Massive PE causing hemodynamic instability (shock and/or low blood pressure, defined as a systolic blood pressure <90 mmHg or a pressure drop of 40 mmHg for >15 min if not caused by new-onset arrhythmia, hypovolemia or sepsis) is an indication for thrombolysis, the enzymatic destruction of the clot with medication.

Possible causes include a combination of biological, psychological, and social sources of distress. Increasingly, research suggests these factors may cause changes in brain function, including altered activity of certain neural circuits in the brain. The persistent feeling of sadness or loss of interest that characterizes major depression can lead to a range of behavioral and physical symptoms. These may include changes in sleep, appetite, energy level, concentration, daily behavior, or self-esteem. Depression can also be associated with thoughts of suicide. The mainstay of treatment is usually medication, talk therapy, or a combination of the two. Increasingly, research suggests these treatments may normalize brain changes associated with depression.

The vast majority of glucocorticoid activity in most mammals is from cortisol, also known as hydrocortisone. Corticosterone, the major glucocorticoid in rodents, is another glucocorticoid. Cortisol binds to the glucocorticoid receptor in the cytoplasm and the hormone-receptor complex is then translocated into the nucleus, where it binds to its DNA response element and modulates transcription from a battery of genes, leading to changes in the cell's phenotype. Only about 10% of circulating cortisol is free. The remaining majority circulates bound to plasma proteins, particularly corticosteroid-binding globulin (transcortin). This protein binding likely decreases the metabolic clearance rate of glucocorticoids and, because the bound steroid is not biologically active, tends to act as a buffer and blunt wild fluctuations in cortisol concentration.

Depression is a very serious mental illness that affects millions worldwide. Could a small brain implant cure it?

The spleen plays multiple supporting roles in the body. It acts as a filter for blood as part of the immune system. Old red blood cells are recycled in the spleen, and platelets and white blood cells are stored there. The spleen also helps fight certain kinds of bacteria that cause pneumonia and meningitis

Septoplasty (SEP-toe-plas-tee) is a surgical procedure to correct a deviated septum — a displacement of the bone and cartilage that divides your two nostrils. During septoplasty, your nasal septum is straightened and repositioned in the middle of your nose.

Breast implants do not last forever, and during its lifetime, it may rupture. Dr. Linder, Beverly Hills breast surgeon specialist, breaks down how removing breast implants works. To learn more about Dr. Stuart Linder and his expertise, Visit: www.drlinder.com

A video discussing the importance of following up the blood pressure for diabetic patients and the serious complications that they can avoid by this very simple measure.

Osteoporosis

Cervical Mucus

The usual reason given for people getting fat is that they eat too much and/or exercise too little. That reflects one of the basic laws of thermodynamics—I forget which one. The amount of energy you put into a system minus the energy you take out has to be stored somewhere i.e. FAT! This formulation—true though it is—does not entirely explain obesity since some people seem to eat more than fat people and exercise no more than these same fat people, and yet they are not fat! Chalking this fact up to the general perversity of the universe is not sufficient explanation. Other factors must come into play. I mention below some of the ideas thoughtful people have proposed to explain why fat people become fat:

During your menstrual period, your uterus contracts to help expel its lining. Hormonelike substances (prostaglandins) involved in pain and inflammation trigger the uterine muscle contractions. Higher levels of prostaglandins are associated with more-severe menstrual cramps.

What Really Happens When You Swallow Gum?

Gynecomastia 3D Animation

Vaginoplasty is any surgical procedure that results in the construction or reconstruction of the vagina. It is a type of genitoplasty. Pelvic organ prolapse is often treated with one or more surgeries to repair the vagina.

Rapid cycling is a pattern of frequent, distinct episodes in bipolar disorder. In rapid cycling, a person with the disorder experiences four or more episodes of mania or depression in one year

Few facts and information are summed up in this short video related to Mental Health, Psychiatry and Depression.