Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication. The mechanism involved in its activity against rheumatoid arthritis is not known.

Barrett's esophagus is a complication of chronic (long lasting) and usually severe gastrointestinal reflux disease (GERD), but occurs in only a small percentage of patients with GERD. Criteria are needed for screening patients with GERD for Barrett's esophagus. Until validated criteria are available, it seems reasonable to do screening endoscopies in GERD patients who cannot be taken off acid suppression therapy after two to three years. The diagnosis of Barrett's esophagus rests upon seeing (at endoscopy) a pink esophageal lining that extends a short distance (usually less than 2.5 inches) up the esophagus from the gastroesophageal junction and finding intestinal type cells (goblet cells) on biopsy of the lining. There is a small but definite increased risk of cancer of the esophagus (adenocarcinoma) in patients with Barrett's esophagus.

Lewy body dementia, also known as dementia with Lewy bodies, is the second most common type of progressive dementia after Alzheimer's disease dementia. Protein deposits, called Lewy bodies, develop in nerve cells in the brain regions involved in thinking, memory and movement (motor control). Lewy body dementia causes a progressive decline in mental abilities. People with Lewy body dementia may experience visual hallucinations, and changes in alertness and attention. Other effects include Parkinson's disease-like symptoms such as rigid muscles, slow movement and tremors.

Tension pneumothorax develops when a lung or chest wall injury is such that it allows air into the pleural space but not out of it (a one-way valve). As a result, air accumulates and compresses the lung, eventually shifting the mediastinum, compressing the contralateral lung, and increasing intrathoracic pressure enough to decrease venous return to the heart, causing shock. These effects can develop rapidly, particularly in patients undergoing positive pressure ventilation.

Following Dr. Eric Skarsgard on his grueling 19-hour day at BC Children's Hospital, we meet several of his patients -- some of who need surgery that day, and some who have chronic conditions and need regular check-ups with him -- and learn how he works with medical students and on research projects as time allows.

Not sure what to expect with your child's upcoming surgery at Wesley Children's Hospital? This guided tour will walk you through the process to make both patients and families feel as comfortable as possible.

The National Institute of Allergy and Infectious Diseases explains food allergy and offers tips on how to manage the condition.

pediatric tracheostomy

Otto Placik MD. a board certified Chicago Illinois based plastic surgeon presents instructional video on post genital surgery (labia minora reduction aka labiaplasty or labioplasty or clitoral hood reduction) massage exercises for treatment of labum minora psot surgical fibrosis or hypersensitivity. Photos pictures and video of anatomic models are reviewed . Great for patients thinking about or planning labiaplasty or vaginal cosmetic surgery

Clinical Anatomy Lecture Illustrate The Anatomy Of The Abdominal Wall

Osteoporosis is a disease in which bones become brittle and fragile due to low bone mass and bone tissue loss. It's the most common type of bone disease, according to the National Institutes of Health (NIH), and increases your risk of fractures, particularly of the hips, spine, and wrists. Prevalence In the United States, nearly 54 million people ages 50 and older were living with osteoporosis or osteopenia (low bone mass ) in 2010, according to a 2014 article in the Journal of Bone and Mineral Research. More specifically, 10.2 million adults had osteoporosis, and 43.4 million adults had osteopenia, which puts a person at high risk for osteoporosis.

This one goes out to all the student, resident and fellows trying to clarify what their bosses are trying to say to the patient

Electrical cardioversion is a procedure in which an electric current is used to reset the heart's rhythm back to its regular pattern (normal sinus rhythm). The low-voltage electric current enters the body through metal paddles or patches applied to the chest wall.

An animation of blood flow inside the hollow fiber of a hemofilter, or a dialyzer, and the flow of the dialysate in an opposite direction with increased extraction of waste and small molecules from the blood as the concentration of these molecules is reduced downstream and exposed to new dialysate.

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An animation illustrating valvular heart surgery

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posterior augmentation

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Formerly called toxemia, preeclampsia is a condition that pregnant women develop. It is marked by high blood pressure in women who have previously not experienced high blood pressure before. Preeclamptic women will have a high level of protein in their urine and often also have swelling in the feet, legs, and hands.

Basic Abdominal Clinical Exam