Immunohistochemistry or IHC refers to the process of detecting antigens (e.g., proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues.[1] IHC takes its name from the roots "immuno," in reference to antibodies used in the procedure, and "histo," meaning tissue (compare to immunocytochemistry). Immunohistochemical staining is widely used in the diagnosis of abnormal cells such as those found in cancerous tumors. Specific molecular markers are characteristic of particular cellular events such as proliferation or cell death (apoptosis). IHC is also widely used in basic research to understand the distribution and localization of biomarkers and differentially expressed proteins in different parts of a biological tissue. Visualising an antibody-antigen interaction can be accomplished in a number of ways. In the most common instance, an antibody is conjugated to an enzyme, such as peroxidase, that can catalyse a colour-producing reaction. Alternatively, the antibody can also be tagged to a fluorophore, such as fluorescein or rhodamine

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High blood pressure and high cholesterol are the most common causes of these spasms. Approximately 2 percent of people with angina, or chest pain and pressure, experience coronary artery spasms. Coronary artery spasms can also occur in people who have atherosclerosis.

Paget's disease of the breast or Paget disease of the breast (/ˈpædʒᵻt/, rhymes with "gadget") (also known as Paget's disease of the nipple) is a malignant condition that outwardly may have the appearance of eczema, with skin changes involving the nipple of the breast.

The vertebrae are the bony building blocks of the spine. Between each of the largest parts (bodies) of the vertebrae are the discs. Ligaments are situated around the spine and discs. The spine has seven vertebrae in the neck (cervical vertebrae), 12 vertebrae in the mid-back (thoracic vertebrae), and five vertebrae in the low back (lumbar vertebrae). In addition, in the mid-buttock, beneath the fifth lumbar vertebra, is the sacrum, followed by the tailbone (coccyx).

Every 10 minutes, someone is added to the national transplant waiting list, and every day, 22 people on average die waiting for a match, according to the United Network for Organ Sharing. But, thanks to innovations in bioengineering, all of that could change. Conceived nearly 60 years ago, the total artificial heart (TAH) has helped sustain the sickest biventricular failure patients waiting for a transplant. While the design of the primary TAH used today has mostly remained stagnant since the ’80s, when it was first implanted in a patient, new models and clinical trials may lead to a better device and, one day, a permanent solution. “We are still many years away from that,” Dr. Nader Moazami, director of the Cardiac Transplantation and Ventricular Assist Device Therapy Program at the Cleveland Clinic, told FoxNews.com of a permanent artificial heart. “Although tremendous strides have been made, biocompatibility will always remain a challenge.”

Not every person who is missing a hand or upper limb might be eligible to receive a transplant. Many people are able to live full lives and accomplish everything they desire with the aid of a prosthetic device and sometimes without the aid of anything. However, some people find prosthetics difficult to use and the lack of sensory “feedback” from their prosthesis can significantly limit their function. These persons may consider reconstructive transplantation. We find that those patients who have either bilateral (both hands) amputations or those who have had their dominant hand amputated are likely to receive the most benefit from the procedure. However, we will provide information to any interested person regardless of the nature of their amputation.

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Head transplant successfully performed on monkey,

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You may have a lot of questions about epilepsy. We will help you understand the basics, answer the most common questions, and help you find resources and other information you may need. However, information alone won’t help you manage your epilepsy and find a way to cope with the effects on your daily life. You’ll need to learn how to use the information and make it work for you.

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Iatrogenic injury to the ureter is a potentially devastating complication of modern surgery. The ureters are most often injured in gynecologic, colorectal, and vascular pelvic surgery. There is also potential for considerable ureteral injury during endoscopic procedures for ureteric pathology such as tumor or lithiasis. While maneuvers such as perioperative stenting have been touted as a means to avoid ureteral injury, these techniques have not been adopted universally, and the available literature does not make a case for their routine use. Distal ureteral injuries are best managed with ureteroneocystostomy with or without a vesico-psoas hitch. Mid-ureteral and proximal ureteral injuries can potentially be managed with ureteroureterostomy. If the distal segment is unsuitable for anastomosis then a number of techniques are available for repair including a Boari tubularized bladder flap, transureteroureterostomy, or renal autotransplantation. In rare cases renal autotransplantation or ureteral substitution with gastrointestinal segments may be warranted to re-establish urinary tract continuity. Laparoscopic and minimally invasive techniques have been employed to remedy iatrogenic ureteral injuries.

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Toxoplasmosis (tok-so-plaz-MOE-sis) is a disease that results from infection with the Toxoplasma gondii parasite, one of the world's most common parasites. Toxoplasmosis may cause flu-like symptoms in some people, but most people affected never develop signs and symptoms. For infants born to infected mothers and for people with weakened immune systems, toxoplasmosis can cause extremely serious complications. If you're generally healthy, you probably won't need any treatment for toxoplasmosis. If you are pregnant or have lowered immunity, certain medications can help reduce the infection's severity. The best approach, though, is prevention.

Allergic bronchopulmonary aspergillosis (ABPA) is a condition characterised by an exaggerated response of the immune system (a hypersensitivity response) to the fungus Aspergillus (most commonly Aspergillus fumigatus). It occurs most often in patients with asthma or cystic fibrosis.