Lecture delivered by Dr. Mostafa Yakoot, MD, to the 12th Allergy Conference

The vast majority of glucocorticoid activity in most mammals is from cortisol, also known as hydrocortisone. Corticosterone, the major glucocorticoid in rodents, is another glucocorticoid. Cortisol binds to the glucocorticoid receptor in the cytoplasm and the hormone-receptor complex is then translocated into the nucleus, where it binds to its DNA response element and modulates transcription from a battery of genes, leading to changes in the cell's phenotype. Only about 10% of circulating cortisol is free. The remaining majority circulates bound to plasma proteins, particularly corticosteroid-binding globulin (transcortin). This protein binding likely decreases the metabolic clearance rate of glucocorticoids and, because the bound steroid is not biologically active, tends to act as a buffer and blunt wild fluctuations in cortisol concentration.

Hypothyroidism during pregnancy is treated with synthetic thyroid hormone, thyroxine (T4). Postpartum thyroiditis—inflammation of the thyroid gland—causes a brief period of hyperthyroidism, often followed by hypothyroidism that usually goes away within a year. Sometimes the hypothyroidism is permanent.

The usual reason given for people getting fat is that they eat too much and/or exercise too little. That reflects one of the basic laws of thermodynamics—I forget which one. The amount of energy you put into a system minus the energy you take out has to be stored somewhere i.e. FAT! This formulation—true though it is—does not entirely explain obesity since some people seem to eat more than fat people and exercise no more than these same fat people, and yet they are not fat! Chalking this fact up to the general perversity of the universe is not sufficient explanation. Other factors must come into play. I mention below some of the ideas thoughtful people have proposed to explain why fat people become fat:

Using state of the art 3D animation techniques, this video shows the anatomy of the heart. Includes close ups of the superior vena cava, rights and left atrium, the valves, the ventricles and the pulmonary artery.

Please note: this video contains no audio description or captions.

Your heart is an extraordinary machine - enjoy the visual showing you how it works :)

Copyright - Arcreative

Curious about medical device 3D animation? ➜ http://www.arcreative-media.com

An excellent video demonstrating how a laparoscopy is performed to evaluate the uterus (note a small fibroid appearing as a bulge in the uterus), fallopian tubes and ovaries. Blue dye is injected into the uterus, entering the fallopian tubes and spilling from the end of the tubes into the abdominal cavity, confirming that both tubes are open

An excerpt from the award-winning documentary “Exposure: Environmental Links to Breast Cancer” about the effects of radiation. Featuring Olivia Newton-John, Dr. Rosalie Bertell and Dr. Susan Love.

High Resolution Upper Airway Anatomy

Wilms tumor, also known as nephroblastoma, is a cancer of the kidneys that typically occurs in children, rarely in adults. It is named after Dr. Max Wilms, the German surgeon (1867–1918) who first described it. Approximately 500 cases are diagnosed in the U.S. annually.

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Survivor is coming up on its 43rd season this fall (whaaat??), and with all that reality TV goodness in the can already I knew there would be some medical moments to react to. Turns out, I was right, in that there have been a bunch of ailments on the show over the years! These injuries span the entire length of the whole series, so if you're a long time Survivor and Jeff Probst fan, this one is for you!

I LOVE reading your comments and take your suggestions seriously. If there’s a subject you want me to discuss or something you’d like for me to react to, leave a comment down below. Many of my videos have been born out of suggestions directly from you, so don’t hold back!
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Executive Producer: Doctor Mike
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* Select photos/videos provided by Getty Images *

** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional **

Watch that Human Brain Removal During Medical Autopsy

Acute bronchitis and pneumonia share many of the same symptoms, and some people with acute bronchitis are at risk for getting pneumonia. Although acute bronchitis usually goes away within a few weeks, pneumonia can be a serious condition, especially in older adults. The following table outlines some differences between acute bronchitis and pneumonia. There are variations in symptoms of both conditions, so if you think you might have pneumonia, always check with your doctor.

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This is one of the most interesting medical topics to discuss. What are the responsibilities of a doctor? What are the basic skills a doctor needs to have? and what are the responsibilities of a doctor?

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This video will cover, in detail, the motor, sensory, reflect components of a neurological examination.

This video is created for the UBC Medicine Neurology Clinical Skills curriculum as part of MEDD 419 FLEX projects.

Filmed, written, and directed by:
John Liu
Vincent Soh
Chris Calvin
Kashi (Siyoung) Lee
Kero (Yue) Yuen
Ge Shi

Doctor - Dr. Jason Valerio (Department of Neurology, UBC)

Supervised by:
Dr. Alex Henri-Bhargava (Department of Neurology, UBC)
Zac Rothman (UBC FOM Digital Solutions: Ed Tech)

Edited by:
Stephen Gillis

Produced by UBC FOM Digital Solutions EdTech team facilitates innovation by UBC Medicine learners and faculty.

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All you need to know about the female orgasm

Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye. It may result in permanent visual impairment or blindness.

poor posture (postural kyphosis) – slouching, leaning back in chairs and carrying heavy bags can stretch supporting muscles and ligaments, which can increase spinal curvature. abnormally shaped vertebrae (Scheuermann's kyphosis) – if the vertebrae don't develop properly, they can end up being out of position.

Lower Limb Physical Examination

An animation showing the Pelvic Inflammatory Disease (PID)