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Osteoarthritis is a degenerative joint disease that is caused by the chronic breakdown and eventual loss of cartilage within the joints. As the cartilage wears away, the bones that meet at the joint begin to rub against each other. This can cause extreme pain and can severely reduce movement and flexibility of the joint. Growths of bone, called bone spurs, can also form around the edges of the joint and cause pain. Joint swelling can also occur if the synovial membrane lining the joint becomes irritated, producing excess fluid that collects inside the joint. What Causes Osteoarthritis? More than half of the population age 65 or older have osteoarthritis in at least one joint. Osteoarthritis usually results from injury to a joint or from wear and tear over time. Heredity, lack of use, and being overweight also contribute to the development of osteoarthritis. Treating Osteoarthritis Treatment can include weight loss, physiotherapy, and medication. If the condition becomes severe and mobility is greatly reduced, hip replacement surgery may be necessary.

Ischemic colitis occurs when blood flow to part of the large intestine (colon) is reduced, usually due to narrowed or blocked blood vessels (arteries). The diminished blood flow doesn't provide enough oxygen for the cells in your digestive system. Ischemic colitis can cause pain and may damage your colon. Any part of the colon can be affected, but ischemic colitis usually causes pain on the left side of the belly area (abdomen). The condition can be misdiagnosed because it can easily be confused with other digestive problems. Ischemic colitis may heal on its own. But you may need medication to treat ischemic colitis or prevent infection, or you may need surgery if your colon has been damaged. Symptoms ShareTweet Oct. 13, 2015 References Products and Services Newsletter: Mayo Clinic Health Letter See also Abdominal pain Colonoscopy Color Blue Detects Colon Cancer CT scan CT scans: Are they safe? Diarrhea Ultrasound Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship PolicyOpportunitiesAd Choices Mayo Clinic Store Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. NEW! – The Mayo Clinic Diet, Second Edition Treatment Strategies for Arthritis Mayo Clinic on Better Hearing and Balance Keeping your bones healthy and strong The Mayo Clinic Diet Online Ads by Swoop Psoriasis Treatment www.informationaboutpsoriasis.com Explore a Treatment Option for Moderate to Severe Plaque Psoriasis Immune Biomarker PD-L1 - Discover the Science iobiomarkers.bmsinformation.com Understanding Assay Results for PD-L1 is Crucial for Treatment Decisions. Biomarker PD-L1 Information - Easy to Download Resources iobiomarkers.bmsinformation.com Explore the Role of PD-L1 in Immuno-Oncology & the Evolving Biomarker Landscape.

Thoracic Epidural Placement Paramedian Approach

Varicose veins are caused by weakened valves and veins in your legs. Normally, one-way valves in your veins keep blood flowing from your legs up toward your heart. When these valves do not work as they should, blood collects in your legs, and pressure builds up. The veins become weak, large, and twisted.

An unnamed Russian scientist has introduced the concept of a device that attaches to the wall of the artery. It would first stop blood flow to the area to prevent breakaway plaque. A drill would then scrape the plaque from the artery wall. The procedure of treating plaque buildup could include bypass surgery, stent replacement and balloon angioplasty. Since the plaques are of different types and locations in the body, the inventor proposed using different types of cutting mills.

Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target guanines. Cisplatin can bond more tightly with nitrogen because nitrogen balances the platinum charge more effectively than chlorine. It is this adduct-induced DNA bend that allows binding of proteins which contain the high mobility group, HMG domain. Once the protein is bound to the DNA, it inserts a wedge-like phenyl group of phenylalanine 37 into the widened minor groove created by the bend. The tightly bound HMG protein causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, Cisplatin can be thought of as a monkey wrench in the DNA repair system. With the HMG protein bound to the DNA, the modified strand is not repaired properly and so the cell dies. The success of Cisplatin depends on its ratio of efficacy between cancerous and healthy cells.

Commentary:

0:24
He may not look like he’s in good condition but you can guesst that his somewhere in nirvana at this point
0:44
After the operation, this patient loses more than just color in his skin but apparently he loses his nipples as well
1:43
This sedated patient is equipped with his own hand-gun. No pun intended
2:17
His anesthesia dose came with the usual side effects of crazy talk with a dash of attitude and sarcasm
3:17
The only thing crazier than love is being sedated during an endometriosis surgery
4:36
This may come as a surprise to some but penguins don’t actually reside in Alaska. In case you didn’t know that well now you do
5:09
If the doctor advises you against something you can’t resist doing, how many of us would still listen to him?
6:35
When them meds start kicking in , it’s time to frame this experience as an excuse to divulge some of your secret fantasies
7:05
There’s a time and place dirty jokes but anesthesia told this guy any times the right time
7:24
Her 16 year old son talks about the last thing he remembers right after surgery and this is what he says
8:35
She’s definitely not in the mood at all. I wouldn’t wanna tick her off during this time if I were you
8:44
A feeling of relief after your operation may be followed by some emotional changes such as mood swings and over sensitivity
9:44
Even if you do say something you wouldn't normally say while you are under sedation, according to some doctors, “it's always kept within the operating room”
10:38
The beeping sounds of the medical equipments tip this patient over the edge. so she tries to drown out the noise with her own voice
11:08
Anyone who's received anesthesia can attest to feeling pretty loopy. Although many won't remember it's fairly common to say some wacky things after waking up
11:53
It's typical for people to feel sad or vulnerable after surgery. Kind of like how this girl is feeling right now
12:04
If she wasn’t under the influence in the hospital right now , it would be pretty hard to justify this type of behavior
12:17
Imagine working as an anesthesiologist. You might become numb to a lot of strange behaviors and everything unusual becomes the new norm for you

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Transmetatarsal Amputation for Gangrene

The best sleep position during pregnancy is “SOS” (sleep on side). Even better is to sleep on your left side. Sleeping on your left side will increase the amount of blood and nutrients that reach the placenta and your baby. Keep your legs and knees bent, and put a pillow between your legs.

