Gross Tooth extraction ( For root removal )

Triplet C-section

The pathobiology of MM is complex and the root underlying cause of myeloma is the multistep genetic changes in the postgerminal center B cell. In addition, the bone marrow microenvironment plays a crucial role.[2] The interaction between myeloma cells and the microenvironment is mediated through adhesive interactions via cell-surface receptors, paracrine loops involving several cytokines, such as IL-6, VEGF and IL-10, and suppression of cell-mediated immunity.[2–4] IMiDs modulate many of these interactions leading to decreased myeloma cell growth and survival. Thalidomide was the first IMiD introduced to treat MM. It was initially synthesized in Germany in the late 1950s to treat insomnia and morning sickness. It was withdrawn from the market in 1961 because of its teratogenic effects. Its immunomodulatory properties were realized when it was observed to improve erythema nodosum leprosum, a painful immunologic reaction of leprosy, leading to its approval by the FDA in 1998 with tight prescribing and marketing regulations. Subsequent research showed the diverse mechanism of action of thalidomide including its immunomodulatory effect by inhibition of de novo IgM antibody synthesis,[5] modulation of the T-cell subset by increasing the T-helper cells, inhibitory effects on the TNF-α and antiangiogenic activity leading to its use in MM. Significantly higher response rates in combination with dexamethasone led to its approval in the treatment of newly diagnosed MM in 2006. Lenalidomide, a second-generation IMiD, was developed from the structural backbone of the thalidomide molecule by the addition of an amino group (NH2-) at position 4 of the phthaloyl ring and removal of the carbonyl group (C = O) of the 4-amino-substituted phthaloyl ring (Table 1).[6] In addition to immunomodulatory effects, other mechanisms of action have been described such as direct cytotoxicity via induction of apoptosis, inhibition of cell adhesion molecules and inhibition of growth signals that promote bone marrow angiogenesis

There are three main types of lung cancer. Knowing which type you have is important because it affects your treatment options and your outlook (prognosis). If you aren’t sure which type of lung cancer you have, ask your doctor so you can get the right information.

There is nothing that compares to the fresh-faced feeling you have when you leave the aesthetician after a facial. There is just something so freeing about knowing that nasty little buggers like blackheads, whiteheads and all other kinds of heads have been given the heave-ho. That could be why this Facebook video of a blackhead being removed has gone viral. With more than 24 million views, the popular video is weirdly difficult to stop watching.

wisdom teeth removal - surgery,extraction

Ovarian dermoid cyst and mature cystic ovarian teratoma are terms often used interchangeably to refer to the most common ovarian neoplasm. These slow-growing tumours contain elements from multiple germ cell layers and are best assessed with ultrasound.

finger pulp abscess drainage EXPLOSION of pus

Lip Ring Stuck procedure

But here's the good news: it is possible to prevent prediabetes from developing into type 2 diabetes. Eating healthy food, losing weight and staying at a healthy weight, and being physically active can help you bring your blood glucose level back into the normal range.

A small spontaneous pneumothorax may resolve without treatment; a pneumothorax arising as a result of lung disease or injury requires immediate treatment. Treatment may include insertion of a chest tube or aspiration of the free air in the chest cavity.

it takes about 1-2 hours. First, the orthodontist will thoroughly clean and dry your teeth. Next, he or she will apply the bonding glue to your teeth and...

New MitraClip procedureMitral valve regurgitation, known as leaky heart valve, can be treated with the MitraClip procedure,

Surgical Repair of Pectus Excavatum. Pectus excavatum is a condition in which a person's breastbone is sunken into his or her chest.

3D animation video of Varicose Veins Sclerotherapy Treatment

Skin isn't just your body's biggest organ-- it's also the fastest growing.

GIANT EAR WAX REMOVAL By using the elephant ear device.It's very useful video for medical students.Please share it!

VR medical training takes you inside the human body.

A patient suffering from Diabetic gangrene and maneged by "myiasis"

This device could save thousands of lives from heart failure.