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Minimally invasive open thyroidectomy (MIT) is similar to conventional thyroidectomy in its surgical approach. The major difference is the length of the neck incision. A smaller incision improves cosmesis and reduces discomfort. Typically, a skin incision less than 6 cm is considered minimally invasive. The remainder of the procedure is exactly the same as is used in conventional thyroidectomy. Adaptations to this technique include transection rather than lateral retraction of the strap muscles (the Sofferman technique). [1]

Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target guanines. Cisplatin can bond more tightly with nitrogen because nitrogen balances the platinum charge more effectively than chlorine. It is this adduct-induced DNA bend that allows binding of proteins which contain the high mobility group, HMG domain. Once the protein is bound to the DNA, it inserts a wedge-like phenyl group of phenylalanine 37 into the widened minor groove created by the bend. The tightly bound HMG protein causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, Cisplatin can be thought of as a monkey wrench in the DNA repair system. With the HMG protein bound to the DNA, the modified strand is not repaired properly and so the cell dies. The success of Cisplatin depends on its ratio of efficacy between cancerous and healthy cells.

A high definition HD video of Laparoscopic Cholecystectomy surgery

Skin cancer is the most common of all cancer types, accounting for an estimated one third of all new cases. It’s important to take the right steps to ensure proper protection and adopt good sun care habits no matter what your age or stage in life.

Bugs Removal from Ear Canal

An automated external defibrillator or AED is a portable electronic device that automatically diagnoses the potentially life threatening cardiac arrhythmias of ventricular fibrillation and ventricular tachycardia in a patient,[1] and is able to treat them through defibrillation, the application of electrical therapy which stops the arrhythmia, allowing the heart to reestablish an effective rhythm. The first AED was originally designed and created by American biomedical engineer Joshua L. Koelker and Italian emergency medical professional Jordan M. Blondino to allow defibrillation in common public places. AEDs are designed to be simple to use for the layman, and the use of AEDs is taught in many first aid, first responder, and basic life support (BLS) level CPR classes.

Parasites Accidentally Seen During Colonoscopy

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Giant cell tumour is a locally aggressive primary bone tumour, located eccentrically in the metaphysis and epiphysis of a long bone. It commonly affects distal end of Femur, proximal end of Tibia and distal end of Radius. It is occasionally reported in small bones of hand and foot[1], spine[2] and pelvis[3]. Though it occurs in 20 - 35 year old individuals commonly, it can also be seen in children as young as 2 years[4] and also in older individuals

Carpal Tunnel Syndrome Information

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Kidney is most essential organ to remove nitrogenous waste materials from the body. Kidney was damaged by several human activities leads to kidney failure. Once it is damaged it cannot perform basic functions. To overcome this problem one of the best method we follows called hemodialysis. Hemodialysis is a process of removing of nitrogenous waste materials and excess fluids from the blood (collecting from arteries) through tubes containing semi permeable linings in the dialyzer and sending purified blood to the patient's body through veins. It covers the process of hemodialysis in step wise manner. Hemodialysis only performs some basic functions not all those which are performed by natural kidney like reabsorption etc..

HIV stands for human immunodeficiency virus. If left untreated, HIV can lead to the disease AIDS (acquired immunodeficiency syndrome). Unlike some other viruses, the human body can’t get rid of HIV completely. So once you have HIV, you have it for life. HIV attacks the body’s immune system, specifically the CD4 cells (T cells), which help the immune system fight off infections. If left untreated, HIV reduces the number of CD4 cells (T cells) in the body, making the person more likely to get infections or infection-related cancers. Over time, HIV can destroy so many of these cells that the body can’t fight off infections and disease. These opportunistic infections or cancers take advantage of a very weak immune system and signal that the person has AIDS, the last state of HIV infection. No effective cure for HIV currently exists, but with proper treatment and medical care, HIV can be controlled. The medicine used to treat HIV is called antiretroviral therapy or ART. If taken the right way, every day, this medicine can dramatically prolong the lives of many people with HIV, keep them healthy, and greatly lower their chance of transmitting the virus to others. Today, a person who is diagnosed with HIV, treated before the disease is far advanced, and stays on treatment can live a nearly as long as someone who does not have HIV.

Most people with TS are not significantly impaired by their symptoms and therefore do not require treatment with medication. However, several medications are available to control TS symptoms that interfere with functioning. Except in more severe cases when tics are sometimes painful, the main reasons for medication are to improve appearance and lessen embarrassing social interactions. As with all medications, there are possible side effects that should be monitored carefully by the physician. Patients should always be included in the decision to take medication, as they are the best judge of how disruptive the symptoms are to them. Early diagnosis and treatment are crucial to help the person with TS cope with his or her condition. Often, people make fun of a person with TS. Parents of children with TS also may find it difficult to cope with their child's behavior. When people with TS are diagnosed correctly and treated for the condition early, they can learn to cope with their disorder and accept that they are ok and normal.