In dark or dim light, the pupil dilates to allow more light into the eye to improve vision. Normal pupil size tends to range between 2.0 and 5.0 millimeters, depending on the lighting. The younger you are, the larger your pupils tend to be.

The procedure was performed under wrist block regional anesthesia with tourniquet control. A single Chinese finger trap was used on the thumb with 5 to 8 lb of ongitudinal traction. The arm was held down with wide tape around the tourniquet securing it to the hand table to serve as countertraction. A shoulder holder, rather than a traction tower, was used to facilitate fluoroscopic intervention more easily. The Trapeziometacarpal joint was detected by palpation. Joint distension was achieved by injecting 1 to 3 mL of normal saline (Fig. 1). It is important to distally direct the needle approximately 20 degrees to clear the dorsal flare of the metacarpal base and enter the joint capsule. This course should be reproduced upon entering with arthroscopic sleeve/ trocar assembly to minimize iatrogenic cartilage injury. Fluid distention is important to facilitate this. The incision for the 1-R (radial) portal, used for proper assessment of the dorsoradial ligament, posterior oblique ligament, and ulnar collateral ligament, was placed just volar to the abductor pollicis longus tendon. The incision for the 1-U (ulnar) portal, for better evaluation of the anterior oblique ligament and ulnar collateral ligament, was made just ulnar to the extensor pollicis brevis tendon. A short-barrel, 1.9-mm, 30- degree inclination arthroscope was used for complete visualization of the CMC joint surfaces, capsule, and ligaments, and then appropriate management was done, as dictated by the stage of the arthritis detected (Fig. 2A). A full-radius mechanical shaver with suction was used in all the cases, particularly for initial debridement and visualization. Most of the cases were augmented with radiofrequency ablation to perform a thorough synovectomy and radiofrequency was also used to perform chondroplasty in the cases with focal articular cartilage wear or fibrillation. Chondroplasty refers to thedebridement of the fibrillated cartilage to improve vascularity of the cartilage and enhance the growth of fibrocartilage. Ligamentous laxity and capsular attenu- ation were treated with thermal capsulorraphy using a radiofrequency shrinkage probe. We were careful to avoid thermal necrosis; hence, a striping technique was used to tighten the capsule of the lax joints. The striping technique refers to thermal shrinkage performed in longitudinal stripes on the lax capsule, so as to leave vascular zones between the stripes; hence, thermal necrosis is prevented. Arthroscopic stage I disease was characterized by synovitis without any cartilage wear, wherein a synovectomy coupled with thermal capsulor- raphy as described was performed.

The shoulder joint is formed where the humerus (upper arm bone) fits into the scapula (shoulder blade), like a ball and socket. Other important bones in the shoulder include: The acromion is a bony projection off the scapula. The clavicle (collarbone) meets the acromion in the acromioclavicular joint.

Very small currents can be imperceptible. Larger current passing through the body may make it impossible for a shock victim to let go of an energized object. Still larger currents can cause fibrillation of the heart and damage to tissues. Death caused by an electric shock is called electrocution.

Hypoglycemia is a common and serious medical emergency which may occur in both daibetic and non-diabetic patients. The signs and symptoms of hypoglycaemia may be present in many individuals, but may also be masked in several individuals due to a condition called hypoglycaemia induced autonomic failure. This presentation aims to deal with the causes, clinical features, diagnosis and management of various causes of hypoglycaemia. The causes of hypoglycaemia may be divided into hypoglycaemia in ill or medicated individuals and hypoglycaemia in previously asymptomatic individuals. A variety of causes are discussed under both headings. Management of hypoglycaemia is also discussed in detail. There is also a brief discussion about management of insulinoma.

Thanks to a new, state-of-the-art procedure for total knee replacement developed by surgeons at the Detroit Medical Center's Sinai-Grace Hospital, the rehabilitation time for patients has been reduced from six months to six weeks. ~ Detroit Medical Center

Johns Hopkins orthopaedic hip and knee surgeon, Savyasachi "Savya" Thakkar, explains who is a candidate for knee replacement surgery, and what to expect during and after surgery. To learn more about our hip and knee replacement division, visit https://www.hopkinsmedicine.org/ortho #KneeReplacementSurgery #JohnsHopkins

Q&A's
0:15 What causes someone to need a knee replacement?
0:54 Describe the surgery.
1:36 What types of implants are used?
2:24 How is the recovery after surgery?
2:48 Describe the post-surgery physical therapy.
3:24 Do you perform revision surgery?

Cervical artificial disc replacement using the BRYAN Disc, a trusted product of Medtronic. Spine care offices are located in New Jersey, New York, and Florida. Are you experiencing neck pain? Do you think you may have a herniate disc? Learn more about our doctors' 97% success rate for performing BRYAN disc replacement:

Thoracentesis is used diagnostically to establish the cause of a pleural effusion. It can also be performed to drain large effusions that lead to respiratory compromise