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Normal Skin Histology - Explained by a Dermatopathologist
Normal Skin Histology - Explained by a Dermatopathologist DrPhil 135 Views • 2 years ago

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: https://kikoxp.com/posts/5084 (dermpath) & https://kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology)

Topics discussed:

Epidermis:
Layers of epidermis: 0:10
Melanocytes vs Keratinocytes: 5:16
Langerhans cells: 10:10 & 33:30 & 57:30

Dermis:
Papillary and reticular dermis: 11:50
Three types of white empty spaces on a slide: vessels, glands/ducts/cysts, or artifact: 15:25
Blood vessels & nerves: 18:24 & 48:50 & 58:59
Arrector pili & other dermal smooth muscle: 20:00

Adnexal:
Sebaceous gland: 21:10
Hair follicle 23:14
Eccrine sweat glands and ducts 24:45 & 50:00
Gland/duct vs blood vessel 27:20 & 48:50
Apocrine glands: this video https://kikoxp.com/posts/7837 (at 12:30)
Acrosyringium: this video https://kikoxp.com/posts/7837 (at 10:00)

Three types of pink bundles: smooth muscle, nerve, dense connective tissue: 27:50

Acral skin (palm sole) with contact dermatitis 29:37
Parakeratosis 30:00
Perivascular lymphocytes 30:40
Eosinophils vs neutrophils 31:20
Spongiosis with desmosome keratinocyte spines 32:10
Spongiotic vesicles with Langerhans cells 33:30
Normal acral skin (palm & sole) with stratum lucidum 34:20
Normal glomus body/apparatus (canal of Sucquet-Hoyer) 35:40
Nerve 36:46 & 51:50
Adipose tissue (white fat cells) in subcutis with Lochkern 37:55
Normal scalp skin with large anagen hair follicles: 39:30
Hair follicle anatomy (bulb/matrix, inner root sheath, outer root sheath, hair shaft, isthmus, infundibulum): 40:55 (labeled images):
https://kikoxp.com/posts/3661 & https://kikoxp.com/posts/7899
Pacinian corpuscle 50:40
Meissner corpuscle 1:02:28

Dense regular connective tissue (Fascia/Tendon/Ligament) vs Smooth Muscle 53:00

Basic Normal Skin Immunohistochemistry:
-cytokeratin in epidermis: 55:33
-S100 in melanocytes and Langerhans cells and adipocytes: 57:30
-Desmin in smooth muscle (arrector pili and blood vessels): 58:59
-CD31 in endothelial cells of blood vessels: 59:33
-SOX-10 in melanocytes: 1:00:40

Digit/Finger/Toe histology (amputation for subungual acral melanoma) 1:04:10 & 1:08:30
-bone 1:05:40
-glomus body 1:05:15
-tendon/ligament 1:06:10
-artery 1:06:58
-fingernail/toenail 1:08:54
-acrosyringium 1:10:45

Solar elastosis (what wrinkles look like microscopically!) 1:11:50

Other videos you might like:
Tendon vs Nerve Histology Made Simple with the Ramen Noodle Sign (of Fulton) video: https://kikoxp.com/posts/4466
Melanocytes vs Keratinocytes made easy video: https://kikoxp.com/posts/3802
Blood Vessel vs Gland vs Artifact Made Easy video: https://kikoxp.com/posts/4808

The basic normal structures of the skin discussed and described by a dermatopathologist. This material is intended for use by medical students, junior pathology or dermatology residents, or for anyone else studying normal human histology. Special thanks to two of my medical students at UAMS for helping make this video possible. Miki Lindsey convinced me that I really needed to sit down and record this video. Akash Patel took time to edit the video and make it ready for YouTube. My sincere thanks to both of them for helping me overcome procrastination.

Huge thanks to Abigail Cline, a medical student at Medical College of Georgia, for volunteering to type a transcript of this ENTIRE video (over 14,000 words!) so that I could provide closed caption subtitles for those with hearing impairments and for those who may need assistance in understanding spoken English (particularly given how quickly I speak!). You can access a text version of her transcript of my video here: https://kikoxp.com/posts/5390

Correction - I made a mistake in the video. I said that sebaceous gland secretions are turned into smelly substances by bacteria and that this makes body odor. That is incorrect. That is actually true of APOCRINE gland secretions not sebaceous secretions.

Also, in the past I used "keratinocyte" and "squamous cell" interchangeably (this is because in dermatopathology, we see and talk about squamous cell carcinomas all the time, and those tumors are composed of keratinocytes). But technically, in normal skin histology, "squamous cell" refers only to the flattened keratinocytes in the superficial epidermis. Thankfully, a histology PhD colleague pointed this out to me and corrected my lazy nomenclature!

Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: http://bit.ly/2Te2haB

This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.

Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.

