Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication. The mechanism involved in its activity against rheumatoid arthritis is not known.

Skin grafting is a type of medical grafting involving the transplantation of skin. The transplanted tissue is called a skin graft. Skin grafting is often used to treat: Extensive wounding or trauma Burns Areas of extensive skin loss due to infection such as necrotizing fasciitis or purpura fulminans Specific surgeries that may require skin grafts for healing to occur – most commonly removal of skin cancers. Skin grafts are often employed after serious injuries when some of the body’s skin is damaged. Surgical removal (excision or debridement) of the damaged skin is followed by skin grafting. The grafting serves two purposes: it can reduce the course of treatment needed (and time in the hospital), and it can improve the function and appearance of the area of the body which receives the skin graft. There are two types of skin grafts, the more common type is where a thin layer is removed from a healthy part of the body (the donor section), like peeling a potato, or a full thickness skin graft, which involves pitching and cutting skin away from the donor section. A full thickness skin graft is more risky, in terms of the body accepting the skin, yet it leaves only a scar line on the donor section, similar to a Cesarean section scar. For full thickness skin grafts, the donor section will often heal much more quickly than the injury and is less painful than a partial thickness skin graft.

I talk about 5 Essential Skills you need as a nurse. These skills are timeless in the fat that you will always need to use them at some level. Of course specific skills are good to have as well but these skills are universal and can help you in other areas of life as well.

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An animation illustrating valvular heart surgery

Masturbating is totally healthy, and totally normal. There are tons of myths out there meant to scare you into thinking masturbation is wrong or bad. But the truth is masturbation is perfectly safe. Masturbating won't make you blind, crazy, or stupid. It won’t damage your genitals, cause pimples, or stunt your growth. It doesn’t use up all your orgasms or ruin other kinds of sex. In fact, masturbation can actually be good for you. Here are some benefits of masturbation: Masturbation is safer than any other type of sex. You can’t get pregnant or get any sexually transmitted infections from masturbating. Masturbation can help you learn what you like and don’t like sexually. And if you decide to have sex with someone, you can know what you do/don’t want to do. BONUS: getting comfortable talking about sex and your body with your partner makes it easier to talk about protecting yourself against STDs and pregnancy, too. Exploring your body and learning how to give yourself sexual pleasure can be empowering and help improve your body image. Masturbation can lower stress and help you relax. It even helps some people fall asleep. Having an orgasm releases endorphins — feel good chemicals in your brain. Orgasms can be a natural painkiller and can even help with period cramps. Mutual masturbation (masturbating with a partner) is a really safe way to have sex and let the other person know what feels good to you. If you share a sex toy, use condoms on the toy and clean it before swapping. And if you touch each other’s genitals, wash your hands before touching your own. Can I get an STD from masturbating? Nope. Masturbating is the safest sexual activity out there. There is virtually NO chance of getting an STD or any other infection from touching your own genitals (and there’s also no chance of pregnancy). STDs have to be passed from one person to another, so you can’t give yourself an STD. The one exception to this is herpes - so if you have any cold sores on your mouth and touch them, make sure to wash your hands before masturbating. But it IS possible to get an STD if you’re masturbating with another person and touching each other’s genitals. Anytime semen (cum) or vaginal fluids are spread to someone else’s body, or your genitals rub against each other, there’s a risk of STDs. So if you touch each other’s genitals, wash your hands before touching your own. STDs can also be spread by sharing sex toys with another person. You can help protect yourself by using condoms on any toys that you share (even if they’re not shaped like a penis). Put a new condom on anytime a different person uses it. If you’re the only one using your sex toys, you don’t have to worry about STDs. But if you use them with other people, protect those sex toys just like you’d protect your own genitals — put a condom on ‘em! It’s possible for masturbation to cause irritation or infections if your body is sensitive to the way you masturbate or the things you masturbate with — but this isn’t the same thing as an STD. Lotions, Vaseline, oils, and scented or flavored stuff may irritate your vulva and vagina. Masturbating roughly and not using lubrication can also lead to irritation because of friction. And germs from the anus can cause vaginal infections — so never put something in your vagina that’s been in your butt without washing it or covering it with a condom. If you’re worried that you have an STD because of pain, itching, or discomfort in your genitals, go to your doctor or your local Planned Parenthood health center.

