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28 years old gentleman presented with huge liver abscess in the right lobe, with repeated attempts of percutaneous aspirations in the past. He was evaluated and subjected to Laparoscopic drainage. This video depicts feasibility of laparoscopy in deep seated liver abscesses. Video created by: Dr. Juneed M. Lanker Fellow Minimal Access Surgery Apollo Hospitals Chennai.
Current treatment is a combination of pegylated interferon-alpha-2a or pegylated interferon-alpha-2b (brand names Pegasys or PEG-Intron) and the antiviral drug ribavirin for a period of 24 or 48 weeks, depending on hepatitis C virus genotype. In a large multicenter randomized control study among genotype 2 or 3 infected patients (NORDymanIC),[35] patients achieving HCV RNA below 1000 IU/mL by day 7 who were treated for 12 weeks demonstrated similar cure rates as those treated for 24 weeks.[36][37]
Pegylated interferon-alpha-2a plus ribavirin may increase sustained virological response among patients with chronic hepatitis C as compared to pegylated interferon-alpha-2b plus ribavirin according to a systematic review of randomized controlled trials .[38] The relative benefit increase was 14.6%. For patients at similar risk to those in this study (41.0% had sustained virological response when not treated with pegylated interferon alpha 2a plus ribavirin), this leads to an absolute benefit increase of 6%. About 16.7 patients must be treated for one to benefit (number needed to treat = 16.7; click here [39] to adjust these results for patients at higher or lower risk of sustained virological response). However, this study's results may be biased due to uncertain temporality of association, selective dose response.
Treatment is generally recommended for patients with proven hepatitis C virus infection and persistently abnormal liver function tests.
Treatment during the acute infection phase has much higher success rates (greater than 90%) with a shorter duration of treatment; however, this must be balanced against the 15-40% chance of spontaneous clearance without treatment (see Acute Hepatitis C section above).
Those with low initial viral loads respond much better to treatment than those with higher viral loads (greater than 400,000 IU/mL). Current combination therapy is usually supervised by physicians in the fields of gastroenterology, hepatology or infectious disease.
The treatment may be physically demanding, particularly for those with a prior history of drug or alcohol abuse. It can qualify for temporary disability in some cases. A substantial proportion of patients will experience a panoply of side effects ranging from a 'flu-like' syndrome (the most common, experienced for a few days after the weekly injection of interferon) to severe adverse events including anemia, cardiovascular events and psychiatric problems such as suicide or suicidal ideation. The latter are exacerbated by the general physiological stress experienced by the patient.
A lot of women want to know what type of vaginal discharge is normal during pregnancy, and when you're not pregnant. So let's start out by talking about what's normal when you're not pregnant. It's normal to have about 1/2 teaspoon to 1 teaspoon of whitish, creamy, tannish discharge on most days of your cycle in between periods, with the exception of the time of ovulation. Actually, around the time of ovulation, it's normal to notice the discharge becoming more slippery and clear, almost like egg whites. And this is actually a sign that you can watch for to know when you're ovulating. And if you're seeing this type of discharge and you're trying to have a baby, then you should start to time intercourse with ovulation to increase your chances of conceiving.
Ingrown toenails occur in both men and women. According to the National Health Services (NHS), ingrown toenails may be more common in people with sweaty feet, such as teenagers. Older people may also be at higher risk because toenails thicken with age. Many things can cause an ingrown toenail, including: cutting toenails incorrectly (Cut straight across, since angling the sides of the nail can encourage the nail to grow into the skin.) irregular, curved toenails footwear that places a lot of pressure on the big toes, such as socks and stockings that are too tight or shoes that are too tight, narrow, or flat for your feet toenail injury, including stubbing your toe, dropping something heavy on your foot, or kicking a ball repeatedly poor posture improper foot hygiene, such as not keeping your feet clean or dry genetic predisposition
Alagille syndrome (AS) is an autosomal dominant disorder (OMIM 118450) associated with abnormalities of the liver, heart, skeleton, eye, and kidneys and a characteristic facial appearance. In 1973, Watson and Miller reported 9 cases of neonatal liver disease with familial pulmonary valvular stenosis.
“Endo” is the Greek word for “inside” and “odont” is Greek for “tooth.” Endodontic treatment treats the inside of the tooth. Root canal treatment is one type of endodontic treatment. To understand endodontic treatment, it helps to know something about the anatomy of the tooth. Inside the tooth, under the white enamel and a hard layer called the dentin, is a soft tissue called the pulp. The pulp contains blood vessels, nerves, and connective tissue and creates the surrounding hard tissues of the tooth during development.
Ever considered getting laser eye surgery, but didn’t know how it worked? Allow us to help!
There are three different main types of laser eye surgery: LASIK, SMILE, and Surface Laser Treatments, and each can be explained pretty easily.
LASIK uses two lasers to open up a thin flap on the surface of the cornea, and then reshapes the cornea underneath. The flap is then placed back over the reshaped cornea, and heals independently with time.
SMILE uses one laser to reshape the cornea through a small, self-healing hole.
And Surface Eye Treatments remove the clear skin over the eye, to then reshape the cornea underneath with - you guessed it - a laser!