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Part 2: Translational Neuroscience of Excessive Daytime Sleepiness (EDS), Fatigue and Hype
Part 2: Translational Neuroscience of Excessive Daytime Sleepiness (EDS), Fatigue and Hype Mohammad Torabi Nami 8,882 Views • 2 years ago

Sleepiness, tiredness and fatigue are complaints which must be thoroughly analyzed to eliminate blur and ambiguity.
Physiological sleepiness (“sleep pressure”) increases while being awake and additionally underlies the circadian rhythm with a lower threshold to fall asleep during night time.
Excessive daytime sleepiness (EDS) is considered normal only after sleep deprivation. Clinically, EDS manifests by frequents daytime napping and/or reduced alertness with automatic behavior or - in its extreme form - in recurrent attacks of sudden, uncontrollable compulsion to sleep also in inappropriate situations (= “sleep attacks”).
EDS is “objectively” addressed by measuring the mean sleep latency to four to five nap opportunities throughout the day using the multiple sleep latency test (MSLT) or the maintenance of wakefulness test (MWT).
EDS denotes both, a ready entrance into sleep as well as difficulty in staying awake during daytime or accordingly in inappropriate situations. These two partially independent aspects of EDS are separately assessed by the “passive” MSLT and the “active” MWT respectively.
For that reason the MSLT and MWT only weakly correlate with each other when tested over a broad range of patients with EDS. It is important to keep in mind, that these tests are importantly influenced by a great variety of factors such as mood, anxiety, and motivation.
“Vigilance” comprises wakefulness, alertness and attention and therefore is more than just the reciprocal to sleepiness. Cognitive performance tasks such as Steer Clear Reaction Time Test (SCRTT) or driving simulators require the complete integrity of vigilance to achieve normal results. Hypersomnia is usually broadly defined as the combination of abnormally prolonged night-time sleep (regularly >10 h) with EDS during ≥1 months.
On the other hand, the term hypersomnia has also been used in a narrower scene for the isolated abnormality of a prolonged night-time sleep need (>10 h). “Tiredness”, also in colloquial language often used for sleepiness, in a broader sense also describes the feeling of lack of energy, motivation and initiative.

These patients seek rest rather than sleep. They often cannot fall asleep when given the opportunity in spite of feeling tired, and hence, in an MSLT, do not show an abnormally short sleep latency. Furthermore, tiredness (and fatigue) as opposed to sleepiness has a mental (“central”) and physiological (bodily or “peripheral”) component, which the patients can readily distinguish. Patients with insomnia, mild sleep apnea syndrome, or depression rather suffer from mental tiredness than sleepiness during the day.
The simple subjective self-assessment using the Epworth Sleepiness Scale (ESS) quite reliably differentiates between sleepiness and mental tiredness (without sleepiness), which makes it a widely used test. The term “fatigue” is also heterogeneously used.
In physiology the “fatigue” implied a “time on task performance decrement” to describe decreasing muscle force during a sustained physical effort. In clinical medicine one distinguishes physical (“peripheral”) from mental (“central”) fatigue and the term usually denotes a chronic and more abnormal situation than tiredness.
In a broad sense “fatigue” implies a deficiency in coping satisfactorily with mental and physical work load. The chronic fatigue syndrome entails both mental as well as a physical fatigue (so called “leaden paralysis” of limbs). Depressive states are often associated with insomnia and fatigue, but there are also cases with hypersomnia rather than insomnia ( non organic hypersomnia , “atypical depression” or “hypersomnolent depression”)
Sometimes these patients have a tendency to spend much of the day lying in the bed without actually sleeping (so called clinophilia). The basic and clinical aspects of fatigu

Tampa DUI Lawyers
Tampa DUI Lawyers Ashley Noel 5,293 Views • 2 years ago

Tampa DUI Lawyers are dedicated to help DUI offendes fight their case. They are always expected to deal the situation properly and guide their clients on right steps and ways they should take.

Diverticulitis Attack Surgery
Diverticulitis Attack Surgery Surgeon 8,758 Views • 2 years ago

Diverticulitis Attack Surgery

Uterine artery ligation
Uterine artery ligation maronesc 11,881 Views • 2 years ago

Uterine artery ligation during a C-Section

Management of Acne (Part - 1)
Management of Acne (Part - 1) Manuscriptedit 4,146 Views • 2 years ago

Acne, or acne vulgaris, is a skin problem that starts when oil and dead skin cells clog up your pores. Some people call it blackheads, blemishes, whiteheads, pimples, or zits. Check out the video for detailed research study on Acne vulgaris and provide us feedbacks. Please subscribe for regular updates...............

