Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target guanines. Cisplatin can bond more tightly with nitrogen because nitrogen balances the platinum charge more effectively than chlorine. It is this adduct-induced DNA bend that allows binding of proteins which contain the high mobility group, HMG domain. Once the protein is bound to the DNA, it inserts a wedge-like phenyl group of phenylalanine 37 into the widened minor groove created by the bend. The tightly bound HMG protein causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, Cisplatin can be thought of as a monkey wrench in the DNA repair system. With the HMG protein bound to the DNA, the modified strand is not repaired properly and so the cell dies. The success of Cisplatin depends on its ratio of efficacy between cancerous and healthy cells.

Harper University Hospital has been accredited as a Bariatric Center of Excellence by the American Society of Bariatric Surgeons. By employing laparoscopy, this bariatric procedure is minimally invasive and results in quicker recovery time, as well as less scarring. ~ Detroit Medical Center

Pomeroy Tubal Ligation during a C-Sections

emergency c-section for acute fetal distress, Misgav Ladach - modified Joel Cohen technique

Austin arm lift surgery (also commonly referred to as Brachioplasty) reduces excess skin and tissue from the under arm region, leaving the patient with smoother, more contoured arms. Visit http://www.austinplasticsurgery.com/body-contouring.php for more info.

Clogged leg arteries can be opened through a minimally invasive procedure with the SILVERHAWK, a mini drill with a tiny rotating blade for cutting away plaque. The procedure only involves a tiny puncture in the patient's groin. ~ Detroit Medical Center

DMC pain management Specialists Drs. Renee Baugh and Mohamed Othman work to help patients manage and minimize pain, and restore a more satisfying lifestyle. ~ Detroit Medical Center

Here we’ll explain the symptoms of pancreatitis, how alcohol causes the condition and the other health problems it can lead to. You probably don’t pay much attention to your pancreas. But that small, tadpole-shaped organ behind your stomach and below your ribcage is pretty important. It produces two essential substances: digestive juices which your intestines use to break down food, and hormones that are involved in digestion, such as insulin, which regulates your blood sugar levels. Pancreatitis is when your pancreas becomes inflamed and its cells are damaged. Heavy drinking can cause pancreatitis. But if you drink within the government’s low risk unit guidelines, you should avoid upsetting this important organ.

Vital signs help us assess patients in the nursing profession, and there are six common vital signs that we assess as nurses:

1. Heart Rate (Pulse)
2. Respiration Rate
3. Temperature
4. Blood Pressure
5. Pain Rating
6. Oxygen Saturation

This video will demonstrate how to check vital signs (live) on a patient, along with normal rates for each assessment. I also give you a few tips for taking vital signs as a nurse, CNA, or other healthcare profession.

🟣ABG eBook: https://registerednursern.creator-spring.com/
🟣ABG physical book: https://amzn.to/3EsF0Mc (affiliate link)

More nursing skills: https://www.youtube.com/watch?v=G5-Rp-6FMCQ&list=PLQrdx7rRsKfUhd_qQYEbp0Eab3uUKhgKb

Website: https://www.registerednursern.com/
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Nursing Gear: https://teespring.com/stores/registerednursern
Instagram: https://www.instagram.com/registerednursern_com/
Facebook: https://www.facebook.com/RegisteredNurseRNs
Twitter: https://twitter.com/NursesRN


Popular Playlists:

NCLEX Reviews: https://www.youtube.com/playli....st?list=PLQrdx7rRsKf
Fluid & Electrolytes: https://www.youtube.com/playli....st?list=PLQrdx7rRsKf
Nursing Skills: https://www.youtube.com/playli....st?list=PLQrdx7rRsKf

A new and safer method of inserting a Foley catheter suprapubically. The technique allows the insertion to be carried out in an Outpatient setting, thus saving time, cost and effort. By using the Seldinger technique, the product reduces the chances of bowel or bladder perforation and resultant morbidity.
The product has been chosen by The NHS National Technology Adoption Centre to help facilitate adoption of the product.
See www.mediplus.co.uk for more information

Female Intermittent Self Catheterization

There are several things to consider when trying to decide between gastric bypass surgery and gastric sleeve surgery. Unlike the laparoscopic adjustable gastric band (Lap Band), these two operations are both permanent, reduce hunger, and lead to the highest percentage of weight loss. To properly compare gastric sleeve surgery to gastric bypass surgery we will examine the following data : Expected weight loss. Speed of weight loss. Time of surgery. Gastric bypass benefits over sleeve. Gastric sleeve benefits over bypass. Risk of complications. Surgeon skill and preference.

Website : https://www.udemy.com/course/h....istology/?referralCo

Human Histology is one of the basic subject in a Medical Student career. By learning Histology in a proper way, this will help you to get a Visual memory of the Human body. Using this Visual memory, you can Learn any other subjects with little effort. 

This Course is very well organized with lot of Histology images, Line diagrams, simple presentations and clear Explanations. This course has 33 videos, 19 chapters, 6 hours long covering all topics. Every topic is made Simple and Complete. Dr Ram has a great teaching style and has a good experience in teaching medical subjects to students.

After finishing this course, you will be better in your basics, with ability to visualize the human body and this will create an intense thirst to learn more. We give 100% guarantee that you will have a complete and in-depth understanding in short time, You will start to enjoy Learning Medicine because of the visualization of human body you get from this course and you will be ready to face any Medical exams in world. 

