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The vast majority of glucocorticoid activity in most mammals is from cortisol, also known as hydrocortisone. Corticosterone, the major glucocorticoid in rodents, is another glucocorticoid. Cortisol binds to the glucocorticoid receptor in the cytoplasm and the hormone-receptor complex is then translocated into the nucleus, where it binds to its DNA response element and modulates transcription from a battery of genes, leading to changes in the cell's phenotype. Only about 10% of circulating cortisol is free. The remaining majority circulates bound to plasma proteins, particularly corticosteroid-binding globulin (transcortin). This protein binding likely decreases the metabolic clearance rate of glucocorticoids and, because the bound steroid is not biologically active, tends to act as a buffer and blunt wild fluctuations in cortisol concentration.
Guest surgeon Dr. Nicole Callan gives us an introduction to hernias. She discusses what a hernia is, the different types of hernias, and an introduction to treatment.
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This video demonstrates how to perform a cardiovascular examination in an OSCE station.
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Chapters:
- Introduction 00:00
- General inspection 00:35
- Hands 00:46
- Schamroth's window test 01:07
- Capillary refill 01:27
- Pulses 01:35
- Carotid auscultation 02:21
- Carotid pulse 02:43
- Jugular venous pressure 02:55
- Hepatojugular reflux 03:09
- Inspection of the face 03:21
- Inspection of the chest 03:49
- Apex beat 04:12
- Heaves and thrills 04:28
- Heart valve ausculation 04:49
- Accentuation manoeuvres 05:45
- Lung base auscultation 06:23
- Sacral and pedal oedema 06:43
- Summary 07:10
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Normal heart sounds and aortic regurgitation/stenosis sounds
Recorded on a Thinklabs Digital Stethoscope (https://www.thinklabs.com)
Some people have found this video useful for ASMR purposes.
Pleurisy is a condition in which the pleura — a membrane consisting of a layer of tissue that lines the inner side of the chest cavity and a layer of tissue that surrounds the lungs — becomes inflamed. Also called pleuritis, pleurisy causes sharp chest pain (pleuritic pain) that worsens during breathing. A variety of underlying conditions can cause pleurisy. Treatment of pleurisy involves pain control and treating the underlying condition.
They might not sound very life threatening, but a blood clot that develops in the deep veins of your leg, if left untreated and unable to dissolve of its own volition, may detach and travel to your lungs, causing a pulmonary embolism (or PE). In most cases, a leg blood clot will form due to lengthy periods of travel, for example if you remain immobile in cramped spaces—such as an airplane or bus—with few opportunities to stretch your legs or get up and walk around. Here are ten signs that you may have a dangerous blood clot in your leg
Among common cancers, pancreatic cancer has one of the poorest prognoses. Because pancreatic cancer often grows and spreads long before it causes any symptoms, only about 6% of patients are still alive five years after diagnosis. For some pancreatic patients, however, a complex surgery known as the Whipple procedure may extend life and could be a potential cure. Those who undergo a successful Whipple procedure may have a five-year survival rate of up to 25%.