Treating Uterine Fibroids
Treating Uterine Fibroids Info4YourLife 4,950 Views • 2 years ago

Uterine fibroids are the most common benign tumors and can affect one in three in Canada. While most fibroids are asymptomatic, they can cause heavy and painful periods, urinary frequency and urgency and pelvic discomfort and pain. A new treatment is available that doesn’t involve invasive surgery. With Fibristal, you can treat fibroids, relieve symptoms and finally live your life the way you want to!

Chest x-ray for beginners
Chest x-ray for beginners Magdy 1,270 Views • 2 years ago

This video is a simplified tutorial to teach how to read and understand chaest x-rays. It is for beginners

Toilet Phobia Cure Bathroom Anxiety - Phobia Of Public Toilets, How To Overcome Shy Bladde
Toilet Phobia Cure Bathroom Anxiety - Phobia Of Public Toilets, How To Overcome Shy Bladde lorenzo 6,052 Views • 2 years ago

Toilet Phobia Cure Bathroom Anxiety Phobia Of Public Toilets, Paruresis Shy Bladder.
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Mitral Valve Repair video
Mitral Valve Repair video Mohamed Ibrahim 869 Views • 2 years ago

Mitral Valve Repair video

Stages Of Human Creation in the Qur'an of more than 1,400 years
Stages Of Human Creation in the Qur'an of more than 1,400 years Ahmed Sobhy 4,715 Views • 2 years ago

Quran describes the stages of human creation accurately

Evaluacion de la microcirculacion con SDF (Sidestream dark field) Mi
Evaluacion de la microcirculacion con SDF (Sidestream dark field) Mi Ricardo Yanez 1,586 Views • 2 years ago

Evaluación de la microcirculación con SDF (Sidestream dark field) Microscan® como método de monitorización no invasiva en microcirugía.

Pain In The Gut
Pain In The Gut Kevin Anderson 3,971 Views • 2 years ago

Ulcerative Colitis is a painful disease that affects over 100,000 Canadians.

Carpal Tunnel Release Procedure
Carpal Tunnel Release Procedure Surgeon 57,976 Views • 2 years ago

Carpal tunnel surgery, also called carpal tunnel release (CTR) and carpal tunnel decompression surgery, is a surgery in which the transverse carpal ligament is divided. It is a treatment for carpal tunnel syndrome and recommended when there is static (constant, not just intermittent) numbness, muscle weakness, or atrophy, and when night-splinting no longer controls intermittent symptoms of pain in the carpal tunnel. In general, milder cases can be controlled for months to years, but severe cases are unrelenting symptomatically and are likely to result in surgical treatment.

Impressive: A Surgery on a Horse
Impressive: A Surgery on a Horse Surgeon 6,280 Views • 2 years ago

Have you watched a surgery on a horse before?

Traumatic Acute Subdural Hematoma
Traumatic Acute Subdural Hematoma Surgeon 7,063 Views • 2 years ago

A subdural hematoma (SDH) is a collection of blood below the inner layer of the dura but external to the brain and arachnoid membrane (see the images below). Subdural hematoma is the most common type of traumatic intracranial mass lesion. Subdural hematoma occurs not only in patients with severe head injury but also in patients with less severe head injuries, particularly those who are elderly or who are receiving anticoagulants. Subdural hematoma may also be spontaneous or caused by a procedure, such as a lumbar puncture (see Etiology). Rates of mortality and morbidity can be high, even with the best medical and neurosurgical care (see Prognosis). Subdural hematomas are usually characterized on the basis of their size and location and the amount of time elapsed since the inciting event age (ie, whether they are acute, subacute, or chronic). When the inciting event is unknown, the appearance of the hematoma on neuroimaging studies can help determine when the hematoma occurred. These factors, as well as the neurologic and medical condition of the patient, determine the course of treatment and may also influence the outcome. Generally, acute subdural hematomas are less than 72 hours old and are hyperdense compared with the brain on computed tomography scans. The subacute phase begins 3-7 days after acute injury. Chronic subdural hematomas develop over the course of weeks and are hypodense compared with the brain. However, subdural hematomas may be mixed in nature, such as when acute bleeding has occurred into a chronic subdural hematoma. Presentation varies widely in acute subdural hematoma (see Clinical). Many of these patients are comatose on admission. However, approximately 50% of patients with head injuries who require emergency neurosurgery present with head injuries that are classified as moderate or mild (Glasgow Coma Scale scores 9-13 and 14-15, respectively). Many of these patients harbor intracranial mass lesions. In a large series of patients who developed intracranial hematomas requiring emergent decompression, more than half had lucid intervals and were able to make conversation between the time of their injury and subsequent deterioration. In a more comprehensive review of the literature on the surgical treatment of acute subdural hematomas, lucid intervals were noted in up to 38% of cases. These patients may be more likely to benefit from medical and surgical intervention when instituted in a timely fashion (ie, before further neurological deterioration).