Course features:

- Complete Histology lectures covering all chapters

- 19 chapters | 33 Videos | 6 Hours

- Clear Histology images

- Line diagrams for easy understanding

- Lot of memory tips

- High quality audio and Videos

- Can be viewed in Pc, or Phones or TV

Course content: ( 19 Chapters, 33 videos )

I The Cell - 3 Lessons

1. Nucleus

2. Cytoplasm

3. Cell Junctions

II Tissues - 11 Lessons

4. Epithelial tissues

5. Connective tissues

6. Muscular tissues

7. Nervous tissues

8. Bones

9. Cartilage

10. Lymphoid tissues

III Organ systems - 19 Lessons

11. Cardiovascular system

12. Respiratory system

13. Gastrointestinal system

14. Liver and Exocrine pancreas

15. Endocrine system

16. Urinary system

17. male reproductive system

18. Female reproductive system

19. The skin

Instructor : Dr Ram , Med Madness

This video will describe how to check the positions of different tubes that may be inserted and need to be checked on CXRs.

Elbow Exam - Orthopaedic OSCE - Clinical Skills - Dr Gill

The elbow examination is a core skill - in this video, we demonstrate how to perform an elbow EXAM for an Orthopaedic Clinical Skills OSCE, which should be one of the more accessible examination stations for medical students.

For a passing grade in your Clinical Skills OSCE, an elbow assessment should follow the LOOK, FEEL, MOVE approach

Initially looking for erythema, scars, swelling and position

Palpating the elbow - specifically the olecranon, medial and lateral epicondyles, and radial head for heat, oedema and crepitus

Finally assess range of movement with flexion and extension at the elbow, before determining for tennis and golfers' elbows

Watch further orthopaedic examinations for your OSCE revision:

The Elbow - Deep Dive
https://youtu.be/SX5buhtCVDw

The Spine Examination:
https://youtu.be/pJxMHa6SCgU

The Knee examination
https://youtu.be/oyKH4EYfJDM

The Hip examination
https://youtu.be/JC9GKq5nSdQ

The GALS examination
https://youtu.be/5qJaf7gW-B0 - Gait, Arms, Legs, Spine - GALS screen

------------

Please note that there is no ABSOLUTE way to perform a clinical examination. Different institutions and even clinicians will have differing degrees of variations - the aim is the effectively identify medically relevant signs.

However during OSCE assessments. Different medical schools, nursing colleges and other health professional courses will have their own preferred approach to a clinical assessment - you should concentrate on THEIR marks schemes for your assessments.

The examination demonstrated here is derived from Macleods Clinical Examination - a recognised standard textbook for clinical skills.

Some people viewing this medical examination video may experience an ASMR effect

#clinicalskills #Elbow #DrGill

Debridement of an Infected Diabetic Wound on the patients foot. The first is a series of online diabetic foot care videos by The Mayer Institute. Themayerinstitute.ca

"Laparoscopic Placement of a
Peritoneal Dialysis Catheter"

Houston Methodist DeBakey Heart & Vascular Center, presents a cardiovascular procedure featuring Eric K. Peden, MD, Shri Timbalia, MD, and Kenneth Livingston as they demonstrate “Laparoscopic Placement of a
Peritoneal Dialysis Catheter".

Surgery: Eric K. Peden, MD, Shri Timbalia, MD, and Kenneth Livingston
Narration: Kenneth Livingston

** This medical education program may contain graphic content. **
_________________________________

A DeBakey CV Education event

Presented by Houston Methodist DeBakey Heart & Vascular Center.

Building on Dr. Michael E. DeBakey’s commitment to excellence in education, Houston Methodist DeBakey CV Education is an epicenter for cardiovascular academic and clinical educational programs that support the provision of optimal care to patients suffering from cardiovascular conditions and diseases.

FOR MORE INFORMATION
DeBakey CV Education:
https://www.houstonmethodist.o....rg/education/medical

For the latest education and training opportunities from DeBakey CV Education: http://bit.ly/HMdebakeyemail

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Want concise, relevant reviews of the hottest topics in CV medicine? Subscribe for FREE to the Methodist DeBakey Cardiovascular Journal for quarterly, peer-reviewed issues delivered to your door.
https://journal.houstonmethodist.org/

Prenatal repair of myelomeningocele (MMC), the most common and severe form of spina bifida, is a delicate surgical procedure where fetal surgeons open the uterus and close the opening in the baby's back while they are still in the womb.

Every 10 minutes, someone is added to the national transplant waiting list, and every day, 22 people on average die waiting for a match, according to the United Network for Organ Sharing. But, thanks to innovations in bioengineering, all of that could change. Conceived nearly 60 years ago, the total artificial heart (TAH) has helped sustain the sickest biventricular failure patients waiting for a transplant. While the design of the primary TAH used today has mostly remained stagnant since the ’80s, when it was first implanted in a patient, new models and clinical trials may lead to a better device and, one day, a permanent solution. “We are still many years away from that,” Dr. Nader Moazami, director of the Cardiac Transplantation and Ventricular Assist Device Therapy Program at the Cleveland Clinic, told FoxNews.com of a permanent artificial heart. “Although tremendous strides have been made, biocompatibility will always remain a challenge.”