. FHH is rarely caused by auto-antibodies against CaSR in those without a mutation.

Cervical Mucus

How to Check Cervical Mucus

Device that keeps a donor heart beating

Bioprosthetic valves used in heart valve replacement generally offer functional properties that are more similar to those of native valves.

A retroverted uterus (tilted uterus, tipped uterus) is a uterus that is tilted posteriorly. This is in contrast to the slightly "anteverted" uterus that most women have, which is tipped forward toward the bladder, with the anterior end slightly concave.

The differential diagnosis for this child's painless hematochezia includes Meckel's diverticulum as well as vascular malformations. Meckel's diverticulum results from a failure of the vitelline duct to obliterate during the first 8 weeks of gestation, leaving behind a blind pouch often containing ectopic gastric tissue. Meckel's diverticulum classically affects children age ~:2 but can also occur in older children or even adults. Young children are more likely to experience painless bleeding due to mucosal irritation from gastric acid; adolescents and adults are more likely to have signs of obstruction. A technetium-99 nuclear scan will identify the diverticulum, which is usually located in the right lower quadrant of the abdomen within 2 feet of the ileocecal valve. Technetium-99 concentrates in the parietal cells of the diverticulum and stomach. The scan is also known as "Meckel's scan" due to its high specificity. A symptomatic Meckel's diverticulum is generally treated with surgical resection.

A nephron (from Greek νεφρός (nephros) meaning "kidney") is the basic structural and functional unit of the kidney. Its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood, reabsorbing what is needed and excreting the rest as urine.

Simple technique to harvest Connective tissue graft from the Palate.

An animated description of the use of a cannulated Herbert screw for surgical treatment of scaphoid fractures.

The cause of pectus excavatum is not known however it can run in families, with up to 25 percent of affected patients reporting chest wall abnormalities in other family members. Pectus excavatum occurs in approximately 1 out of 400–1000 children and is three to five times more common in males than females.

Womb Fight amazing

knife spoon and toothbrush removed from stomach

This video shows the technique of suprapatellar tibial nailing as used for a segmental tibia fracture. The broken leg was treated with the nail to allow immediate mobility and range of motion; no cast was needed for this injury.

Frontotemporal dementia (frontotemporal lobar degeneration) is an umbrella term for a diverse group of uncommon disorders that primarily affect the frontal and temporal lobes of the brain — the areas generally associated with personality, behavior and language. In frontotemporal dementia, portions of these lobes shrink (atrophy). Signs and symptoms vary, depending upon the portion of the brain affected. Some people with frontotemporal dementia undergo dramatic changes in their personality and become socially inappropriate, impulsive or emotionally indifferent, while others lose the ability to use language.

The brain is the most complex organ in our body. It controls everything we do, from simple things such as breathing, to complex things such as co-ordinating our movements. The brain stores our memories, allows us to think and speak, and controls how we behave

Alzheimer’s disease is the most common cause of dementia and also the best understood. It is thought to be caused by the formation of abnormal deposits of protein in the brain.

TRANSUMBILICAL SINGLE SITE LAP CHOLYCYSTECTOMY

Our results in this study of MIPO treated with conventional plates are comparable to the results of the femoral shaft fractures treated with intramedullary nailing. The technique can be used for all femoral shaft fractures. Although the biomechanics of the plate fixation are less stable compared to the intamedullary nail, the mechanical stability is stable enough for bone healing. Healing was rapid, and postoperative care was simplified. The two major complications were malalignment and screw breakage. We recommend using at least three separated screws in each fragment to prevent stress on the screw and screw breakage. Intraoperative limb length, axial alignment, and rotation must be carefully assessed to prevent malalignment. The limitations of our study include lack of a comparison group, retrospective data collection, and no randomisation in outcome evaluation

Sarcoidosis is an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands. In people with sarcoidosis, abnormal masses or nodules (called granulomas) consisting of inflamed tissues form in certain organs of the body. These granulomas may alter the normal structure and possibly the function of the affected organ(s).