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HCC-Ain Shams Clinic video showing percutaneous RFA from ainshams university. A case of male patient 70 years old, He is complaining of a pain in the right hypochondrium of 6 months duration, The patient is a known case of chronic liver disease, He had an attack of hematemesis 2 years ago, Upper GIT Endoscopy was performed and esopageal varices were revealed and were injected by a sclerosing material.
DOING LESS BUT BRAINY DESCRIBES A NEW GENERATION OF IMMEDIATE ZIRCONIA IMPLANTS ANATOMICAL AND CUSTOM-MADE. YOUR DENTAL ROOT IS MILLED IN ZIRCONIA AND IN 20 SECONDS SEATED, NO DRILLING, NO AUGMENTATION, NO MEMBRANES, FLAPLESS, NO 3D PLANNING, NO CAD/CAM SPLINTS OR GUIDED SURGERY REQUIRED! EASY AND CONSEQUENTIAL SYSTEM. NO MORE INCONGRUOUS AND UGLY SILVER-COLORED TITANIUM IMPLANTS IN TIME CONSUMING, PAINFUL AND COSTLY PROCEDURES. IT`S HIGH TIME TO RESPECT THE ANATOMY NOT ALTER IT BY DRILLING AND AUGMENTATION. BIOIMPLANT
FROM INDUSTRY RECRUITED DENTAL EXPERTS REMAIN SPEECHLESS AND IGNORANT SINCE YEARS. THESE MEDICAL PROFESSIONALS PREFERE TO MAKE MULTIPE WEARING AND COSTLY INTERVENTIONS INSTEAD OFJOINING AND MAKING RESEARCH ON THIS SIMPLE AND STRAIGHTFORWARD METHOD FOR THE BENEFIT OF THEIR PATIENTS. THERE IS NO ETHICS IN THIS BUSINESS JUST MAKING MONEY!
HISTORY WILL MAKE A JUDGEMENT ON THESE DENTALCOMMUNITIES NOT CARING FOR THEIR PATIENTS AND SCIENCE.
Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target guanines. Cisplatin can bond more tightly with nitrogen because nitrogen balances the platinum charge more effectively than chlorine. It is this adduct-induced DNA bend that allows binding of proteins which contain the high mobility group, HMG domain. Once the protein is bound to the DNA, it inserts a wedge-like phenyl group of phenylalanine 37 into the widened minor groove created by the bend. The tightly bound HMG protein causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, Cisplatin can be thought of as a monkey wrench in the DNA repair system. With the HMG protein bound to the DNA, the modified strand is not repaired properly and so the cell dies. The success of Cisplatin depends on its ratio of efficacy between cancerous and healthy cells.