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Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication. The mechanism involved in its activity against rheumatoid arthritis is not known.
Acute respiratory distress syndrome is characterised by rapid onset dyspnea, bilateral infiltrates on chest x-ray and respiratory failure. This may be due to conditions which directly affect the lung such as pneumonia, aspiration and near drowning. It may also be due to indirect lung injury, as in conditions like sepsis, pancreatitis, trauma and poisoning. The diagnostic criteria of ARDS, often described as the Berlin criteria is discussed in this presentation along with various management aspects of ARDS including ventilation strategies and use of antibiotics and diuretics. Finally prognostic features and alternative strategies are also discussed.
A detailed description of Adrenal insufficiency (Addison's disease) including basic physiology of the HPA axis, causes of primary and secondary insufficiency, clinical features of acute and chronic adrenal insufficiency. Lab testing for Addison's disease is also dealt with in detail. The management, both short term and long term are discussed in detail.
Shamika Burrage survived a near-fatal car accident two years ago, but not without losing something pretty important: her left ear. Now, thanks to a novel procedure performed at an Army medical center in Texas, Burrage is getting that ear back in a most unusual way. Plastic surgeons harvested cartilage from Burrage's ribs to create a new ear and then grew it under the skin of her forearm. Then the doctors at William Beaumont Army Medical Center in El Paso successfully transplanted the ear from her arm to her head. The technique -- a first time in the Army -- is called prelaminated forearm free flap, said Lt. Col. Owen Johnson III, chief of plastic and reconstructive surgery at William Beaumont Army Medical Center. Some of the big advantages of it is that it reduced the chance of more scarring around Burrage's ear. Also, growing the ear under the skin of her forearm allows new blood vessels to form. "(The ear) will have fresh arteries, fresh veins and even a fresh nerve so she'll be able to feel it," Johnson said on the US Army's website. Burrage, a 21-year-old private, still has to endure two more surgeries, but she's feeling more optimistic about the future than ever in the years since her accident. "It's been a long process for everything, but I'm back," said Burrage.
A vasectomy is one of the most effective kinds of birth control out there, and THE most effective method for people with penises and testicles. Vasectomies are almost 100% effective at preventing pregnancy — but not right away. It takes about 3 months for your semen to become sperm-free
In dark or dim light, the pupil dilates to allow more light into the eye to improve vision. Normal pupil size tends to range between 2.0 and 5.0 millimeters, depending on the lighting. The younger you are, the larger your pupils tend to be.
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An intrauterine device (IUD), also known as intrauterine contraceptive device (IUCD or ICD) or coil, is a small, often T-shaped birth control device that is inserted into a woman's uterus to prevent pregnancy. IUDs are one form of long-acting reversible birth control (LARC).
What are the classifications of burns? Burns are classified as first-, second-, or third-degree, depending on how deep and severe they penetrate the skin's surface. First-degree (superficial) burns. First-degree burns affect only the epidermis, or outer layer of skin. The burn site is red, painful, dry, and with no blisters. Mild sunburn is an example. Long-term tissue damage is rare and usually consists of an increase or decrease in the skin color. Second-degree (partial thickness) burns. Second-degree burns involve the epidermis and part of the dermis layer of skin. The burn site appears red, blistered, and may be swollen and painful. Third-degree (full thickness) burns. Third-degree burns destroy the epidermis and dermis and may go into the subcutaneous tissue. The burn site may appear white or charred Fourth degree burns. Fourth degree burns also damage the underlying bones, muscles, and tendons. There is no sensation in the area since the nerve endings are destroyed.
The oral contraceptive pill, commonly known as "the pill," is a hormone-based method of preventing pregnancy. It can also help resolve irregular menstruation, painful or heavy periods, endometriosis, acne, and premenstrual syndrome (PMS). Birth control pills work by preventing ovulation. No egg is produced, so there is nothing for the sperm to fertilize. Pregnancy cannot occur. "The pill" is used by nearly 16 percent of women aged 15 to 44 years in the United States, and it has both advantages and disadvantages. People with different risk factors may be advised to use a particular kind of pill. There are different types of contraceptive pills. They all contain synthetic forms of the hormones estrogen, progesterone, or both. Synthetic progesterone is called progestin. Combination pills contain progestin and estrogen. The "mini pill," contains only progestin. Monophasic pills all contain the same balance of hormones. With phasic pills, two or three different types of pill are taken each month, each with a different balance of hormones.
Treatment consists of diet modifications and laxatives A high-fiber diet can be effective, along with over-the-counter medications, such as stool softeners. In some cases, a medical procedure to remove the hemorrhoid may be needed to provide relief.
Tummy tuck surgery, also known as abdominoplasty, removes excess fat and skin and, in most cases, restores weakened or separated muscles creating an abdominal profile that is smoother and firmer. A flat and well-toned abdomen is something many of us strive for through exercise and weight control. Sometimes these methods cannot achieve our goals. Even individuals of otherwise normal body weight and proportion can develop an abdomen that protrudes or is loose and sagging. The most common causes of this include: Aging Heredity Pregnancy Prior surgery Significant fluctuations in weight What tummy tuck surgery can't do A tummy tuck is not a substitute for weight loss or an appropriate exercise program. Although the results of a tummy tuck are technically permanent, the positive outcome can be greatly diminished by significant fluctuations in your weight. For this reason, individuals who are planning substantial weight loss or women who may be considering future pregnancies would be advised to postpone a tummy tuck. A tummy tuck cannot correct stretch marks, although these may be removed or somewhat improved if they are located on the areas of excess skin that will be excised.
A fractured rib is usually a result of a fall or accident. Prolonged coughing and sports with repetitive movement, such as golf, also can cause a rib fracture. Symptoms include pain when taking a deep breath, pressing on the injured area, or bending or twisting the body. In most cases, fractured ribs usually heal on their own in one or two months. Pain relievers can make it easier to breathe deeply.
Ectopia cordis is a rare genetic defect. During a baby’s development in utero, their chest wall doesn’t form correctly. It also doesn’t fuse together as it normally would. This prevents the heart from developing where it should, leaving it defenseless and exposed outside of the protection of the chest wall. The defect affects about one in 126,000 births. In partial ectopia cordis, the heart is located outside the chest wall, but just under the skin. The heart can be seen beating through the skin.