The vast majority of glucocorticoid activity in most mammals is from cortisol, also known as hydrocortisone. Corticosterone, the major glucocorticoid in rodents, is another glucocorticoid. Cortisol binds to the glucocorticoid receptor in the cytoplasm and the hormone-receptor complex is then translocated into the nucleus, where it binds to its DNA response element and modulates transcription from a battery of genes, leading to changes in the cell's phenotype. Only about 10% of circulating cortisol is free. The remaining majority circulates bound to plasma proteins, particularly corticosteroid-binding globulin (transcortin). This protein binding likely decreases the metabolic clearance rate of glucocorticoids and, because the bound steroid is not biologically active, tends to act as a buffer and blunt wild fluctuations in cortisol concentration.

How to Check Cervical Mucus

A febrile seizure is a convulsion in a child that may be caused by a spike in body temperature, often from an infection. Your child's having a febrile seizure can be alarming, and the few minutes it lasts can seem like an eternity. Febrile seizures represent a unique response of a child's brain to fever, usually the first day of a fever. Fortunately, they're usually harmless and typically don't indicate an ongoing problem. You can help by keeping your child safe during a febrile seizure and by comforting him or her afterward.

The superior sagittal sinus (also known as the superior longitudinal sinus), within the human head, is an unpaired area along the attached margin of falx cerebri. It allows blood to drain from the lateral aspects of anterior cerebral hemispheres to the confluence of sinuses.

Cerebral palsy refers to brain damage that occurs before a child is five years old. Therefore, adults cannot develop cerebral palsy. However, cerebral palsy does not get better or worse with age, so when a child has the condition, he or she will continue to have the condition into adulthood.

Watch that video to know How to Get Rid of Blackheads From Your Nose

In developing countries, domestic animals (eg, dogs) are common sources of infection. In the United States, bats and wild animals (eg, raccoons) are the most common reservoirs of infection. The acquisition of rabies from bats can occur from an unrecognized bite or a scratch, and possibly by inhalation of aerosolized viral particles. Bats are found in all states except Hawaii, and spelunking (cave exploration) is a risk factor for rabies acquisition from bats.

Two types of clinically distinct necrotizing fasciitis have been described. The most common form (type II) usually occurs in individuals with no concurrent medical illness. Many patients report a history of laceration, blunt trauma, or a surgical procedure as a predisposing factor. It is typically caused by group A Streptococcus (Streptococcus pyogenes). In contrast, type I is usually seen in patients with underlying diabetes and peripheral vascular disease. It is generally a polymicrobial infection; some commonly isolated organisms include Staphylococcus aureus, Bacteroides tragi/is, Escherichia coli, group A Streptococcus, and Pre vote/fa species. Crepitus is more common if anaerobic organisms, such as Clostridium perfringens or 8 tragi/is, are involved.

An antecedent upper respiratory infection is present in 50% of patients. Abdominal pain is a presenting symptom in 1 0-15% of patients. The skin lesions are symmetric, involve dependent parts of the body, and classically progress from an erythematous, macular rash to papular purpura. The joints and kidneys are also commonly involved

Home > Baby > Breastfeeding > Top 10 Tips for Boosting Your Breast Milk Supply Top 10 Tips for Boosting Your Breast Milk Supply COMMENTS () | PRINT A nursing mom’s biggest worry is whether or not she’s making enough milk. We’ve gathered 10 tips to help you bump up your milk production. This gallery is not intended to substitute medical advice. If you have any concerns, contact a lactation consultant or your healthcare provider immediately. 1. Nurse, Nurse, Nurse Breasts work on demand. The more your little one nurses, the more milk your body will create. When your little one is going through a growth spurt, it’s easy to fall into thinking, “my baby is so hungry I must not have enough milk.” What’s really happening is your baby is priming your body to have enough milk to support how big your baby will be after the spurt. The worst thing for your supply is to supplement with formula during a growth spurt. It can be hard to devote most of your day to nursing, but it’s the best thing for your baby, and your supply.

-The management of diaper rash includes frequent changing of diapers, avoiding tight-fitting diapers, exposing the skin to air, using diapers with super absorbent surfaces, and applying barrier creams such as zinc oxide or petrolatum.

-Osler-Rendu-Weber syndrome is characterized by multiple telangiectasias and vascular lesions of the CNS.

Chorionic villus sampling, often referred to as CVS, is a diagnostic test for identifying chromosome abnormalities and other inherited disorders. This test may be recommended by your health care provider, if you or your partner has family medical histories that reveal potential risks.

The cause of HELLP syndrome is unknown, but there are certain factors that may increase your risk of developing it. Preeclampsia is the greatest risk factor. This condition is marked by high blood pressure and swelling, and it typically occurs during the last trimester of pregnancy.

Definition. The principal signs of cerebellar dysfunction are the following: Ataxia: unsteadiness or incoordination of limbs, posture, and gait. A disorder of the control of force and timing of movements leading to abnormalities of speed, range, rhythm, starting, and stopping.

Marcus Greatens, M.D., an orthopedic surgeon at Mayo Clinic Health System provides insight into a few of the things patients can expect to experience during knee replacement surgery.

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Orthopedic surgeon Donald Polakoff, MD describes recovery time from knee replacement surgery.

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This is a surgical video demonstrating the release and skin grafting of the middle and ring fingers. It demonstrates the marking, dissection, and repair of the fingers.

This medical animation illustrates how acute myeloid leukemia (AML), the most common type of cancer in adults, develops in the blood and bone marrow. The narrator also discusses the symptoms of AML and AML treatment options.