The Closure Procedure for Varicose Veins is a clinically proven, minimally invasive procedure that treats varicose veins and their underlying cause, venous reflux, with little or no pain. Closure patients can walk away from the vein procedure and be back to everyday activities – either at home or at work – typically within a day.

HCC-Ain Shams Clinic video showing percutaneous RFA from ainshams university. A case of male patient 70 years old, He is complaining of a pain in the right hypochondrium of 6 months duration, The patient is a known case of chronic liver disease, He had an attack of hematemesis 2 years ago, Upper GIT Endoscopy was performed and esopageal varices were revealed and were injected by a sclerosing material.

Health Care Reform Cost Visualization

A video discussing the treatment of Acne with LASER

MPG Video for purpose

Revision knee replacement video shows approach and removal of components.

Left pleura rupture during laparoscopy

Toxin is a protein produced by the bacterium Clostridium botulinum, and is extremely neurotoxic.

Good surgery

Unedited Cataract Surgery 3

Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target guanines. Cisplatin can bond more tightly with nitrogen because nitrogen balances the platinum charge more effectively than chlorine. It is this adduct-induced DNA bend that allows binding of proteins which contain the high mobility group, HMG domain. Once the protein is bound to the DNA, it inserts a wedge-like phenyl group of phenylalanine 37 into the widened minor groove created by the bend. The tightly bound HMG protein causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, Cisplatin can be thought of as a monkey wrench in the DNA repair system. With the HMG protein bound to the DNA, the modified strand is not repaired properly and so the cell dies. The success of Cisplatin depends on its ratio of efficacy between cancerous and healthy cells.

More videos on my youtube channel

Histology of Tongue Circumvallate Papilla

Histology of Blood Smear

Histology of Parathyroid

Drugs Through a Saline Lock

Drawing Blood Sample Venipuncture

Staff Communication and Interaction

Methotrexate Metabolism and rheumatoid arthritis

Stroke Animation 3D