Sickle cell anemia causes pain, fatigue and delayed growth, all because of a lack of enough healthy red blood cells. And yet genetic mutations that cause it — recessive genes for the oxygen-carrying hemoglobin protein — have survived natural selection because they also seem to provide a natural defense against malaria.

Sickle cell anemia is an inherited form of anemia: This is a condition in which there aren't enough healthy red blood cells to carry adequate oxygen throughout your body. Normally, your red blood cells are flexible and round, moving easily through your blood vessels. In sickle cell anemia, the red blood cells become rigid and sticky and are shaped like sickles or crescent moons. These irregularly shaped cells can get stuck in small blood vessels, which can slow or block blood flow and oxygen to parts of the body. There's no cure for most people with sickle cell anemia. However, treatments can relieve pain and help prevent further problems associated with sickle cell anemia.

When is endoscopy used? Endoscopes were first developed to look at parts of the body that couldn’t be seen any other way. This is still a common reason to use them, but endoscopy now has many other uses too. It’s often used in the prevention, early detection, diagnosis, staging, and treatment of cancer. To prevent and screen for cancer Some types of endoscopes are used to look for cancer in people who have no symptoms. For example, colonoscopy (KO-lun-AH-skuh-pee) and sigmoidoscopy (SIG-moid-AH-skuh-pee) are used to screen for colon and rectal cancer. These procedures can also help prevent cancer because they let doctors find and remove polyps (growths) that might become cancer if left alone. To find cancer early Endoscopy can sometimes be used to find cancer early, before it has had a chance to grow or spread. Looking for causes of symptoms When people go to the doctor with certain symptoms, endoscopy can sometimes be used to help find a cause. For instance: Laryngoscopy to look at the vocal cords in people with long-term hoarseness Upper endoscopy in people having trouble swallowing Colonoscopy in people with anemia (low red blood cell counts) with an unknown cause Colonoscopy in people with blood in their stool Looking at problems found on imaging tests Imaging tests such as x-rays and CT scans can sometimes show physical changes within the body. But these tests may only give information about the size, shape, and location of the problem. Doctors use endoscopes to see more details, like color and surface texture, when trying to find out what’s going on. Newer methods of endoscopy that include high magnification are being tested to find out whether they are more useful in detecting cancer and other abnormal cells on the inner surfaces of the body. To diagnose and find out the stage (extent) of cancer To get a tissue sample Going one step further, most types of endoscopes have tools on the end that the doctor can use to take out small tissue samples. This procedure is called a biopsy (BY-op-see). Samples can be taken from suspicious areas and then looked at under a microscope or tested in other ways to see if cancer is there. A biopsy is usually the best way to find out if a growth or change is cancer or something else. Getting a closer look In some cases endoscopes are used to help find out how far a cancer has spread. Thoracoscopy (THOR-uh-KAHS -kuh-pee) and laparoscopy (LAP-uh-RAHS-kuh-pee) can be very useful in finding out if cancer has spread into the thorax (chest) or abdomen (belly). The surgeon can look into these places making only a small incision (cut) in the skin.

Every 10 minutes, someone is added to the national transplant waiting list, and every day, 22 people on average die waiting for a match, according to the United Network for Organ Sharing. But, thanks to innovations in bioengineering, all of that could change. Conceived nearly 60 years ago, the total artificial heart (TAH) has helped sustain the sickest biventricular failure patients waiting for a transplant. While the design of the primary TAH used today has mostly remained stagnant since the ’80s, when it was first implanted in a patient, new models and clinical trials may lead to a better device and, one day, a permanent solution. “We are still many years away from that,” Dr. Nader Moazami, director of the Cardiac Transplantation and Ventricular Assist Device Therapy Program at the Cleveland Clinic, told FoxNews.com of a permanent artificial heart. “Although tremendous strides have been made, biocompatibility will always remain a challenge.”

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Four-Step Guide to ABG Analysis Is the pH normal, acidotic or alkalotic? Are the pCO2 or HCO3 abnormal? Which one appears to influence the pH? If both the pCO2 and HCO3 are abnormal, the one which deviates most from the norm is most likely causing an abnormal pH. Check the pO2. Is the patient hypoxic?

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They were victims of caisson disease. This condition, also known as the bends or decompression sickness, is caused by the formation of gas bubbles in the body. Human body tissues contain small amounts of the gases present in the air.

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One of the criteria to determine brain death is the irreversible absence of cerebral and brainstem reflexes including pupillary, oculocephalic, oculovestibular (caloric), corneal, gag, sucking, swallowing, and extensor posturing. Some of the other criteria for determination of brain death include: 1. Absence of respiratory drive (apnea) off the ventilator for a duration that is sufficient to produce hypercarbic drive (usually 10 to 20 minutes to achieve pC02 of 50 to 60 mmHg) ( 2. Body temperature below 34 C (93.2 F) 3. EEG isoelectric for 30 minutes at maximal gain 4. Absence of cerebral circulation by Doppler or magnetic resonance angiography 5. At least 24 hours of observation in adults with anoxic-ischemic brain damage with a negative drug screen

Ebstein anomaly is a congenital malformation of the heart that is characterized by apical displacement of the septal and posterior tricuspid valve leaflets, leading to atrialization of the right ventricle with a variable degree of malformation and displacement of the anterior leaflet.

Orthognathic surgery presented in this video in order of appearance. 1. Advancement Genioplasty 2. Maxillary Advancement 3. Maxillary impaction 4. BSSO Mandibular Advancement 5. BSSO Mandibular Set-back 6. Maxillary Posterior Impaction

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Broca's Aphasia (expressive) When a stroke injures the frontal regions of the left hemisphere, different kinds of language problems can occur. This part of the brain is important for putting words together to form complete sentences. Injury to the left frontal area can lead to what is called Broca's aphasia.