A tracheotomy or a tracheostomy is an opening surgically created through the neck into the trachea (windpipe) to allow direct access to the breathing tube and is commonly done in an operating room under general anesthesia. A tube is usually placed through this opening to provide an airway and to remove secretions from the lungs. Breathing is done through the tracheostomy tube rather than through the nose and mouth. The term “tracheotomy” refers to the incision into the trachea (windpipe) that forms a temporary or permanent opening, which is called a “tracheostomy,” however; the terms are sometimes used interchangeably.

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Watch Spinal Stenosis Videos Spinal stenosis occurs when the spinal cord in the neck (cervical spine) or the spinal nerve roots in the lower back (lumbar spine) are compressed. Symptoms of lumbar stenosis often include leg pain (sciatica) and leg tingling, weakness, or numbness. Arm pain is a typical symptom of cervical spinal stenosis. For cervical spinal stenosis with myelopathy, difficulty with coordination often occurs. Stenosis treatment may include non-surgical options (exercise, anti-inflammatory medication, epidural injections, and activity modification) or back surgery.

Patent ductus arteriosus (PDA) is a persistent opening between two major blood vessels leading from the heart. The opening, called the ductus arteriosus, is a normal part of a baby's circulatory system before birth that usually closes shortly after birth. If it remains open, however, it's called a patent ductus arteriosus. A small patent ductus arteriosus often doesn't cause problems and might never need treatment. However, a large patent ductus arteriosus left untreated can allow poorly oxygenated blood to flow in the wrong direction, weakening the heart muscle and causing heart failure and other complications. Treatment options for a patent ductus arteriosus include monitoring, medications and closure by cardiac catheterization or surgery.

Prostate biopsy is a procedure in which small hollow needle-core samples are removed from a man's prostate gland to be examined microscopically for the presence of cancer. It is typically performed when the result from a PSA blood test rises to a level that is associated with the possible presence of prostate cancer.

If you need heart bypass surgery, the procedure is pretty similar. A surgeon takes blood vessels from another part of your body to go around, or bypass, a blocked artery. The result is that more blood and oxygen can flow to your heart again. ... Bypass surgery is also known as coronary artery bypass grafting (CABG).Dec 12, 2015

Ever wonder what a drain is for after a Tummy Tuck? Here’s a short explanation by Dr. William.

#tummytuck #abdominoplasty #shorts

Biceps tenodesis surgery is performed when the biceps tendon is damaged, or the rotator cuff tendon or cartilage ring in the shoulder is torn. The biceps tendon is a strong rope‐like structure connecting the upper end of the biceps muscle to the bones in the shoulder. In biceps tenodesis surgery, the biceps tendon is separated from the shoulder and reattached to the humerus, or the upper arm bone.

Traditional African treatment for infertility

When the hematocrit rises to 60 or 70%, which it often does in polycythemia, the blood viscosity can become as great as 10 times that of water, and its flow through blood vessels is greatly retarded because of increased resistance to flow. This will lead to decreased oxygen delivery.

o you have an exercise routine that makes you feel absolutely awesome when you stick to it? Or a healthy eating pattern that makes you crackle with energy and vitality when you actually follow it. Well, today I’m sharing with you what makes me feel even more alive, energetic and vibrant than both of those… My daily sexual self-care practice.

Watch that video of a Knife Stabbed Inside Chest Removal Surgery

Polycystic liver disease (PLD or PCLD) is a rare condition that causes cysts -- fluid-filled sacs -- to grow throughout the liver. A normal liver has a smooth, uniform appearance. A polycystic liver can look like a cluster of very large grapes.

DOING LESS BUT BRAINY DESCRIBES A NEW GENERATION OF IMMEDIATE ZIRCONIA IMPLANTS ANATOMICAL AND CUSTOM-MADE. YOUR DENTAL ROOT IS MILLED IN ZIRCONIA AND IN 20 SECONDS SEATED, NO DRILLING, NO AUGMENTATION, NO MEMBRANES, FLAPLESS, NO 3D PLANNING, NO CAD/CAM SPLINTS OR GUIDED SURGERY REQUIRED! EASY AND CONSEQUENTIAL SYSTEM. NO MORE INCONGRUOUS AND UGLY SILVER-COLORED TITANIUM IMPLANTS IN TIME CONSUMING, PAINFUL AND COSTLY PROCEDURES. IT`S HIGH TIME TO RESPECT THE ANATOMY NOT ALTER IT BY DRILLING AND AUGMENTATION. BIOIMPLANT