Follow me on:
Snapchat: JMGardnerMD
Twitter: @JMGardnerMD
Instagram: @JMGardnerMD
Facebook: https://www.facebook.com/JMGardnerMD/

Human Heart Anatomy (3D Medical Animation)
Human Heart Anatomy (3D Medical Animation) Scott 173 Views • 2 years ago

Using state of the art 3D animation techniques, this video shows the anatomy of the heart. Includes close ups of the superior vena cava, rights and left atrium, the valves, the ventricles and the pulmonary artery.

Please note: this video contains no audio description or captions.

Your heart is an extraordinary machine - enjoy the visual showing you how it works :)

Copyright - Arcreative

Curious about medical device 3D animation? ➜ http://www.arcreative-media.com

Boy Returns from the Beach with a Snail Inside His Knee
Boy Returns from the Beach with a Snail Inside His Knee hooda 41,837 Views • 2 years ago

Watch that video for a Boy Returns from the Beach with a Snail Inside His Knee

Uterine Fibroid Surgery: Back to Work in 1 day
Uterine Fibroid Surgery: Back to Work in 1 day Emery King 16,797 Views • 2 years ago

DMC Surgeon uses minimally-invasive surgery to remove uterine fibroids to hasten recovery. ~ Detroit Medical Center

How The left ventricular assist device (LVAD)  Works
How The left ventricular assist device (LVAD) Works samer kareem 5,326 Views • 2 years ago

Although individual surgeons and centers employ different methods to insert a left ventricular assist device (LVAD), the fundamental concepts remain true for all. That is, most devices use the apex of the left ventricle (LV) as the inflow site to the pump, which subsequently gives off an outflow graft to the aorta, thus bypassing the ailing LV. Currently available devices do not differ significantly with regard to general implantation technique. The sequence of implantation can vary also from patient to patient, depending on the particular situation. In some cases, concomitant procedures may be performed in conjunction with LVAD implantation without adversely affecting outcome.

Coloscopy | Colon Polyp Resection | Polypectomy
Coloscopy | Colon Polyp Resection | Polypectomy Scott 106 Views • 2 years ago

https://bit.ly/3HIStRc #shorts
Coloscopy | Colon Polyp Resection | Polypectomy



Colonoscopies are essential for detecting colorectal abnormalities, including colon polyps. Polypectomy, the surgical removal of these growths, can prevent them from becoming cancerous. This article offers a brief overview of colonoscopies, colon polyps, and polypectomy procedures.

A colonoscopy is an endoscopic examination allowing healthcare providers to visualize the colon and rectum using a colonoscope. The colonoscope, a flexible tube with a camera and light source, helps detect abnormalities, including polyps or tumors.

Colon polyps are abnormal growths arising from the colon's inner lining. While most polyps are benign, some can become malignant. Adenomatous polyps have a higher potential to become cancerous, whereas hyperplastic and inflammatory polyps pose a lower risk.

Polypectomy involves removing colon polyps during a colonoscopy. Two primary techniques include snare polypectomy, using a wire loop to cut the polyp, and cold forceps polypectomy, which employs forceps to grasp and remove smaller polyps.

Following a polypectomy, patients may experience mild discomfort or bleeding. Regular surveillance is crucial to minimize colorectal cancer risk. The frequency of surveillance colonoscopies depends on the number, size, and type of polyps found, as well as the patient's overall risk factors.

Colonoscopies and polypectomies play vital roles in detecting and removing colon polyps, reducing the risk of colorectal cancer, and maintaining optimal colon health.


Do you want to learn more about colon polyps and colonoscopy? check our:

Article @ https://bit.ly/41w5Ooq



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Ectopic Pregnancy Medical Abortion Procedure
Ectopic Pregnancy Medical Abortion Procedure hooda 78,439 Views • 2 years ago

Watch that Ectopic Pregnancy Medical Abortion Procedure

EXAMINATION OF AN INCISIONAL HERNIA
EXAMINATION OF AN INCISIONAL HERNIA DrPhil 160 Views • 2 years ago

Purse String Suture
Purse String Suture Mohamed Ibrahim 20,594 Views • 2 years ago

Purse String Suture

Safety & Efficacy of A New Ointment (pedyphar)  for Diabetic Foot Ulcers
Safety & Efficacy of A New Ointment (pedyphar) for Diabetic Foot Ulcers Mostafa Yakoot 14,798 Views • 2 years ago

A Lecture Presented by Dr. Mostafa Yakoot to Vascular Surgery Congress. TITLE: SAFETY & EFFICACY OF A NEW HONEY OINTMENT (PEDYPHAR) FOR DIABETIC FOOT ULCERS. Based on the original article in JWC by: Yakoot M, Abdelatif M, Etman M.

Umbilical Cord Around Fetal Neck During Delivery
Umbilical Cord Around Fetal Neck During Delivery Medical_Videos 12,539 Views • 2 years ago

Umbilical Cord Around Fetal Neck During Delivery

How to give Enema
How to give Enema Medical_Videos 30,179 Views • 2 years ago

Enema how to apply Animation

Crown Lengthening
Crown Lengthening samer kareem 7,852 Views • 2 years ago

A palatal view of a maxillary premolar during a crown lengthening procedure. Crown lengthening is a surgical procedure performed by a dentist to expose a greater amount of tooth structure for the purpose of subsequently restoring the tooth prosthetically.

