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Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target guanines. Cisplatin can bond more tightly with nitrogen because nitrogen balances the platinum charge more effectively than chlorine. It is this adduct-induced DNA bend that allows binding of proteins which contain the high mobility group, HMG domain. Once the protein is bound to the DNA, it inserts a wedge-like phenyl group of phenylalanine 37 into the widened minor groove created by the bend. The tightly bound HMG protein causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, Cisplatin can be thought of as a monkey wrench in the DNA repair system. With the HMG protein bound to the DNA, the modified strand is not repaired properly and so the cell dies. The success of Cisplatin depends on its ratio of efficacy between cancerous and healthy cells.

The E.coli bacteria has claimed 14 lives and infected more than 300 hundred in the country. It has now spread to other European states.

Facing an increasing number of cases, German health authorities warned people to avoid eating raw cucumber, tomatoes and lettuce.

Reinhard Burger, President of Robert Koch Institute, said, "As for the present situation there is no reason to give the all-clear yet and it is possible the original source of the infection is still active and could lead to further infections."

The first cases of the EHEC outbreak were noticed in Northern Germany, but infections are now spreading across the country.

Cases haves spiked compared to other years, and are still rising.

Daniel Bahr, German Health Minister, said, "The result is that we unfortunately still have to prepare for a rising number of cases. Exercising caution is still recommended and we ask our citizens to be particularly careful. "

But, the German government says it's working around the clock to stop the outbreak and clarify how it arose.

Ilse Aigner, German Agriculture Minister, said, "Together, we face a big challenge to piece together hundreds or thousands of mosaic pieces from Germany and abroad into an overall picture that gives us a clear answer on how this terrible infection arose. "

In the meantime, experts are advising not to eat pre-packaged or prepared salad, which may contain the bacteria.

A video from the American Academy of Family Physicians

The lasting physical and emotional effects of a stroke can take a large toll on patients as well as family members with many stroke survivors needing to learn how to walk, talk and perform basic daily activities all over again.

Austin arm lift surgery (also commonly referred to as Brachioplasty) reduces excess skin and tissue from the under arm region, leaving the patient with smoother, more contoured arms. Visit http://www.austinplasticsurgery.com/body-contouring.php for more info.

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When it comes to our health men over the age of 45 are in need of regular doctor visits and testing, as a large percentage of medical decisions are based on the lab test results.

Dr. David L. Sneed discusses the Austin Threadlift procedure, commonly referred to as the non-surgical facelift. This minimally-invasive skin rejuvenation procedure uses non-absorbable sutures to gently lift and tighten sagging, facial tissue and drooping skin, while at the same time stimulating further collagen growth over time. If you would like to find out more about the Silhouette Suture ThreadLift procedure offered in Austin, TX, please visit http://www.amedspa.com/silhouette-threadlift.php

Jane Seymour sheds light on atrial fibrillation and AF-related stokes.

Achieving and maintaining long-term weight loss goals.

Brushing flossing and rinsing -the winning combination for preventing gingivitis

http://www.mediplus.co.uk A new and safer method of inserting a Foley catheter suprapubically. The technique allows the insertion to be carried out in an Outpatient setting, thus saving time, cost and effort. By using the Seldinger technique, the product reduces the chances of bowel or bladder perforation and resultant morbidity.
The product has been chosen by The NHS National Technology Adoption Centre to help facilitate adoption of the product.

Anatomy Tutorial During Trans

HD Hip Replacement Surgery

Carpal Tunnel Syndrome Ergonomics

HD High Definition Brain Surgery Medical Video

Laser Dental Surgery HD

Myocardial Infarction 3D Animation

Posterior Urethral Strictures Associated with Urinary Incontinence after Prostatectomy Management