Hair Transplant Surgery
Hair Transplant Surgery Alicia Berger 14,220 Views • 2 years ago

The hair transplant surgeon can accurately estimate the number of follicular grafts that can be obtained from dissecting a donor strip of a given size. The same number of follicular units can be used to cover a specific size bald area regardless of the patient's actual hair density.

11 Steps to Read an ECG ( EKG )
11 Steps to Read an ECG ( EKG ) samer kareem 12,052 Views • 2 years ago

ECG Learn it

Vesicoureteral Reflux Education Video
Vesicoureteral Reflux Education Video samer kareem 1,646 Views • 2 years ago

Vesicoureteral (ves-ih-koe-yoo-REE-tur-ul) reflux is the abnormal flow of urine from your bladder back up the tubes (ureters) that connect your kidneys to your bladder. Normally, urine flows only down from your kidneys to your bladder. Vesicoureteral reflux is usually diagnosed in infants and children. The disorder increases the risk of urinary tract infections, which, if left untreated, can lead to kidney damage. Vesicoureteral reflux can be primary or secondary. Children with primary vesicoureteral reflux are born with a defect in the valve that normally prevents urine from flowing backward from the bladder into the ureters. Secondary vesicoureteral reflux is due to a urinary tract malfunction, often caused by infection. Children may outgrow primary vesicoureteral reflux. Treatment, which includes medication or surgery, aims at preventing kidney damage.

Hyperthyroidism
Hyperthyroidism samer kareem 2,963 Views • 2 years ago

Graves disease is an autoimmune disorder that leads to an overactive thyroid gland (hyperthyroidism). An autoimmune disorder is a condition that occurs when the immune system mistakenly attacks healthy tissue. Causes The thyroid gland is an important organ of the endocrine system. The gland is located at the front of the neck above where the collarbones meet. This gland releases the hormones thyroxine (T4) and triiodothyronine (T3), which control body metabolism. Controlling metabolism is important for regulating mood, weight, and mental and physical energy levels. When the body makes too much thyroid hormone, the condition is called hyperthyroidism. (An underactive thyroid leads to hypothyroidism.) Graves disease is the most common cause of hyperthyroidism. It is due to an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormone. Graves disease is most common in women over age 20. But the disorder can occur at any age and can affect men as well. Symptoms Younger people may have these symptoms: Anxiety or nervousness, as well as problems sleeping Breast enlargement in men (possible) Problems concentrating Fatigue Frequent bowel movements Hair loss Heat intolerance and increased sweating Increased appetite, despite having weight loss Irregular menstrual periods in women Muscle weakness of the hips and shoulders Moodiness, including irritability and anger Rapid or irregular heartbeat Shortness of breath with activity Tremor Many people with Graves disease have problems with their eyes: The eyeballs may seem to be bulging out and may be painful. Eyes can feel irritated and be tearing. Double vision may be present. Older people may have these symptoms: Rapid or irregular heartbeat Chest pain Memory loss Weakness and fatigue

Patient Stupidly Defibrillates Herself
Patient Stupidly Defibrillates Herself samer kareem 2,135 Views • 2 years ago

The key difference between monophasic and biphasic defibrillator is that the monophasic defibrillator is a type of defibrillation waveform where a shock is delivered to the heart from one vector as shown below. Whereas, in biphasic defibrillation, shock is delivered to the heart via two vectors.

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