GAS pharyngitis: Diagnosis and Treatment
GAS pharyngitis: Diagnosis and Treatment samer kareem 2,779 Views • 2 years ago

The infection is generally transmitted by direct contact with the mucus or sores of someone else with strep. Common symptoms include sore throat, fever, and swollen lymph nodes in the neck. Rarely, complications can involve the heart or kidneys. Treatment is important to reduce complications. Oral antibiotics like penicillin, amoxicillin, cephalexin, or azithromycin are commonly used. Other medicines such as acetaminophen or ibuprofen can help with pain and fever.

Emphysema
Emphysema samer kareem 3,073 Views • 2 years ago

Emphysema gradually damages the air sacs (alveoli) in your lungs, making you progressively more short of breath. Emphysema is one of several diseases known collectively as chronic obstructive pulmonary disease (COPD). Smoking is the leading cause of emphysema. Your lungs' alveoli are clustered like bunches of grapes. In emphysema, the inner walls of the air sacs weaken and eventually rupture — creating one larger air space instead of many small ones. This reduces the surface area of the lungs and, in turn, the amount of oxygen that reaches your bloodstream. When you exhale, the damaged alveoli don't work properly and old air becomes trapped, leaving no room for fresh, oxygen-rich air to enter. Treatment may slow the progression of emphysema, but it can't reverse the damage.

Male Reproductive System of Human
Male Reproductive System of Human samer kareem 4,574 Views • 2 years ago

The purpose of the organs of the male reproductive system is to perform the following functions: To produce, maintain, and transport sperm (the male reproductive cells) and protective fluid (semen) To discharge sperm within the female reproductive tract during sex To produce and secrete male sex hormones responsible for maintaining the male reproductive system

Hernia in Arabic 4 ( External Abdominal Hernia , part 3 ) , by  Dr.Wahdan
Hernia in Arabic 4 ( External Abdominal Hernia , part 3 ) , by Dr.Wahdan DrPhil 165 Views • 2 years ago

Learn with Dr. Wahdan 2
You can download the lecture from this link
https://docdro.id/5ni1FFZ

Super Model's Butt and Leg Implants Exploded
Super Model's Butt and Leg Implants Exploded hooda 17,960 Views • 2 years ago

Watch that video of Super Model's Butt and Leg Implants Exploded

Tick Twister
Tick Twister Isabelle Austral 4,649 Views • 2 years ago

Tick Twister is the best way to remove ticks.

Pulmonary Artery Catheterization
Pulmonary Artery Catheterization samer kareem 1,573 Views • 2 years ago

Any independent vertical movement of the transducer or the patient will affect the hydrostatic column of this fluid-filled system and thus alter the pressure measurements. At some time before or after PAC insertion, the system must therefore be zeroed to ambient air pressure. The reference point for this is the midpoint of the left atrium (LA), estimated as the fourth intercostal space in the midaxillary line with the patient in the supine position. With the transducer at this height, the membrane is exposed to atmospheric pressure, and the monitor is then adjusted to zero. Calibration Once zeroed, the monitoring system must be calibrated for accuracy. Currently, most monitors perform an automated electronic calibration. Two methods are used to manually calibrate and check the system. If the catheter has not been inserted, the distal tip of the PAC is raised to a specified height above the LA. For example, raising the tip 20 cm above the LA should produce a reading of approximately 15 mm Hg if the system is working properly (1 mm Hg equals 1.36 cm H 2 O). Alternatively, pressure can be applied externally to the transducer and adjusted to a known level using a mercury or aneroid manometer. The monitor then is adjusted to read this pressure, and the system is calibrated. Dynamic tuning Central pressures are dynamic waveforms (ie, they vary from systole to diastole) and thus have a periodic frequency. To monitor these pressures accurately, the system requires an appropriate frequency response. A poorly responsive system produces inaccurate pressure readings, and differentiating waveforms (eg, PA from pulmonary capillary wedge pressure [PCWP]) can become difficult. When signal energy is lost, the pressure waveform is dampened. Common causes of this are air bubbles (which are compressible), long or compliant tubing, vessel wall impingement, intracatheter debris, transducer malfunction, and loose connections in the tubing. A qualitative test of the frequency response is performed by flicking the catheter and observing a brisk high-frequency response in the waveform. After insertion, the system can be checked by using the rapid flush test. When flushed, an appropriately responsive system shows an initial horizontal straight line with a high-pressure reading. Once the flushing is terminated, the pressure drops immediately, which is represented by a vertical line that plunges below the baseline. A brief and well-defined oscillation occurs, followed by return of the PA waveform. A dampened system will not overshoot or oscillate, and causes a delay in returning to the PA waveform.

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